Bernadette Leggett

ORCID: 0000-0002-1883-8800
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About
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Research Areas
  • Bacterial Identification and Susceptibility Testing
  • Antimicrobial Resistance in Staphylococcus
  • Streptococcal Infections and Treatments
  • Diphtheria, Corynebacterium, and Tetanus
  • Microbial infections and disease research
  • Bacterial biofilms and quorum sensing
  • Clostridium difficile and Clostridium perfringens research
  • Biochemical and Structural Characterization
  • Tendon Structure and Treatment
  • Osteoarthritis Treatment and Mechanisms
  • Infection Control in Healthcare
  • Veterinary medicine and infectious diseases
  • Infectious Diseases and Mycology
  • Infective Endocarditis Diagnosis and Management
  • Antibiotic Resistance in Bacteria
  • Veterinary Equine Medical Research
  • Veterinary Oncology Research
  • Food Safety and Hygiene

University College Dublin
2010-2023

Abstract Objectives MDR methicillin-resistant Staphylococcus pseudintermedius (MRSP) strains have emerged rapidly as major canine pathogens and present serious treatment issues concerns to public health due their, albeit low, zoonotic potential. A further understanding of the genetics resistance arising from a broadly susceptible background S. is needed. Methods We sequenced genomes 12 isolates varied STs phenotypes. Results Nine distinct clonal lineages had acquired either staphylococcal...

10.1093/jac/dku496 article EN Journal of Antimicrobial Chemotherapy 2014-12-18

This study compares the characteristics of Staphylococcus epidermidis (SE) and haemolyticus (SH) isolates from epidemiologically unrelated infections in humans (Hu) (28 SE-Hu; 8 SH-Hu) companion animals (CpA) (12 SE-CpA; 13 SH-CpA). All underwent antimicrobial susceptibility testing, multilocus sequence typing DNA microarray profiling to detect resistance SCCmec-associated genes. methicillin-resistant (MR) (33/40 SE, 20/21 SH) dru mecA allele typing. Isolates were predominantly assigned...

10.1371/journal.pone.0138079 article EN cc-by PLoS ONE 2015-09-17

The equine disease strangles, which is characterized by the formation of abscesses in lymph nodes head and neck, one most frequently diagnosed infectious diseases horses around world. causal agent, Streptococcus equi subspecies equi, establishes a persistent infection approximately 10 % animals that recover from acute disease. Such 'carrier' appear healthy are rarely identified during routine veterinary examinations pre-purchase or transit, but can transmit S. to naïve initiating new...

10.1099/mgen.0.000528 article EN cc-by Microbial Genomics 2021-03-01

A retrospective analysis and prospective surveillance study were conducted to determine isolation rates of meticillin-resistant Staphylococcus aureus (MRSA) in dogs, cats horses Ireland. Clinical samples that had been submitted University College Dublin (UCD) for routine microbiological examination over a four-year period (2003 2006) analysed the analysis, which included clinical from 3866 animals. In study, healthy animals presenting elective surgery as well with presentation suggestive...

10.1136/vr.b4814 article EN Veterinary Record 2010-04-01

The main purpose of this study was to investigate the cleanliness and microbial burden a veterinary hospital establish extent cross-contamination with faecal bacteria as an aid reducing nosocomial infections. Enterococci Escherichia coli were used indicator organisms they can survive on inanimate surfaces for months pose threat animal health. consisted several elements: (i) cross-sectional identify sites currently contaminated that could be usefully included in longitudinal study, (ii)...

10.1186/s13620-023-00229-w article EN cc-by Irish Veterinary Journal 2023-02-13

Objectives To describe infection in companion animals with the zoonotic pathogen Corynebacterium ulcerans and to determine its prevalence clinically‐affected healthy animals. Materials Methods The clinical presentation treatment of three cases C. is described. Two studies rates were undertaken: (a) a prospective study nasal samples from animals, 479 dogs 72 cats; (b) retrospective analysis records collected over 10‐year period 189 64 cats affected by respiratory signs. Results Toxigenic was...

10.1111/jsap.13185 article EN Journal of Small Animal Practice 2020-07-30

A three year old male entire Staffordshire bull terrier was referred to University College Dublin Veterinary Hospital, with a two week history of fever, inflammation the right hock, lameness on hindlimb, peripheral lymphadenopathy and gastrointestinal signs (vomiting diarrhoea). For preceding months dog had been treated for atopic dermatitis oral ciclosporin (5 mg/kg, PO, q 24 hours). Cytological analysis affected lymph nodes demonstrated fungal-like organisms predominantly contained within...

10.1186/2046-0481-67-17 article EN cc-by Irish Veterinary Journal 2014-08-06

The present study highlights challenges in the veterinary microbiology diagnostic laboratory identification of bacteria responsible for infections settings, particularly when evidence-based data is lacking. A 1.8-year-old neutered male domestic cat (FIV/FeLV negative) was presented to a practice April 2016 with history left unilateral mild conjunctivitis that empirically treated fusidic acid and chloramphenicol. In January 2017, same animal chronic an eye swab submitted microbiological...

10.1099/acmi.0.000118 article EN cc-by-nc Access Microbiology 2020-03-20
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