A5040905146- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Advanced Radiotherapy Techniques
- Immunotherapy and Immune Responses
- Radiomics and Machine Learning in Medical Imaging
- Cancer Treatment and Pharmacology
- Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Medical Imaging and Pathology Studies
- Neuroendocrine Tumor Research Advances
- Venous Thromboembolism Diagnosis and Management
- Cancer-related molecular mechanisms research
- Diabetes Treatment and Management
- Bioinformatics and Genomic Networks
- Brain Metastases and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- interferon and immune responses
Clinica Universidad de Navarra
2014-2025
Pontificia Universidad Católica de Chile
2023
Universidad de Navarra
2005-2020
Navarre Institute of Health Research
2015-2020
Centro de Investigación Biomédica en Red de Cáncer
2018
Amsterdam UMC Location VUmc
2009
Clackamas Radiation Oncology Center
2009
European Society for Medical Oncology
2009
Universitätsmedizin Greifswald
2009
Central University Hospital of Asturias
2007
Nivolumab was assessed in patients with virus-associated tumors the phase I/II CheckMate 358 trial (ClinicalTrials.gov identifier: NCT02488759). We report on recurrent/metastatic cervical, vaginal, or vulvar cancers.
Interleukin-8 (IL8) is a chemokine produced by malignant cells of multiple cancer types. It exerts various functions in shaping protumoral vascularization and inflammation/immunity. We evaluated sequential levels serum IL8 preclinical tumor models patients to assess its ability estimate burden.IL8 were monitored sandwich ELISAs cultured supernatants, tumor-xenografted mice serum, samples from 126 with cancer. correlated baseline burden treatment-induced changes burden, as well prognosis.IL8...
Vascular endothelial growth factor (VEGF) inhibits differentiation and maturation of dendritic cells (DC), suggesting a potential immunosuppressive role for this proangiogenic factor. Bevacizumab, sorafenib sunitinib target VEGF-mediated angiogenesis are active against several types cancer, but their effects on the immune system poorly understood. In study, VEGF supernatants renal carcinoma cell lines cultured under hypoxia were found to alter human monocytes DC. Resulting DC showed impaired...
Activation of the ERK1/2 pathway is involved in malignant transformation both vitro and vivo. Little known about role activated non-small cell lung cancer (NSCLC). The purpose this study was to characterise extent activation by immunohistochemistry patients with NSCLC, determine relationship clinicopathological variables. Specimens from 111 NSCLC (stages I–IV) were stained for P-ERK. Staining epidermal growth factor receptor (EGFR) Ki-67 also performed. In all, 34% tumour specimens showed...
Abstract Background: NIVO (anti-PD-1) is approved for the treatment of several cancers including advanced melanoma, but its efficacy in other types skin cancer has not yet been evaluated. MCC a rare and aggressive form cancer, with most tumors being associated Merkel cell polyomavirus. MCCs frequently express PD-L1, MCC-reactive T cells PD-1. Methods: In CheckMate 358 (NCT02488759), patients (pts) 5 virus-associated who had received ≤2 prior therapies, an ECOG PS 0-1, were eligible to...
5504 Background: Treatment options for cervical, vaginal, and vulvar (GYN) cancers are limited after first-line therapy. Human papillomavirus (HPV) infection is associated with squamous cell carcinomas of the cervix (≥90%) vulva/vagina (40–70%), may elicit an immune reaction. Programmed death (PD)-1 its major ligand PD-L1 expressed in GYN inhibit responses. Nivolumab disrupts PD-1–mediated signaling, restoring antitumor immunity. Methods: In CheckMate 358 (NCT02488759), ongoing multicohort...
<i>Objective:</i> Paclitaxel-cisplatin is considered to be a standard therapy for metastatic non-small-cell lung cancer (NSCLC). The aim of this study was evaluate the activity and toxicity combination with vinorelbine or gemcitabine as front-line in brain metastases from NSCLC. <i>Methods:</i> Twenty-six chemotherapy-naive patients an ECOG performance status 0–2 were treated paclitaxel (135 mg/m<sup>2</sup>) on day 1, cisplatin (120 either (30 days 1 15...
Abstract Purpose: An increase in the activity of mitogen-activated protein kinases (MAPKs) has been correlated with a more malignant phenotype several tumor models vitro and vivo. A key regulatory mechanism MAPKs [extracellular signal-regulated kinase (ERK); c-jun NH2-terminal (JNK); p38] is dual specificity phosphatase CL100, also called MAPK phosphatase-1 (MKP-1). This study was designed to examine involvement CL100/MKP-1 stress-related lung cancer. Experimental Design: We assessed...
To identify tissue microRNAs predictive of sunitinib activity in patients with metastatic renal-cell-carcinoma (MRCC) and to evaluate vitro their mechanism action resistance.We screened 673 using TaqMan Low-density-Arrays (TLDAs) tumors from MRCC extreme phenotypes marked efficacy resistance sunitinib, selected an identification cohort (n = 41). The most relevant differentially expressed were bioinformatics-based target prediction analysis quantified by qRT-PCR presenting similar independent...
Cetuximab, an antibody targeting the epidermal growth factor receptor (EGFR), increases survival in patients with advanced EGFR-positive non-small cell lung cancer when administrated combination chemotherapy. In this study, we investigated role of complement activation antitumor mechanism therapeutic drug.EGFR-expressing lines were able to bind cetuximab and initiate by classical pathway, irrespective mutational status EGFR. This led deposition components increase complement-mediated death....
Full-dose postoperative external beam radiation therapy (EBRT)/chemoradiation is the standard of care in patients with resected, unirradiated head and neck cancer (HNC). This study aims to determine long-term results adjuvant high-dose rate (HDR) brachytherapy ± intermediate-dose this HNC patient population. From 2000 2018, a total 152 diagnosed were treated surgery HDR alone (n = 32) or combined EBRT chemotherapy 120). Patients received 32 40 Gy 8 10 b.i.d. fractions. Combined modality 16...
To compare the safety and efficacy of misoprostol oxytocin for induction labor. One hundred thirty women requiring labor were randomized to receive either intravenous or 100 μg misoprostol, administered intravaginally every 4 hours until was established. Compared with receiving oxytocin, a greater percentage in group had Bishop scores 3 less (58 versus 38%, P < .05). Nonetheless, median induction-to-delivery interval significantly shorter (585 885 minutes, .001) group. Women more likely...
Abstract: Pemphigus vulgaris (PV) is an autoimmune blistering disease characterized by the presence of IgG autoantibodies against Dsg3. Our aim was to investigate molecular events implicated in development and localization apoptosis acantholysis PV. We used a passive transfer mouse model together with immunohistochemical (IHC) techniques TUNEL assay, quantification analysis basal layer epidermis. The activated signalling molecules analysed apoptotic cells detected showed identical...
Mutation analysis of epidermal growth factor receptor (EGFR) gene is essential for treatment selection in non-small cell lung cancer (NSCLC). Analysis usually performed tumor samples. We evaluated the clinical utility EGFR plasma cell-free DNA (cfDNA) from patients under with inhibitors. selected 36 NSCLC and EGFR-activating mutations. Blood samples were collected at baseline during Wild-type EGFR, L858R, delE746-A750, T790M mutations quantified cfDNA by droplet digital PCR. Stage IV had...