A5100411801- Protein Interaction Studies and Fluorescence Analysis
- Receptor Mechanisms and Signaling
- Computational Drug Discovery Methods
- Drug Transport and Resistance Mechanisms
- Analytical Chemistry and Chromatography
- Molecular Sensors and Ion Detection
- Sulfur Compounds in Biology
- Bioactive Compounds and Antitumor Agents
- Biological Activity of Diterpenoids and Biflavonoids
- Chromatography in Natural Products
- Synthesis and biological activity
- Fungal Plant Pathogen Control
- Trace Elements in Health
- Alzheimer's disease research and treatments
- Synthesis and Reactions of Organic Compounds
- Analytical Chemistry and Sensors
- Biochemical and Molecular Research
- Phenothiazines and Benzothiazines Synthesis and Activities
- Chemical Synthesis and Analysis
- Selenium in Biological Systems
- Acupuncture Treatment Research Studies
- Protein purification and stability
- Quinazolinone synthesis and applications
- Antioxidant Activity and Oxidative Stress
- Biopolymer Synthesis and Applications
Liaoning University
2010-2022
Educational Department of Liaoning Province
2019-2022
First Hospital of China Medical University
2017
China Medical University
2017
University of California, San Francisco
2012-2014
Chongqing University
2013
Ernest Gallo Clinic and Research Center
2012
Excessive accumulation of amyloid-β (Aβ) is the leading cause Alzheimer's disease (AD). Liensinine, Isoliensinine, and Neferine are main alkaloids in lotus seed embryos. In this paper, protective effects on Aβ25–35-injured PC12 cells were studied. It was found that could improve viability reduce apoptosis cell induced by Aβ25–35. These three also level intracellular free Ca2+ CaM expression Aβ25–35-treated cells, thereby inhibiting phosphorylation CaMKII tau. addition, these compounds can...
To better study the role of PKCδ in normal function and disease, we developed an ATP analog-specific (AS) that is sensitive to specific kinase inhibitors can be used identify substrates. AS showed nearly 200 times higher affinity (Km) 150 efficiency (kcat/Km) than wild type (WT) toward N6-(benzyl)-ATP. was uniquely inhibited by 1-(tert-butyl)-3-(1-naphthyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (1NA-PP1) 1-(tert-butyl)-3-(2-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (2MB-PP1) but not...
The title compound, 5-(4-fluorophenyl)-N,N-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, has been synthesised by condensation of dimethylamine with 5-(4-fluorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid. This intermediate was prepared from ethyl 5-amino-1H-pyrazole-4-carboxylate cyclisation 4,4,4-trifluoro-1-(4-fluorophenyl)butane-1,3-dione and then saponification sodium hydroxide. crystal structure the compound determined. possesses distinct...
To observe the effect of electroacupuncture (EA) at "Zusanli" (ST 36) on duodenal mast cells, nerve growth factor (NGF) and neurotrophic tyrosine kinase receptor type 1 (NTRK1), to explore mechanism Zusanli functional dyspepsia (FD).Sixty SPF-grade 10-day-old SD rats were randomly divided into a normal group, model ketotifen group an EA 15 in each group. The FD was prepared by iodoacetamide combined with rat tail clamping method injected intraperitoneally (1 mg•kg-1•d-1) for 7 days; treated...
A series of novel substituted 5-amino-8 H-phthalazino[1,2- b]quinazolin-8-one derivatives synthesised by condensation different amines with 5-chloro-8 b]quinazolin-8-one, which was prepared from methyl 2-aminobenzoate hydrazine hydrate and then cyclisation a phthalic anhydride in N,N-dimethylacetamide at refluxing condition. The intermediate target compounds were obtained good yields easily purified filtration or recrystallisation.
Abstract A novel method for the determination of trace amounts lead(II), based on resonance Rayleigh scattering (RRS) technique, has been developed. In neutral solution, in presence TX‐100, lead(II) can react with 1‐(2‐pyridylazo)‐2‐naphthol (PAN) to form a chelating complex, resulting significant enhancement RRS intensity. The characteristics spectrum influencing factors, and optimum conditions reaction have investigated. calibration graph showed good linearity over concentration range...
L-Aromatic amino acid is a kind of essential substance body metabolism.It widely applied in pharmaceutical, food and daily chemical industry.Although, the L-aromatic could be obtained by synthesis, its separation from fermentation liquid more important.At present, common method for Laromatic ion exchange 1,2 or liquid-liquid extraction [3][4][5] .Ion based on ionic bond.Liquid-liquid electrostatic bond hydrogen coordination generated between extractant solute.Nevertheless, only part...