A5040840069- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Venous Thromboembolism Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Heart Failure Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Cardiomyopathy and Myosin Studies
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Cardiovascular Function and Risk Factors
- COVID-19 Clinical Research Studies
- Intensive Care Unit Cognitive Disorders
- Autophagy in Disease and Therapy
- Cardiac Structural Anomalies and Repair
- Trace Elements in Health
- Pharmaceutical Practices and Patient Outcomes
- Trypanosoma species research and implications
- Cardiac Health and Mental Health
- Regional Development and Management Studies
- Cardiac Ischemia and Reperfusion
- Mitochondrial Function and Pathology
- Infective Endocarditis Diagnosis and Management
University Hospital Dubrava
2017-2025
University of Zagreb
2015-2022
Klinička bolnica Merkur
2017
Mitochondrial dysfunction is one of key factors causing heart failure. We performed a comprehensive analysis expression mitochondrial quality control (MQC) genes in failure.Myocardial samples were obtained from patients with ischemic and dilated cardiomyopathy terminal stage failure donors without disease. Using quantitative real-time PCR, we analysed total 45 MQC belonging to biogenesis, fusion-fission balance, unfolded protein response (UPRmt), translocase the inner membrane (TIM)...
Mitochondria are involved in crucial homeostatic processes the cell: production of adenosine triphosphate and reactive oxygen species, release pro-apoptotic molecules. Thus, cell survival depends on maintenance proper mitochondrial function by quality control. The most important control mechanisms unfolded protein response, mitophagy, biogenesis, fusion-fission dynamics. This review deals with heart diseases, especially myocardial infarction failure. Some previous studies have demonstrated...
This study was designed to examine the association between myocardial concentrations of trace elements Cu, Fe, Mn, Mo, and Zn expression mitochondrial unfolded protein response (UPRmt) age patients who received heart transplantation or a left-ventricular assist device (ageHTx/LVAD). Inductively coupled plasma mass spectrometry used determine concentration in myocardium control subjects undergoing (LVAD) implantation. We ELISA quantify UPRmt proteins 4-Hydroxynonenal (4-HNE), which served as...
Liver cirrhosis is an increasing public health problem and a major cause of morbidity mortality. Accordingly, cirrhotic cardiomyopathy, frequently underdiagnosed condition, becoming growing problem. In the last 20 years, cardioselective biomarkers have been investigated for their diagnostic prognostic properties numerous conditions. The aim this article to review literature on relationship between most commonly used (cardiac troponins I T, N-terminal pro-B-type natriuretic peptide, brain...
In children, congenital heart defects represent the primary cause of increased serum troponin I. The elimination process cardiac I from bloodstream and factors influencing this remain unknown. objective study was to explore role as an indicator damage in children both urine, a concept previously investigated adults.
Type III transforming growth factor (TGFβ) receptor (TGFβrIII) modulates TGFβ superfamily signaling. Its tumor tissue expression is downregulated in human breast cancer. We determined (indirect ELISA) plasma levels of the soluble (sTGFβrIII) 47 women with cancer (AJCC stages 0-IIB) (cases) pre-surgery and over two months after surgery, 36 healthy (controls). Plasma sTBFβrIII was lower cases than controls (age-adjusted difference -29.7 ng/mL, p < 0.001), discriminated between disease health...
Background: It has recently been shown that cardiac-specific troponin I concentrations in first morning urine samples can be measured with commercially available tests. Due to their accumulation the urine, scientific papers indicate a potential predictive value for cardiovascular diseases. Therefore, aim of this study was compare concentration cardiac patients severe aortic stenosis and healthy population. Patients Methods: Blood were collected from 34 individuals (17 female) at University...
Background: The use of high-sensitive cardiac troponin T (hsTnT) in urine as a marker damage children has not yet been reported. Elimination troponins is dependent on renal function; persistently increased serum hsTnT concentrations were observed among individuals with impaired function. aim this study was to investigate and levels its correlation infants younger than 24 months age after surgery. Methods: This conducted 90 under who divided into three groups. experimental group consisted...
Background. Drug-drug interactions (DDIs) are one potential cause of adverse drug events. Very little has been done to study the relationship between DDIs in patients (p) with atrial fibrilla-tion (AF) on direct oral anticoagulants (DOACs). Many elimi-nated by kidneys, so they can accumu-late if their dose is not adapted kid-ney function. DDI particular type error that result events (ADEs) exposed and was aim this study.Materials Methods. A total 50 pa-tients AF DOACs (25 dabigatran 25...
Abstract Objectives COVID-19 in it is more severe form characterized by a hyperinflammatory condition, hypercoagulation state and the appearance of pulmonary microembolism. In this study we wanted to correlate levels D-Dimer, protein C, S antithrombin 3 with severity disease clinical outcome. Methods We included 134 patients who were divided groups regarding oxygen support (high flow therapy, mechanical ventilation supplementation nasal cannula or mask). Results Concentration activity C are...