A5070890288- Autoimmune Neurological Disorders and Treatments
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Tryptophan and brain disorders
- Epilepsy research and treatment
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2019-2024
Abstract A mechanistic understanding of core cognitive processes, such as working memory, is crucial to addressing psychiatric symptoms in brain disorders. We propose a combined psychophysical and biophysical account two symptomatologically related diseases, both linked hypofunctional NMDARs: schizophrenia autoimmune anti-NMDAR encephalitis. first quantified shared memory alterations delayed-response task. In patient groups, we report markedly reduced influence previous stimuli on contents,...
Serial dependence, a behavioral phenomenon where information from previous trials biases current trial reports, is pervasive in working memory tasks. There growing interest its mechanisms, and recent work has shown that individuals with schizophrenia anti-NMDA receptor (NMDAR) encephalitis exhibit reduced serial dependence simple delayed-response Modeling experimental evidence suggest stems the interplay between persistent neural activity short-term synaptic plasticity cortical circuits,...
Abstract We report markedly reduced working memory-related serial dependence with preserved memory accuracy in anti-NMDAR encephalitis and schizophrenia. argue that NMDAR-related changes cortical excitation, while quickly destabilizing persistent neural activity, cannot fully account for a reduction of memory-dependent biases. Rather, our modeling results support disruption mechanism operating on longer timescale, such as short-term potentiation.