A5033932830- Neuroscience and Neural Engineering
- Neurological disorders and treatments
- Neural dynamics and brain function
- Visual perception and processing mechanisms
- EEG and Brain-Computer Interfaces
- Vestibular and auditory disorders
- Tactile and Sensory Interactions
- Sleep and Wakefulness Research
- Advanced MRI Techniques and Applications
- Laser Applications in Dentistry and Medicine
- Neuroscience and Neuropharmacology Research
- Conducting polymers and applications
- Obsessive-Compulsive Spectrum Disorders
- Ocular Surface and Contact Lens
- Photoacoustic and Ultrasonic Imaging
- Advanced Memory and Neural Computing
- Neural and Behavioral Psychology Studies
- Optical Imaging and Spectroscopy Techniques
- Virus-based gene therapy research
- Advanced Neuroimaging Techniques and Applications
- Pluripotent Stem Cells Research
- Transgenic Plants and Applications
- Nerve injury and regeneration
- Migraine and Headache Studies
- Cancer Research and Treatments
Massachusetts General Hospital
2015-2022
Harvard University
2013-2022
Lemuel Shattuck Hospital
2017
University of Pittsburgh
2011-2013
Center for the Neural Basis of Cognition
2011-2013
Bioengineering Center
2011-2013
Objective: Our objective was to test the antidepressant effect of transcranial photobiomodulation (t-PBM) with near-infrared (NIR) light in subjects suffering from major depressive disorder (MDD). Background: t-PBM NIR is a new treatment for MDD. absorbed by mitochondria; it boosts cerebral metabolism, promotes neuroplasticity, and modulates endogenous opioids, while decreasing inflammation oxidative stress. Materials methods: We conducted double-blind, sham-controlled study on safety...
Purpose MRI may cause brain tissue around deep stimulation (DBS) electrodes to become excessively hot, causing lesions. The presence of extracranial loops in the DBS lead trajectory has been shown affect specific absorption rate (SAR) radiofrequency energy at electrode tip, but experimental studies have reported controversial results. goal this study was perform a systematic numerical provide better understanding effects leads on local SAR during 64 and 127 MHz. Methods A total 160...
Clinical electrical stimulation systems--such as pacemakers and deep brain stimulators (DBS)--are an increasingly common therapeutic option to treat a large range of medical conditions. Despite their remarkable success, one the significant limitations these devices is limited compatibility with magnetic resonance imaging (MRI), standard diagnostic tool in medicine. During MRI exam, leads used devices, implanted body patient, act electric antenna potentially causing amount energy be absorbed...
The transcranial photobiomodulation (t-PBM) technique is a promising approach for the treatment of wide range neuropsychiatric disorders, including disorders characterized by poor regulation emotion such as major depressive disorder (MDD). We examine various approaches to deliver red and near-infrared light dorsolateral prefrontal cortex (dlPFC) ventromedial (vmPFC) in human brain, both which have shown strong relevance MDD. apply our hardware-accelerated Monte Carlo simulations...
Neuromodulation is a promising treatment modality for disorders of learning and memory, offering the possibility precise alteration disordered neural circuits. Studies to date have failed identify an optimal target stimulation paradigm. Six epilepsy patients with depth electrodes implanted seizure localization participated in our study. We recorded local field potentials from while subjects associative task requiring them learn association between presented images button press. Three...
Microstimulation is widely used in neurophysiology to characterize brain areas with behavior and clinical therapeutics treat neurological disorder. Current intensity frequency, which respectively influence activation patterns spatial temporal domains, are typically selected elicit a desired response, but their effective on has not been thoroughly examined. We delivered microstimulation the primate superior colliculus while systematically varying each parameter capture effects of large range...
Whether allocation of visuospatial attention can be divorced from saccade preparation has been the subject intense research efforts. A variant visual search paradigm, in which a feature singleton indicates that correct should directed to it (prosaccade) or opposite distractor (antisaccade), influential addressing this core topic. We performed causal assessment controversy by delivering an air puff one eye invoke trigeminal blink reflex as monkeys task. Blinks effectively remove saccadic...
To help understand the order of events that occurs when generating saccades, we simulated and tested two commonly stated decoding models are believed to occur in oculomotor system: vector averaging (VA) center-of-mass. generate accurate each model incorporates required criteria: 1) a mechanism deciphers population response superior colliculus (SC) 2) an exponential transformation converts saccade into visual coordinates. The these criteria is used differently within model, yet significance...
Population coding is a ubiquitous principle in the nervous system for proper control of motor behavior. A significant amount research dedicated to studying population activity superior colliculus (SC) investigate saccadic eye movements. Vector summation with saturation (VSS) has been proposed as mechanism how SC can be decoded generate saccades. Interestingly, model produces different predictions when decoding two simultaneous populations at high vs. low levels activity. We tested these by...
Abstract The primate brain has the remarkable ability of mapping sensory stimuli into motor behaviors that can lead to positive outcomes. We have previously shown during reinforcement visual-motor behavior, activity in caudate nucleus is correlated with rate learning. Moreover, phasic microstimulation period was enhance associative learning, demonstrating importance temporal specificity manipulate learning related changes. Here we present evidence extends upon our previous finding by...
Purpose To develop an electrocorticography (ECoG) grid by using deposition of conductive nanoparticles in a polymer thick film on organic substrate (PTFOS) that induces minimal, if any, artifacts computed tomographic (CT) and magnetic resonance (MR) images is safe terms tissue reactivity MR heating. Materials Methods All procedures were approved the Animal Care Use Committee complied with Public Health Services Guide for Animals. Electrical functioning PTFOS cortical recording stimulation...
Traumatic brain injury (TBI) is a significant cause of morbidity and mortality worldwide. Despite improvements in survival, treatments that improve functional outcome remain lacking. There is, therefore, pressing need to develop novel recovery. Here, we investigated task-matched deep-brain stimulation the nucleus accumbens (NAc) augment reinforcement learning rodent model TBI. We demonstrate deep (DBS) NAc can enhance following further animals receiving DBS exhibited greater behavioral...
Current knowledge of saccade-blink interactions suggests that blinks have paradoxical effects on saccade generation. Blinks suppress generation by attenuating the oculomotor drive command in structures like superior colliculus (SC), but they also disinhibit saccadic system removing potent inhibition pontine omnipause neurons (OPNs). To better characterize these effects, we evoked trigeminal blink reflex delivering an air puff to one eye as saccades were sub-optimal stimulation SC. For every...
INTRODUCTION: Considerable evidence points to cortico-striato-thalamo-cortical circuits in cognitive, limbic, and motor functions. Specifically, the connections between caudate, nucleus accumbens (NAc), prefrontal cortex have been implicated behavioral learning motivation. Precisely timed stimulation of caudate during a task enhances beyond baseline normal primates. We test overarching hypothesis that combined intermittent NAc leads enhanced learning. Our specific is there are 2 streams...
Diseases and disorders of the central nervous system (CNS) represent a large field unmet need that significantly impacts lifespan quality life many patients. The ability to deliver therapeutic proteins from systemic circulation CNS is hampered by blood-brain barrier (BBB). A number strategies have been developed allow therapies cross BBB, but date with limited success. We novel localized approach protein peptide therapeutics based on our proprietary Transduced Autologous Restorative Gene...