A5057649419- Neural dynamics and brain function
- Advanced Memory and Neural Computing
- EEG and Brain-Computer Interfaces
- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Visual perception and processing mechanisms
- Neuroscience and Neural Engineering
- Receptor Mechanisms and Signaling
- Memory and Neural Mechanisms
- Mental Health Research Topics
- Neuroscience and Neuropharmacology Research
- Aortic Disease and Treatment Approaches
- Transcranial Magnetic Stimulation Studies
- Neurobiology and Insect Physiology Research
- Lysosomal Storage Disorders Research
- stochastic dynamics and bifurcation
- Autoimmune Neurological Disorders and Treatments
- Machine Learning in Materials Science
- Neuroscience and Music Perception
- Ferroelectric and Negative Capacitance Devices
- Cell Image Analysis Techniques
- Photoreceptor and optogenetics research
- Cancer Diagnosis and Treatment
- Hypertrophic osteoarthropathy and related conditions
- Color perception and design
École Normale Supérieure
2025
Université Paris-Saclay
2025
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2015-2024
École Normale Supérieure - PSL
2021-2024
Laboratoire de Neurosciences Cognitives
2021-2024
Inserm
2021-2024
Université Paris Sciences et Lettres
2021-2024
Adolfo Ibáñez University
2024
The amount of information that can be retained in working memory (WM) is limited. Limitations WM capacity have been the subject intense research, especially trying to specify algorithmic models for WM. Comparatively, neural circuit perspectives barely used test limitations behavioral experiments. Here we a neuronal microcircuit model visuo-spatial (vsWM) investigate several items. assumes there topographic organization responsible spatial retention. This assumption leads specific...
Abstract A mechanistic understanding of core cognitive processes, such as working memory, is crucial to addressing psychiatric symptoms in brain disorders. We propose a combined psychophysical and biophysical account two symptomatologically related diseases, both linked hypofunctional NMDARs: schizophrenia autoimmune anti-NMDAR encephalitis. first quantified shared memory alterations delayed-response task. In patient groups, we report markedly reduced influence previous stimuli on contents,...
Abstract Serial dependence, how immediately preceding experiences bias our current estimations, has been described experimentally during delayed-estimation of many different visual features, with subjects tending to make estimates biased towards previous ones. It proposed that these attractive biases help perception stabilization in the face correlated natural scene statistics, although this remains mostly theoretical. Color, which is strongly scenes, never studied regard its serial...
Persistently active neurons during mnemonic periods have been regarded as the mechanism underlying working memory maintenance. Alternatively, neuronal networks could instead store memories in fast synaptic changes, thus avoiding biological cost of maintaining an code through persistent firing. Such "activity-silent" codes proposed for specific conditions which are maintained a nonprioritized state, unattended but still relevant short-term memories. A hallmark this is that these can be...
Abstract Brains can gracefully weed out irrelevant stimuli to guide behavior. This feat is believed rely on a progressive selection of task-relevant across the cortical hierarchy, but specific across-area interactions enabling stimulus are still unclear. Here, we propose that population gating, occurring within primary auditory cortex (A1) controlled by top-down inputs from prelimbic region medial prefrontal (mPFC), support selection. Examining single-unit activity recorded while rats...
Abstract Coping with dementia requires an integrated approach encompassing personal, health, research, and community domains. Here we describe “Walking the Talk for Dementia,” immersive initiative aimed at empowering people dementia, enhancing understanding, inspiring collaborations. This involved 300 participants from 25 nationalities, including care partners, clinicians, policymakers, researchers, advocates a 4‐day, 40 km walk through Camino de Santiago Compostela, Spain. A 2‐day symposium...
Quantifying differences across species and individuals is fundamental to many fields of biology. However, it remains challenging draw detailed functional comparisons between large populations interacting neurons. Here, we introduce a general framework for comparing neural population activity in terms shape distances. This approach defines similarity explicit geometric transformations, which can be flexibly specified obtain different measures population-level similarity. Moreover, systems are...
How the prefrontal hemispheres coordinate to adapt spatial working memory (WM) demands remains an open question. Recently, two models have been proposed: A specialized model, where each hemisphere governs contralateral behavior, and a redundant both equally guide behavior in full visual space. To explore these alternatives, we analyzed simultaneous bilateral cortex recordings from three macaque monkeys performing visuo-spatial WM task. Each represented targets across field predicted...
Artificial Neural Networks (ANNs) trained on specific cognitive tasks have re-emerged as a useful tool to study the brain. However, ANNs would better aid neuroscience if given network could be easily wide range of for which neural recordings are available. Moreover, unintentional divergent implementations can produce variable results, limits their interpretability. Towards this goal, we present NeuroGym, an open-source Python package that provides large collection customizable test and...
Abstract Brains can gracefully weed out irrelevant stimuli to guide behavior. This feat is believed rely on a progressive selection of task-relevant across the cortical hierarchy, but specific across-area interactions enabling stimulus are still unclear. Here, we propose that population gating, occurring within A1 controlled by top-down inputs from mPFC, support selection. Examining single-unit activity recorded while rats performed an auditory context-dependent task, found encoded relevant...
Abstract Persistent neuronal spiking has long been considered the mechanism underlying working memory, but recent proposals argue for alternative, “activity-silent” substrates memory. Using monkey and human electrophysiology, we show here that attractor dynamics control neural during mnemonic periods interact with activity-silent mechanisms in PFC. This interaction allows memory reactivation, which enhance serial biases spatial Stimulus information was not decodable between trials, remained...
Serial dependence, a behavioral phenomenon where information from previous trials biases current trial reports, is pervasive in working memory tasks. There growing interest its mechanisms, and recent work has shown that individuals with schizophrenia anti-NMDA receptor (NMDAR) encephalitis exhibit reduced serial dependence simple delayed-response Modeling experimental evidence suggest stems the interplay between persistent neural activity short-term synaptic plasticity cortical circuits,...
The ability to successfully retain and manipulate information in working memory (WM) requires that objects' individual features are bound into cohesive representations; yet, the mechanisms supporting feature binding remain unclear. Binding (or swap) errors, where memorized erroneously associated with wrong object, can provide a window intrinsic limits capacity of WM represent key bottleneck our cognitive ability. We tested hypothesis is accomplished via neural phase synchrony swap errors...
Persistently active neurons during mnemonic periods have been regarded as the mechanism underlying working memory maintenance. Alternatively, neuronal networks could instead store memories in fast synaptic changes, thus avoiding biological cost of maintaining an code through persistent firing. Such ‘activity-silent’ codes proposed for specific conditions which are maintained a non-prioritized state, unattended but still relevant short-term memories. A hallmark this is that these can be...
Abstract Serial dependence, how recent experiences bias our current estimations, has been described experimentally during delayed-estimation of many different visual features, with subjects tending to make estimates biased towards previous ones. It proposed that these attractive biases help perception stabilization in the face correlated natural scene statistics as an adaptive mechanism, although this remains mostly theoretical. Color, which is strongly scenes, never studied regard its...
Working memory function is severely limited. One key limitation that constrains the ability to maintain multiple items in working simultaneously so-called swap errors. These errors occur when an inaccurate response fact accurate relative a non-target stimulus, reflecting failure appropriate association or “binding” between features define one object (e.g., color and location). The mechanisms underlying feature binding remain unknown. Here, we tested hypothesis are bound through synchrony...
Alterations in neuromodulation or synaptic transmission biophysical attractor network models, as proposed by the dominant dopaminergic and glutamatergic theories of schizophrenia, successfully mimic working memory (WM) deficits people with schizophrenia (PSZ). Yet, multiple, often opposing circuit mechanisms can lead to same behavioral patterns these models. Here, we critically revise computational experimental literature that links NMDAR hypofunction WM precision loss PSZ. We show...
In the last few decades, field of neuroscience has witnessed major technological advances that have allowed researchers to measure and control neural activity with great detail. Yet, behavioral experiments in humans remain an essential approach investigate mysteries mind. Their relatively modest economic requisites make research attractive accessible experimental avenue for neuroscientists very diverse backgrounds. However, like any enterprise, it its own inherent challenges may pose...
Binding errors, also called swap occur in working memory tasks when the participant fails to report feature of a previously presented target but response is accurate relative non-target stimulus (for instance, s/he reports location green item red item's was be reported). Psychophysical experiments have shown importance these errors [1-3], and they reflect failure system maintain bundled through conjunction features that define one object. How brain able integrate integrated several an single...