A5022579235- Cold Atom Physics and Bose-Einstein Condensates
- Heat shock proteins research
- Physics of Superconductivity and Magnetism
- Immune Cell Function and Interaction
- Asthma and respiratory diseases
- Immunotherapy and Immune Responses
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Strong Light-Matter Interactions
- DNA Repair Mechanisms
- Quantum, superfluid, helium dynamics
- Genetic factors in colorectal cancer
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Viral gastroenteritis research and epidemiology
- Allergic Rhinitis and Sensitization
- Genomics and Chromatin Dynamics
- Cancer-related gene regulation
- Molecular Biology Techniques and Applications
- Quantum many-body systems
- Viral Infections and Immunology Research
- Digestive system and related health
- Wnt/β-catenin signaling in development and cancer
- Dermatology and Skin Diseases
Catharina Ziekenhuis
2025
Radboud University Nijmegen
2025
The Netherlands Cancer Institute
1996-2020
Oncode Institute
1991-2020
Delta Institute for Theoretical Physics
2009-2011
University of Amsterdam
1990-2011
Academic Medical Center
1997-2011
Goethe University Frankfurt
2008-2009
Utrecht University
1977-2004
MRC Epidemiology Unit
1993
Lymphokine secretion profiles were studied of human allergen-specific CD4+ T lymphocyte clones (TLC). To this aim, panels house dust mite Dermatophagoides pteronyssinus (Dp)-specific TLC generated from two atopic Dp-allergic patients, suffering severe dermatitis (AD1) and allergic asthma (AD2), respectively, a non-atopic individual (NAD). From AD1 additional cloned specific for tetanus toxoid or Candida albicans, both Ag that not relevant the state patient. Secretion IL-2, IL-4, IFN-gamma...
Abstract Eight representative T lymphocyte clones (TLC) randomly selected from previously described panels of CD4+ housedust mite Dermatophagoides pteronyssinus (Dp)-specific TLC atopic and nonatopic donors were studied in more detail a comparative investigation. The the closely resembled murine type 2 Th (Th2) cells by secreting substantial IL-4, IL-5, IL-6, TNF-alpha, granulocyte-macrophage (GM)-CSF, minimal IFN-gamma, relatively little IL-2. In contrast, nonatopic's 1 (TH1) IL-2, GM-CSF,...
We apply dynamical mean-field theory to strongly interacting fermions in an inhomogeneous environment. With the help of this real-space (R-DMFT) we investigate antiferromagnetic states repulsively with spin- a harmonic potential. Within R-DMFT, order is found be stable spatial regions total particle density close one, but persists also parts system where local significantly deviates from half filling. In systems spin imbalance, find that antiferromagnetism gradually suppressed and phase...
We investigate spin-order of ultracold bosons in an optical lattice by means dynamical mean-field theory. A rich phase diagram with anisotropic magnetic order is found, both for the ground state and at finite temperatures. Within Mott insulator, a ferromagnetic to antiferromagnetic transition can be tuned using spin-dependent lattice. In addition we find supersolid phase, which superfluidity coexists spin order. present detailed diagrams temperature experimentally realized heteronuclear...
We study a mixture of strongly interacting bosons and spinless fermions with on-site repulsion in three-dimensional optical lattice. For this purpose we develop apply generalized dynamical mean-field theory, which is exact infinite dimensions reliably describes the full range from weak to strong coupling. restrict ourselves half filling. Bose-Fermi supersolid forms, bosonic superfluidity coexists charge-density wave order. stronger interspecies become localized while order persists. The...
Homologous recombination (HR) is a DNA repair process that requires homologous sequence for the of double-stranded breaks. The search homology rate limiting step HR, but dynamics in vivo are currently poorly understood. This largely due to lack tools visualize action living human cells. Here, we show RAD51 and MND1, two proteins operating search, become visible long filamentous structures several hours after break formation. Using GFP-MND1 can these filaments cells find they highly dynamic,...
The predisposition to colon cancer is multigenetically controlled in animals and probably also humans. We have analyzed the multigenic control of susceptibility 1,2-dimethylhydrazine-induced tumors mice by using a set 20 homozygous CcS/Dem recombinant congenic strains, each which contains different random subset approximately 12.5% genes from susceptible strain STS/A 87.5% relatively resistant BALB/cHeA. Some strains received alleles at one or more multiple tumor loci are susceptible,...
We study the magnetic ordering transition for a system of harmonically trapped ultracold fermions with repulsive interactions in cubic optical lattice, within real-space extension dynamical mean-field theory. Using quantum Monte Carlo impurity solver, we establish that antiferromagnetic correlations are signaled, at strong coupling, by an enhanced double occupancy. This signature is directly accessible experimentally and should be observable well above critical temperature long-range order....
Expression of CD44, particularly certain splice variants, has been linked to tumor progression and metastasis formation in a number different animal human cancers. Because cutaneous melanoma is among the most aggressive cancers, we explored expression CD44 isoforms (CD44v) lesions melanocytic progression. In addition, by RT-PCR FACS analysis assessed CD44v RNA species cell surface cultured melanocytes isolated from foreskin panel 2 non-, sporadically highly metastatic lines. We observed that...
The Neu1 locus, in the S region of murine histocompatibility-2 complex, regulates sialic acid content several liver lysosomal enzymes. Three alleles, Neu1a, Neu1b, and Neu1c, have been described on basis differential sialylation enzyme phosphatase. Neu1a allele occurs a small number mouse strains, e.g., SM/J is associated with sialidase deficiency. We recently G9, gene human major histocompatibility complex (Milner et al. (1997) J. Biol. Chem., 272, 4549-4558), we now report characterization...
Each allele at the K or D region of H-2 complex produces two kinds "allelic" mutually exclusive antigenic characteristics: its unique private specificity and a public specificity(ies) either H-2.28 H-2.1 family. The specificities regions are expressed on H-2K H-2D molecules, respectively. another molecule, H-2L, which lacks but exhibits specificity. We analyzed expression determinants H-2K, H-2D, H-2L molecules. When an antiserum against is used to sensitize cells where it can react with...
We give a detailed discussion of the recently developed generalized dynamical mean-field theory (GDMFT) for mixture bosonic and fermionic particles. show that this method is nonperturbative exact in infinite dimensions, reliably describes full range from weak to strong coupling. Like conventional theory, small parameter $1/z$, where $z$ lattice coordination number. apply GDMFT scheme spinless fermions bosons an optical lattice. investigate possibility supersolid phase, focusing on case 1/2...
The H–2L molecules were detected for the first time in D d region products using antisera against public specificity H‐2.28. This was analyzed because its presence K as well and apparent allelism with another specificity, H‐2.1, indicated that these two specificities may have a special position H‐2 system. corroborated by subsequent identification of H‐2L q k anti‐H‐2.28 anti‐H‐2.1 sera, respectively, while none other previously known or private on molecules. We tested four alleles which had...
Abstract Cdkn2ab knockout mice, generated from 129P2 ES cells develop skin carcinomas. Here we show that the incidence of these carcinomas drops gradually in course backcrossing to FVB/N background. Microsatellite analyses indicate this cancer phenotype is linked a 20 Mb region chromosome 15 harboring Wnt7b gene, which preferentially expressed allele and derived cell lines. ChIPseq analysis shows enrichment H3K27-Ac, mark for active enhancers, 5’ gene. The appears sufficient cause vitro...