A5030555096- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Alzheimer's disease research and treatments
- Mast cells and histamine
- Adenosine and Purinergic Signaling
- Bipolar Disorder and Treatment
- Histone Deacetylase Inhibitors Research
- Nicotinic Acetylcholine Receptors Study
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Memory and Neural Mechanisms
- Neuroscience of respiration and sleep
- Cholinesterase and Neurodegenerative Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Nuclear Receptors and Signaling
- Estrogen and related hormone effects
- Muscle metabolism and nutrition
- Genetics and Neurodevelopmental Disorders
- Apelin-related biomedical research
- Tryptophan and brain disorders
- Exercise and Physiological Responses
- Hypothalamic control of reproductive hormones
- Social Media in Health Education
- Healthcare Operations and Scheduling Optimization
- Medicinal Plants and Neuroprotection
- Laser Applications in Dentistry and Medicine
Universidade de São Paulo
2022-2024
Universidade de Mogi das Cruzes
2024
Faculdade de Ciências Médicas da Santa Casa de São Paulo
2011-2021
Czech Academy of Sciences, Institute of Physiology
2003
Université de Montréal
2002
Universidade Federal de São Paulo
1997-2001
Systemic bacterial infections often result in enduring cognitive impairment and are a risk factor for dementia. There currently no effective treatments infection-induced impairment. Previous studies have shown that intermittent fasting (IF) can increase the resistance of neurons to injury disease by stimulating adaptive cellular stress responses. However, impact IF on sequelae systemic brain inflammation is unknown.Rats 30 days received 1 mg/kg lipopolysaccharide (LPS) or saline...
A lower incidence of dementia in bipolar patients treated with lithium has been described. This metal inhibits the phosphorylation glycogen-synthase-kinase 3-α and β, which are related to amyloid precursor protein processing tau hyperphosphorylation pathological conditions, respectively. Following same rationale, a group just found that disease-modifying properties amnestic mild cognitive impairment potential clinical implications for prevention Alzheimer's Disease (AD) when dose ranging...
The use of lithium is well established in bipolar disorders and the benefits are being demonstrated neurodegenerative disorders. Recently, our group showed that treatment with microdose stabilized cognitive deficits observed Alzheimer’s disease (AD) patients. In order to verify potential preventing development, aim this work was effects chronic given before after appearance symptoms a mouse model similar AD. Transgenic mice (Cg-Tg(PDGFB-APPSwInd)20Lms/2J) their non-transgenic litter mate...
Alzheimer's disease is a chronic and degenerative condition that had no treatment until recently. The current therapeutic strategies reduce progression of the but are expensive commonly cause side effects uncomfortable for treated patients. Functional foods to prevent and/or treat many conditions, including neurodegenerative diseases, represent promising field study currently gaining attention. To this end, here we demonstrate pomegranate (Punica granatum) peel extract (PPE) regarding...
Renal insufficiency can have a negative impact on cognitive function. Neuroinflammation and changes in klotho levels associate with chronic kidney disease (CKD) may play role the development of impairment (CI). The present study evaluates correlation deficits neuroinflammation soluble KLOTHO cerebral spinal fluid (CSF) brain tissue nephrectomized rats (Nx), 5/6 renal mass ablation. Nx sham Munich Wistar were tested over 4 months for locomotor activity, as well inhibitory avoidance or novel...
Alzheimer's disease (AD) is associated with a progressive dementia, and there good evidence that it more pronounced in individuals have fewer stimuli during their lives. Environmental stimulation promotes morphological functional changes the brain, leading to amplification of cognitive functions, has been described humans animals. In this study, we evaluated effects enriched environment (EE) on spatial memory senile plaque formation transgenic mice PDGFB-APPSwInd (TG) overexpress human...
Cell senescence is a process that causes growth arrest and the release of associated secretory phenotype (SASP), characterized by secretion chemokines, cytokines, cell factors metalloproteases, leading to tissue condition may precipitate cancers neurodegenerative processes. With recent pandemic coronavirus, senolytic drugs are being considered as possible therapeutic tools reduce virulence SARS-CoV-2. In last few years, our research group showed lithium carbonate at microdose levels was able...
The participation of the paratrigeminal nucleus (Pa5) in pressor response produced by bradykinin dorsolateral medulla rats was investigated. microinjection 6 pmol directly over unanaesthetized a significant increase arterial pressure and moderate heart rate. Bradykinin microinjections different sites surrounding Pa5 compromising external cuneate nucleus, trigeminal lateral ventral spinal tract dorsal rostral caudal to did not elicit responses. In contrast, effects. Injections larger...
The effects of intrathecally (i.t.) injected kinin B 1 and 2 receptor agonists antagonists were measured on mean arterial pressure (MAP) heart rate (HR) conscious unrestrained spontaneously hypertensive rats (SHR 16 weeks old) age‐matched normotensive Wistar Kyoto (WKY). Quantitative in vitro autoradiographic studies also performed the thoracic spinal cord both strains with specific radioligands for receptors, [ 125 I]‐HPP‐Hoe 140, I]‐HPP‐[des‐Arg 10 ]‐Hoe140. Bradykinin (BK) (0.81 – 810...
Kinins have been elected to the status of central neuromediators. Their effects are mediated through activation two G-protein-coupled receptors, denoted B 1 and 2 . Functional binding studies suggested that receptors upregulated in medulla spinal cord hypertensive diabetic rats. The aim this study was localize quantify kinin post-mortem human obtained from normotensive, hypertensive, subjects, using vitro receptor autoradiography with radioligands [ 125 I]HPP-HOE140 (B receptor)...
Abstract A role for kinin B 1 receptors was suggested in the spinal cord and peripheral organs of streptozotocin (STZ)‐diabetic rats. The present study aims at determining whether are also induced over‐expressed brain STZ‐rats 2, 7, 21 days post‐treatment. This addressed by situ hybridization using [ 35 S]‐UTPαS‐labeled riboprobe vitro autoradiography with radioligand 125 I]‐HPP‐des‐Arg 10 ‐Hoe 140. In control rats, receptor mRNA found widely distributed many regions. Low levels were...
With the use of in vitro receptor autoradiography, this study aims at determining whether higher level kinin B 2 density spinal cord spontaneously hypertensive rat (SHR) is secondary to arterial hypertension and chronic treatment with angiotensin I-converting enzyme inhibitors (ACEI) can regulate neuronal 1 receptors. SHR received, from age 4 wk, one two ACEI (lisinopril or zofenopril, 10 mg · kg −1 day ) for comparison, selective AT antagonist (losartan, 20 their drinking water a period 4,...
Background and Purpose Attention training reverses the neurodegeneration memory loss promoted by infusion of amyloid‐β (Aβ) peptide in rats increases density α7 nicotinic ACh receptors (α7nAChRs) brain areas related to memory. Hence, we aimed assess role α7nAChRs recovery attention training. Experimental Approach C57Bl/6 mice were chronically infused with Aβ, Aβ plus antagonist methyllycaconitine (MLA), or MLA alone. Control animals vehicle. Animals subjected weekly active avoidance shuttle...