A5086570460- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Bone health and treatments
- Bone health and osteoporosis research
- Autoimmune Neurological Disorders and Treatments
- Receptor Mechanisms and Signaling
- Advanced Memory and Neural Computing
- Neural and Behavioral Psychology Studies
- Advanced Neuroimaging Techniques and Applications
- EEG and Brain-Computer Interfaces
- Tryptophan and brain disorders
- Retinal Development and Disorders
- Bone Metabolism and Diseases
- Tensor decomposition and applications
- Mental Health Research Topics
- Vestibular and auditory disorders
- Connective tissue disorders research
- Health and Medical Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Zebrafish Biomedical Research Applications
- Cerebral Venous Sinus Thrombosis
- Social and Demographic Issues in Germany
- Multiple Sclerosis Research Studies
- Employment and Welfare Studies
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2019-2024
Inserm
2021-2024
École Normale Supérieure - PSL
2021-2024
Université Paris Sciences et Lettres
2021-2024
Laboratoire de Neurosciences Cognitives
2021-2024
Laboratoire de Neurosciences Cognitives et Computationnelles
2023
University Medical Center Hamburg-Eppendorf
2009-2023
Universität Hamburg
2009-2023
Berlin Heart (Germany)
2021
Universitat de Barcelona
2021
Abstract A mechanistic understanding of core cognitive processes, such as working memory, is crucial to addressing psychiatric symptoms in brain disorders. We propose a combined psychophysical and biophysical account two symptomatologically related diseases, both linked hypofunctional NMDARs: schizophrenia autoimmune anti-NMDAR encephalitis. first quantified shared memory alterations delayed-response task. In patient groups, we report markedly reduced influence previous stimuli on contents,...
Abstract Recent work has argued that large-scale neural recordings are often well described by patterns of coactivation across neurons. Yet the view variability is constrained to a fixed, low-dimensional subspace may overlook higher-dimensional structure, including stereotyped sequences or slowly evolving latent spaces. Here we argue task-relevant in data can also cofluctuate over trials time, defining distinct ‘covariability classes’ co-occur within same dataset. To demix these...
Abstract. The collagenous constituents of mature bone 30 individuals 22–93 years age were studied by post‐mortem morphological and biochemical analysis. Morphometric evaluation the second lumbar vertebral body revealed striking interindividual differences in mass, mean trabecular density thickness. Collagen extracted from limited pepsin digestion consisted mainly collagen I (92%) V (8%). Immunohistochemistry a distinct distribution these two types within matrix. degree lysyl hydroxylation...
Serial dependence, a behavioral phenomenon where information from previous trials biases current trial reports, is pervasive in working memory tasks. There growing interest its mechanisms, and recent work has shown that individuals with schizophrenia anti-NMDA receptor (NMDAR) encephalitis exhibit reduced serial dependence simple delayed-response Modeling experimental evidence suggest stems the interplay between persistent neural activity short-term synaptic plasticity cortical circuits,...
Abstract Persistent neuronal spiking has long been considered the mechanism underlying working memory, but recent proposals argue for alternative, “activity-silent” substrates memory. Using monkey and human electrophysiology, we show here that attractor dynamics control neural during mnemonic periods interact with activity-silent mechanisms in PFC. This interaction allows memory reactivation, which enhance serial biases spatial Stimulus information was not decodable between trials, remained...
Abstract Recent work has argued that large-scale neural recordings are often well described by low-dimensional ‘latent’ dynamics identified using dimensionality reduction. However, the view task-relevant variability is shared across neurons misses other types of structure underlying behavior, including stereotyped sequences or slowly evolving latent spaces. To address this, we introduce a new framework simultaneously accounts for neurons, trials, time. identify and demix these covariability...
Abstract We report markedly reduced working memory-related serial dependence with preserved memory accuracy in anti-NMDAR encephalitis and schizophrenia. argue that NMDAR-related changes cortical excitation, while quickly destabilizing persistent neural activity, cannot fully account for a reduction of memory-dependent biases. Rather, our modeling results support disruption mechanism operating on longer timescale, such as short-term potentiation.
Abstract Aging is accompanied by a decline of multiple cognitive capacities, including working memory: the ability to maintain information online for flexible control behavior. Working memory involves stimulus-selective neural activity, persisting after stimulus presentation in widely distributed cortical areas. Here, we unraveled mechanisms healthy older adults and patients with mild impairment (MCI), condition associated increased risk developing dementia. We studied sample 19 diagnosed...
Abstract Locomotion in complex environments depends on the precise timing and active control of single paw movements order to adapt steps surface structure coordinate paws. Such motor crucially cerebellum. In turn, cerebellar activity is reported reflect limb movement kinematics, but how action controlled by circuit currently unknown. To address this question, we developed LocoReach: a new task which combines continuous discrete aspects requiring mice walk runged treadmill, where each step...
The visual system processes stimuli over a wide range of spatiotemporal scales, with individual neurons receiving input from tens thousands whose dynamics milliseconds to seconds. This poses challenge create models that both accurately capture computations and are mechanistically interpretable. Here we present model salamander retinal ganglion cell spiking responses recorded multielectrode array captures natural scene slow adaptive dynamics. consists three-layer convolutional neural network...
Alterations in neuromodulation or synaptic transmission biophysical attractor network models, as proposed by the dominant dopaminergic and glutamatergic theories of schizophrenia, successfully mimic working memory (WM) deficits people with schizophrenia (PSZ). Yet, multiple, often opposing circuit mechanisms can lead to same behavioral patterns these models. Here, we critically revise computational experimental literature that links NMDAR hypofunction WM precision loss PSZ. We show...
In the last few decades, field of neuroscience has witnessed major technological advances that have allowed researchers to measure and control neural activity with great detail. Yet, behavioral experiments in humans remain an essential approach investigate mysteries mind. Their relatively modest economic requisites make research attractive accessible experimental avenue for neuroscientists very diverse backgrounds. However, like any enterprise, it its own inherent challenges may pose...
<h3>Objective:</h3> To characterize the clinical features of post-acute stage anti-NMDAR encephalitis (NMDARe), similarities with schizophrenia spectrum disorders (SCZ), and factors that predict cognitive-psychiatric outcomes. <h3>Background:</h3> NMDARe is associated protracted symptoms during a not well known. <h3>Design/Methods:</h3> In this prospective observational study, patients in underwent 3 visits (V1, study entry; V2, 6 months; V3, 12 months) including comprehensive...
Zusammenfassung Die Therapie mit Antikoagulanzien und Thrombolytika ist unter strenger Indikationsstellung ein bewährtes Behandlungskonzept. häufigste Komplikation die Blutung. Dabei gehören intrakranielle Blutungen zu den seltenen, jedoch aus prognostischer Sicht ernsthafteren, vital bedrohlichen Komplikationen. Unter 283 Patienten einem spontanen intrazerebralen Hämatom fanden sich 42 (14,8%), bei denen Blutung einer gerinnungshemmenden aufgetreten war. Bei 24 (8,5%) war es...