A5074955194- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Bladder and Urothelial Cancer Treatments
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Lung Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- RNA modifications and cancer
- Radiomics and Machine Learning in Medical Imaging
- Cancer Mechanisms and Therapy
- Congenital Heart Disease Studies
- Lung Cancer Research Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- dental development and anomalies
- Autophagy in Disease and Therapy
- Oral and Maxillofacial Pathology
- Traumatic Ocular and Foreign Body Injuries
- Long-Term Effects of COVID-19
- Inflammation biomarkers and pathways
Clinica Universidad de Navarra
2017-2024
Universidad de Navarra
2003-2022
Navarre Institute of Health Research
2021-2022
Centro de Investigación Biomédica en Red de Cáncer
2018-2021
Hospital Virgen del Valle
1986
Abstract Neutrophil extracellular traps (NETs) are webs of nuclear DNA extruded by dying neutrophils infiltrating tissue. NETs constitute a defence mechanism to entrap and kill fungi bacteria. Tumours induce the formation advantage malignancy via variety mechanisms shown in mouse models. Here, we investigated presence human solid tumours their association with IL‐8 (CXCL8) protein expression CD8 + T‐cell density tumour microenvironment. Multiplex immunofluorescence panels were developed...
Rationale: The characterization of new genetic alterations is essential to assign effective personalized therapies in non-small cell lung cancer (NSCLC). Furthermore, finding stratification biomarkers for successful therapies. Molecular YES1, a member the SRC (proto-oncogene tyrosine-protein kinase Src) family kinases (SFKs), can be found significant subset patients with cancer.Objectives: To evaluate YES1 (v-YES-1 Yamaguchi sarcoma viral oncogene homolog 1) alteration as therapeutic target...
The use of immune-checkpoint inhibitors has drastically improved the management patients with non-small cell lung cancer (NSCLC), but innate and acquired resistances are hurdles needed to be solved. Immunomodulatory drugs that can reinvigorate immune cytotoxic activity, in combination antiprogrammed death 1 (PD-1) antibody, a great promise overcome resistance. We evaluated impact SRC family kinases (SFKs) on NSCLC prognosis, immunomodulatory effect SFK inhibitor dasatinib, anti-PD-1,...
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<div>Abstract<p>The precise mechanisms by which the complement system contributes to establishment of an immunosuppressive tumor microenvironment and promotes progression remain unclear. In this study, we investigated expression function C5a receptor 1 (C5aR1) in human mouse cancer-associated dendritic cells (DC). First, observed overexpression C5aR1 tumor-infiltrating DCs, compared with DCs from blood or spleen. was restricted type 2 conventional monocyte-derived displayed a...
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Two hundred forty-nine cases of Q fever were documented at the laboratories Centro Nacional de Microbiologia, Virologia e Inmunologia Sanitarias (CNMVIS) during 5-year period 1981–1985. thirty-four corresponded to acute infections, mostly sporadic but including two epidemics. The clinical presentation was respiratory in 74% and febrile 18%. Fifteen cases, all one which endocarditis, categorized as chronic. studied referred from almost every region Spain. epidemiologic analyses number...