A5029926003- Asthma and respiratory diseases
- Pharmaceutical studies and practices
- SARS-CoV-2 and COVID-19 Research
- Phenothiazines and Benzothiazines Synthesis and Activities
- Immunotherapy and Immune Responses
- Energetic Materials and Combustion
- Synthesis and Characterization of Heterocyclic Compounds
- Iron Metabolism and Disorders
- Cytomegalovirus and herpesvirus research
- Heavy Metal Exposure and Toxicity
- Quinazolinone synthesis and applications
- Synthesis and Biological Evaluation
- Gastroesophageal reflux and treatments
- Cytokine Signaling Pathways and Interactions
- CAR-T cell therapy research
- RNA Interference and Gene Delivery
- Vitamin D Research Studies
- CRISPR and Genetic Engineering
- Molecular Biology Techniques and Applications
- vaccines and immunoinformatics approaches
- COVID-19 Clinical Research Studies
- Influenza Virus Research Studies
- Trace Elements in Health
- X-ray Diffraction in Crystallography
- thermodynamics and calorimetric analyses
Sechenov University
2024
Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology
2024
D. Mendeleyev University of Chemical Technology of Russia
2014-2021
Institute of Immunology and Physiology
2021
Federal Medical-Biological Agency
2020
First vaccines for prevention of Coronavirus disease 2019 (COVID-19) are becoming available but there is a huge and unmet need specific forms treatment. In this study we aimed to evaluate the anti-SARS-CoV-2 effect siRNA both in vitro vivo.To identify most effective molecule out panel 15 silico designed siRNAs, an screening system based on vectors expressing SARS-CoV-2 genes fused with firefly luciferase reporter gene SARS-CoV-2-infected cells was used. The potent siRNA, siR-7, modified by...
Влияние локального подавления экспрессии гена Stat3 на нейтрофильное воспаление легких в экспериментальной модели мышах1 Федеральное государственное бюджетное учреждение «Государственный научный центр «Институт иммунологии» Федерального медико-биологического агентства, 115522, г.Москва, Российская Федерация 2 образовательное высшего образования Московская государственная академия ветеринарной медицины и биотехнологии -МВА имени К.И.Скрябина Министер-
Every year, a seasonal increase in the incidence of respiratory infections is registered Russian Federation, primarily among children. It significantly increases burden on outpatient pediatric service. especially important to optimize daily practice pediatricians by developing algorithms and updating treatment protocols, as well creating conducting training programs. Fever leading symptom acute viral one most common reasons for seeking help services. Leading experts field therapy pediatrics...
Abstract By replacing the pyrazolyl fragment in 3,6‐bis(3,5‐dimethyl‐1H‐pyrazol‐1‐yl)‐1,2,4,5‐tetrazine with 3‐nitro‐1,2,4‐triazol‐5‐one (NTO), both mono‐ and disubstitution products have been synthesized. Further interaction of obtained compounds O‐ N‐nucleophiles led to preparation a number polynitrogen tetrazine derivatives, including 2‐[6‐amino‐1,2,4,5‐tetrazin‐3‐yl]‐5‐nitro‐2,4‐dihydro‐3H‐1,2,4‐triazol‐3‐one 5‐nitro‐2‐...
Козлов И.Б. 1 , Ватазин А
МИР 19 ® -первый в мире специфический противовирусный препарат для лечения COVID-19: разработка и доклинические исследования 1 Федеральное государственное бюджетное учреждение «Государственный научный центр «Институт иммунологии» Федерального медико-биологического агентства, 115522, г.Москва, Российская Федерация 2 автономное образовательное учр еждение высшего образования «Российский национальный исследовательский медицинский университет имени Н.И.Пирогова» Министерства здравоохранения...
Technologies for creating genotherapeutic drugs using synthetic 5’-phosphorylated RNA oligonucleotides are being actively developed. The synthesis of these is complicated by the methods selection post-synthetic purification HPLC. We propose combination HPLC efficient target product. structure obtained was confirmed LC-MS.
Булушева И.А. 1 , Козлов И
Козлов И.Б. 1 , Лебедин М
Standartnaya terapiya bronhial'noj astmy (BA) vklyuchaet naznachenie β2-agonistov. Izmenenie funkcional'noj aktivnosti β2-adrenoreceptora associirovano s polimorfizmom gena ADRB2 i svyazano nizkim terapevticheskim otvetom na β2-agonisty. Vyyavlenie nositelej klinicheski znachimyh variantov pomozhet izbezhat' neeffektivnogo lecheniya posluzhit osnovaniem dlya naznacheniya al'ternativnoj terapii. Cel'yu issledovaniya bylo ocenit' klinicheskuyu znachimost' associirovannyh β2-agonisty...
Standard asthma therapy includes prescription of β2-agonists. Changes in the functional activity β2-adrenergic receptor are associated with ADRB2 genepolymorphism and related to low therapeutic response Identification carriers clinically significant gene variants will help avoidineffective treatment prescribe an alternative therapy. This study aimed assess clinical significance polymorphisms (Arg16Gly andGln27Glu) β2-agonists group patients. We subjected a small adult nonsmoking patients(n =...