Mizael Machado

ORCID: 0000-0002-2029-884X
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About
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Research Areas
  • Plant Toxicity and Pharmacological Properties
  • Helminth infection and control
  • Venomous Animal Envenomation and Studies
  • Plant and fungal interactions
  • Toxin Mechanisms and Immunotoxins
  • Microbial infections and disease research
  • Healthcare and Venom Research
  • Dermatological and Skeletal Disorders
  • Botanical Research and Chemistry
  • Rabies epidemiology and control
  • Coccidia and coccidiosis research
  • Insect and Pesticide Research
  • Parathyroid Disorders and Treatments
  • Phytochemistry Medicinal Plant Applications
  • Allelopathy and phytotoxic interactions
  • Oral and gingival health research
  • Alkaline Phosphatase Research Studies
  • Hip disorders and treatments
  • Silymarin and Mushroom Poisoning
  • Muscle and Compartmental Disorders
  • Agricultural safety and regulations
  • Otitis Media and Relapsing Polychondritis
  • Cardiovascular Effects of Exercise
  • Food Allergy and Anaphylaxis Research
  • Actinomycetales infections and treatment

Instituto Nacional de Investigación Agropecuaria
1973-2024

Universidade de Brasília
2018-2024

Vascular mineralization is a hallmark of enzootic calcinosis. Histopathological, ultrastructural, and immunohistochemical investigations were performed on the external carotid arteries seven sheep naturally poisoned by Nierembergia veitchii. Histologically, moderate to marked hyperplasia tunica intima was observed without mineralization. The media exhibited mild severe osteochondroid metaplasia. Sheep with calcinosis showed arterial overexpression osteopontin tissue-nonspecific alkaline...

10.1177/03009858221098430 article EN Veterinary Pathology 2022-05-19

We investigated 2 outbreaks of osteomalacia as a result phosphorus (P) deficiency in herds lactating beef cows grazing subtropical native pastures Uruguay. Cows exhibited pica, difficulty to stand and walk, rib fractures, body weight loss even with adequate forage availability. Osteopenia severe were observed on gross histologic examination. The concentrations bicarbonate-extractable P soil (4.0, 4.1 mg P/kg), total pasture (0.9, 1.1 g inorganic serum (1.0, 0.71 mmol P/L), bone (73 P/mL) all...

10.1177/10406387211025828 article EN Journal of Veterinary Diagnostic Investigation 2021-06-23

An outbreak of acute febrile syndrome associated with coagulopathy and severe pancytopenia occurred in cattle grazing paddocks high infestation by Adiantopsis chlorophylla. The administration the plant to a calf reproduced same signs lesions seen spontaneous cases. Similar syndromes are caused ptaquiloside from bracken fern. Traces ptaquiloside-like molecule caudatoside were detected together 0.03-0.24 mg/g it's degradation product pterosin A, dry fronds plant. In conclusion, A. chlorophylla...

10.1016/j.toxcx.2020.100024 article EN cc-by Toxicon X 2020-01-23

ABSTRACT: This study reports four outbreaks of Cestrum axillare poisoning in cattle. Outbreaks occurred farms the Distrito Federal, Goiás, and Minas Gerais states during dry season, affecting cows heifers, with a mortality rate 1 to 14,28%. Poisoned animals showed neurological signs recumbency, followed by death within 12 hours, some were found dead. Gross histological lesions typical acute hepatotoxicity hepatomegaly, enhancement lobular pattern, centrilobular massive necrosis. seems be...

10.1590/1678-5150-pvb-7399 article EN cc-by Pesquisa Veterinária Brasileira 2024-01-01

ABSTRACT: We described the first case of rhinofacial pythiosis with dissemination in an adult horse Uruguay. The affected presented a partially circumscribed mass measuring 30 x 23 9 cm affecting right side face involvement cutaneous, subcutaneous, and muscular tissues, nasal cavity, adjacent structures. At postmortem examination, main lesions were “kunkers” characterized by pyogranulomatous eosinophilic dermatitis, Splendore-Hoeppli reaction numerous intralesional hyphae immunolabeling...

10.1590/0103-8478cr20240022 article EN Ciência Rural 2024-09-02

At clinical examination, a 5-year-old male domestic short-haired cat exhibited painful swelling and erythema of the pinnae both ears. Microscopically, lesions on were composed diffuse granulomatous chondritis with degeneration necrosis pinnal cartilage. Numerous mast cells also observed within surrounding inflammatory lesion. Immunohistochemistry showed mixed infiltrate characterised by predominance macrophages (CD68+, MAC 387+ Lysozyme+), T lymphocytes (CD3+), some B (CD79α+) neutrophils....

10.1556/004.2019.009 article EN Acta Veterinaria Hungarica 2019-03-01

Background: Toxic reactions due bee stings in human, companion animals, food animals and wild are sporadically reported. Accidents involving bees have been occurring urban rural areas since 1956, when African were introduced Brazil, forming populations of aggressive hybrid Africanized bees. Their sting cause local systemicreactions, which include dermatologic reactions, anaphylactic toxic systemic before death. The aim this article is to describe the clinical pathological aspects two dogs...

10.22456/1679-9216.86346 article EN cc-by ACTA SCIENTIAE VETERINARIAE 2018-06-26

syn.Nierembergia repens) in South America (Santos et al., 2012), Cestrum diurnum North America, Trisetum flavescens Europe, and Solanum torvum Oceania (Mello, 2003).S. glaucophyllum C. contain 1-alpha, 25-dihydroxyvitamin D3 [1α,25(OH)2D3] (calcitriol) (Wasserman 1976;Mello, 2003).Although the chemical structure of toxic compound Nierembergia spp. is unknown, N. veitchii possesses a similar vivo biological activity to calcitriol.

10.1590/1678-4162-11795 article EN cc-by Arquivo Brasileiro de Medicina Veterinária e Zootecnia 2020-08-01

This study investigated two outbreaks of spontaneous poisoning by Baccharis coridifolia (Asteraceae) in early-weaned beef calves Tacuarembó, Uruguay. A total 34 affected showed signs salivation, anorexia, apathy, marked dehydration, and diarrhea. Deaths occurred 36–72 h after consumption mortality varied from 37.5% to 43.3% for outbreak 1 2, respectively. The main pathological findings include diffuse severe necrosis the prestomachs lymphoid tissues. Ultrastructurally, epithelial cells rumen...

10.3390/toxins15120681 article EN cc-by Toxins 2023-12-01
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