A5101467788- Immune cells in cancer
- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Slime Mold and Myxomycetes Research
- Histone Deacetylase Inhibitors Research
- Advancements in Battery Materials
- CAR-T cell therapy research
- Selenium in Biological Systems
- Biocrusts and Microbial Ecology
- Photonic and Optical Devices
- Powder Metallurgy Techniques and Materials
- Sirtuins and Resveratrol in Medicine
- Metal Extraction and Bioleaching
- Mycorrhizal Fungi and Plant Interactions
- Mangiferin and Mango Extracts
- Advanced Photonic Communication Systems
- Genetics, Aging, and Longevity in Model Organisms
- Toxoplasma gondii Research Studies
- Bone Metabolism and Diseases
- Electron and X-Ray Spectroscopy Techniques
- Connexins and lens biology
- Autophagy in Disease and Therapy
- Chemokine receptors and signaling
- Nanoplatforms for cancer theranostics
Xiangya Hospital Central South University
2025
Central South University
2025
Northeast Normal University
2021-2023
Duke Medical Center
2011-2022
Duke University Hospital
2019-2022
Xi'an Jiaotong University
2022
Silicon Technologies (United States)
2022
Southern University of Science and Technology
2022
Duke University
2018-2019
Seismological Bureau of Shanghai
2002
Abstract Tumor-associated myeloid cells regulate tumor growth and metastasis, their accumulation is a negative prognostic factor for breast cancer. Here we find calcium/calmodulin-dependent kinase (CaMKK2) to be highly expressed within intratumoral in mouse models of cancer, demonstrate that its inhibition suppresses by increasing effector CD8 + T immune-stimulatory subsets. macrophages (TAMs) isolated from Camkk2 −/− mice higher levels chemokines involved the recruitment compared WT....
Language deficits, restricted and repetitive interests, social difficulties are among the characteristics of autism spectrum disorder (ASD). Machine learning neuroimaging have also been combined to examine ASD. Utilizing bibliometric analysis, this study examines current state hot topics in machine for A research analysis application ASD trends, including trends most popular topics, as well proposed future directions research. From 1999 2023, Web Science Core Collection (WoSCC) was searched...
Myeloid-derived suppressor cells (MDSCs) are a hetero geneous group of cells, which can suppress the immune response, promote tumor progression and impair efficacy immunotherapies. Consequently, pharmacological targeting MDSC is emerging as new immunotherapeutic strategy to stimulate natural anti-tumor response potentiate Herein, we leveraged genetically modified models small molecule inhibitor validate Calcium-Calmodulin Kinase 2 (CaMKK2) druggable target control accumulation in...
A styryl phosphonate ester (SPE) collector was used to improve the flotation performance of ilmenite, and adsorption mechanism model were revealed established, respectively. Microflotation tests showed that SPE exhibited a stronger collecting ability for ilmenite than traditional styrene phosphonic acid (SPA). Zeta potential measurements both SPA could negatively shift zeta while had more effects SPA, suggesting SPE. The analysis X-ray photoelectron spectroscopy confirmed chemisorption onto...
To evaluate the potential role that FoxO transcription factors play in modulating resveratrol's protective effects against oxidative stress lens epithelial cells.Primary human or porcine cells (LECs) were treated with resveratrol (RES) 25 μM and incubated under either physiologic (5%) chronic hyperoxic (40%) oxygen conditions. Acute was applied using 600 H(2)O(2). Changes expression of FoxO1A, FoxO3A, FoxO4 analyzed. The production intracellular reactive species (iROS), SA-β-galactosidase...
Abstract Hematopoietic stem and progenitor cells (HSPCs) are predominantly quiescent in adults, but proliferate response to bone marrow (BM) injury. Here, we show that deletion of Ca 2+ /calmodulin (CaM)-dependent protein kinase 2 (CaMKK2) promotes HSPC regeneration hematopoietic recovery following radiation Using Camkk2-enhanced green fluorescent (EGFP) reporter mice, found Camkk2 expression is developmentally regulated HSPC. Deletion results a significant downregulation genes affiliated...
Data from both animal models and humans have demonstrated that effector memory T cells (TEM) central (TCM) unprimed donors decreased ability to induce graft-versus-host disease (GVHD). Allospecific TEM primed do not mediate GVHD. However, the potential of alloreactive TCM GVHD is clear. In this study, we sought answer question using a novel model induced by cell receptor (TCR) transgenic OT-II cells. Separated mice immunized with OVA protein 8 weeks earlier, allospecific CD44high were able...
Alloreactive donor T cells undergo extensive metabolic reprogramming to become activated and induce graft-versus-host disease (GVHD) upon alloantigen encounter. It is generally thought that glycolysis, which promotes cell growth clonal expansion, employed in this process. However, conflicting data have been reported regarding the requirement of glycolysis cell-mediated GVHD due lack cell-specific treatments using inhibitors. Importantly, previous studies not evaluated whether...
Aim: To quantitatively and sensitively investigate the biodistribution of immune cells after systemic administration. Methods: Immune were loaded with plasmonic gold nanostars (GNS) tracking probes. Inductively coupled plasma mass spectrometry (ICP-MS) was used for quantitative measurement two-photon photoluminescence (TPL) high-resolution sensitive optical imaging. Results: GNS nanoparticles successfully into without negative effect on cellular vitality. Liver spleen identified to be major...
采用离子交换加固相烧结法制备出富锂锰基正极材料Li1.2Mn0.54Co0.13Ni0.13NaxO2,利用球差校正扫描透射电子显微镜（STEM）、X射线能谱（EDS）、电子能量损失谱（EELS）等分析手段对材料表面结构与成分展开表征。结果表明：镍（Ni）在样品表面存在选择性富集（垂直于锂扩散通道的表面,如（200）面）,倾向扩散进入锂离子层,并导致表面出现层状结构到岩盐相（rocksalt,Fm3m）结构转变;而钴（Co）在所观察的（001）、（200）表面均存在不同程度的富集,且集中在过渡金属层。进一步研究发现,表面钴（Co）富集不利于层状结构的稳定,时效后样品的（001）面观察到明显的表面重构,存在数量较多的过渡金属（TM）-锂（Li）反位缺陷与岩盐相结构区域。
We present and demonstrate an integrated approach to make low-cost high-speed half-duplex optical transceiver with rapid reconfigurability. A single Distributed-Feedback (DFB) diode is employed as the unified E/O-O/E device, which dynamically biased laser or photodetector in transmitter receiver mode. The bias for DFB transmit/receive (T/R) signal path are provided by a custom-designed reconfigurable CMOS chip, contains biasing circuitry, T/R switch burst-mode transimpedance amplifier...
Abstract Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of cells, which can suppress the immune response, promote tumor progression and impair efficacy immunotherapies. Consequently, pharmacological targeting MDSC is emerging as new immunotherapeutic strategy to stimulate natural anti-tumor response potentiate Herein, we leveraged genetically modified models small molecule inhibitor validate Calcium-Calmodulin Kinase 2 (CaMKK2) druggable target control accumulation in...