Most information on bone-joint (BJ)-tuberculosis is based data from high-incidence areas. We conducted a nationwide register-based analysis of BJ-tuberculosis in Denmark 1994 to 2011.We linked the national tuberculosis surveillance system BJ-tuberculosis, hospital records, Danish Hospital and Civil Registration System.We identified 282 patients with 3.6% all cases (n = 7936). Spinal was found 153 (54.3%); 83.3% were immigrants. Danes older had higher Charlson comorbidity index scores than...

Tuberculous lymphadenitis (TBLA) is the most common extrapulmonary manifestation of tuberculosis (TB) in Denmark. However, clinical features patients with TBLA have never been systematically studied this setting.Patients treated for Central Region Denmark from 2007 to 2016 were identified using national TB surveillance register and The Danish Hospital Patient Registry. Data characteristics treatment extracted hospital records.Eighty-three identified. median age was 32 years (IQR 23-42); 71...

Recent surges in pertussis spread have renewed focus on vaccination strategies. Denmark implemented during pregnancy 2019 to protect infants under three months. This nationwide study assessed the real-world safety and effectiveness of acellular pregnancy. Using Danish registers, we included all pregnancies beyond 24 gestational weeks liveborn children from November 1, 2019, June 2023, with follow-up until December 31, 2023. Maternal outcomes hypertension, preeclampsia, chorioamnionitis,...

Abstract Monitoring of tuberculosis (TB) treatment outcome is essential to ensure an effective TB control program. In this nationwide retrospective cohort study from Denmark we present rates and risk factors associated with unfavourable outcome. All patients notified pulmonary 2009 through 2014 were included. Logistic regression analyses used identify for total, 1681 cases success increased during the period. 2014, rate reached 85% new culture positive whereas 7% interrupted treatment. The...

Abstract Background The global vision is a world free of tuberculosis (TB). Even in resource-rich TB low-incidence settings, we need more focus on the role social risk factors to end epidemic. Methods Nationwide, retrospective register-based, case–control study from 1990 2018, including all patients Denmark ≥18 years old (n = 9581) matched 1:3 sex and age with population controls. were assessed logistic regression models estimated by odds ratio (OR). Results All had considerably lower...

Abstract Background Extrapulmonary tuberculosis (EPTB) represents an increasing percentage of (TB) cases in Europe. However, strategies on TB prevention and successful treatment outcomes primarily target pulmonary TB. In this nationwide study, we present characteristics EPTB, outcomes, predictors for unfavorable outcomes. Methods All patients diagnosed with EPTB from 2009 to 2014 were included. Logistic regression analyses used identify risk factors outcome. The following definitions used:...

ObjectivesThis study aimed to analyze mortality, risk factors, and causes of death among people with tuberculosis (TB).MethodsThis is a population-based cohort patients TB ≥18 years notified from 1990 2018 in Denmark, compared sex- age-matched controls. Mortality was assessed Kaplan–Meier models factors for were estimated Cox proportional hazards models.ResultsOverall mortality twofold higher controls up 15 after diagnosis (hazard ratio [HR]: 2.18, 95% confidence interval [CI]: 2.06-2.29, P...

BackgroundMigrants account for the majority of tuberculosis (TB) cases in low-incidence countries western Europe. TB incidence among migrants might be influenced by patterns migration, but this is not well understood.AimTo investigate differences risk across migrant groups according to status and region origin.MethodsThis prospective cohort study included ≥ 18 years age who obtained residency Denmark between 1 January 1993 31 December 2015, matched 1:6 Danish-born individuals. Migrants were...

Background Tuberculous lymphadenitis (TBLA) is the most common extrapulmonary manifestation of tuberculosis (TB), often claimed to be reactivation. We aimed describe epidemiology TBLA in Denmark, as it has not previously been investigated specifically although TB associated with an increased long-term mortality and delays diagnosis. Methods Register-based study all patients notified Denmark from 2007 through 2016 utilizing six different nationwide registers. Patients were identified national...

Background Denmark possesses an exceptional historical data collection on tuberculosis (TB) from 1876 to the present, providing a unique opportunity assess TB epidemiology over 147 years in Denmark. Aim Our aim was describe disease burden relation events, living conditions and health interventions during past years. Methods We performed nationwide register-based ecological study including all persons with through 2022, correlating incidence social, economic indicators. Results In Denmark,...

Tuberculosis (TB) is a well-known occupational hazard. Based on more than two decades (1992–2012) of centralized nationwide genotyping all Mycobacterium tuberculosis culture-positive TB patients in Denmark, we compared M. genotypes from cases notified as presumed (N = 130) with present the country 7,127). From 1992 through 2006, IS6110 Restriction Fragment Length Polymorphism (RFLP) method was used for genotyping, whereas 2005 to present, 24-locus-based Mycobacterial Interspersed Repetitive...

Objectives Mortality from tuberculosis (TB) has been declining since 2000, nevertheless there is still a significant number of patients who die before or during TB treatment. The aims were to examine and describe predictors associated with related mortality. Methods Patients notified 2009 though 2014 in Denmark included. Data extracted national registers patient records examined for clinical information treatment outcome. Cox proportional hazards regression was used Results A total 2131...

For centuries, tuberculosis has been identified as a burden to seafarers. In this study, we assessed the magnitude of among merchant seafarers today. Furthermore, most likely routes M. transmission by use DNA fingerprinting. A database containing all culture-positive cases in Denmark 1992–2003 was combined with register on and their employment periods aboard Danish ships. All strains were analysed using DNA-subtyping. 64 culture positive identified. The risk males 1.51 (1.10–2.01) compared...

The objective of tuberculosis (TB) screening in low-incidence countries is to identify TB patients earlier, ideally improve health outcomes and reduce Mycobacterium transmission. In this retrospective study, we compare hospitalisation (morbidity) smear positivity rates (infectiousness) identified through active case finding (ACF) with passive (PCF).ACF were by socially marginalised persons or contact investigation. Logistic regression was used model the associations between case-finding...

In Western Europe, most pediatric tuberculosis (TB) cases occur among immigrants; however, data are rarely stratified by first/second-generation immigrants and many may be preventable.This was a nationwide study of children <18 years with TB from 2009 to 2014 in Denmark. Demographic, clinical, microbiologic treatment outcome were obtained registers medical records.We identified 145 cases; 99 (68%) which 54 (55%) second-generation immigrants. Most first-generation (73%) diagnosed passive case...

To describe demographics of tuberculosis (TB) in the Øresund region, southern Scandinavia, a retrospective analysis epidemiological data from TB registers and population databases, 1995 to 2002, was performed. A total 2678 cases were reported with an overall incidence 6.3 per 100,000 person-y observation. There major differences notification rates among immigrants depending on their country origin residence region. In Danish part, 37% all came Horn Africa compared 28% Swedish areas. Older...