A5087596866- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pediatric health and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Advanced Chemical Sensor Technologies
- Inhalation and Respiratory Drug Delivery
- Respiratory Support and Mechanisms
- Gut microbiota and health
- Eosinophilic Esophagitis
- Telomeres, Telomerase, and Senescence
- Adolescent and Pediatric Healthcare
- Moringa oleifera research and applications
- Cardiovascular Syncope and Autonomic Disorders
- Herbal Medicine Research Studies
- Tracheal and airway disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pharmaceutical studies and practices
- COVID-19 Clinical Research Studies
- Healthcare Systems and Public Health
- Heart Rate Variability and Autonomic Control
- Non-Invasive Vital Sign Monitoring
- Seaweed-derived Bioactive Compounds
- Neuropeptides and Animal Physiology
- Neonatal Respiratory Health Research
University of Liège
2017-2024
Centre Hospitalier Universitaire de Liège
2018-2023
Iowa State University
1999
American College of Surgeons
1999
Rationale: Analysis of exhaled breath for asthma phenotyping using endogenously generated volatile organic compounds (VOCs) offers the possibility noninvasive diagnosis and therapeutic monitoring. Induced sputum is indeed not widely available markers neutrophilic are still lacking.Objectives: To determine whether analysis VOCs can be a surrogate marker recognition inflammatory phenotypes.Methods: We conducted prospective study on 521 patients with recruited from University Asthma Clinic...
Asthmatics and patients with chronic obstructive pulmonary disease (COPD) have more severe outcomes viral infections than people without disease.
Randomized control trials performed in selected populations of severe eosinophilic asthmatics have shown that mepolizumab, an anti-IL5 therapy, was able to reduce exacerbations and OCS maintenance dose some studies, improve asthma lung function.The aim this study confirm the results RCTs real-life a population 116 treated with mepolizumab who were followed up at clinic every month for least 18 months. Severe underwent FENO, function, quality life questionnaires, sputum induction gave blood...
The technique of sputum induction and processing is a recognized non-invasive method allowing the collection analysis cells from airways, which interesting in various respiratory diseases like asthma, chronic obstructive pulmonary disease (COPD), cough, or idiopathic fibrosis. This well tolerated, safe non-invasive, but currently limited to research services specialized centers clinical practice because it technically demanding, time-consuming, requires trained staff. success rate about 80%....
1. The chicken possesses adrenergic inhibitory mechanisms as evidenced by (a) vasodepression induced isopropylnorepinephrine, and (b) vasomotor reversal following appropriate doses of Dibenzyline. 2. Large the β-haloalkylamine ergot alkaloid blocking agents are required to effect blockade in chicken. 3. Dibenamine is capable producing hen, but it considerably less effective than 4. Dibenzyline can block sympathetic reflexes sympathoadrenal discharge addition administered sympathomimetics. 5....
An objective of the Severe Heterogeneous Asthma Registry, Patient-centered (SHARP) is to produce real-world evidence on a pan-European scale by linking nonstandardised, patient-level registry data. Mepolizumab has shown clinical efficacy in randomised controlled trials and prospective studies could therefore serve as proof principle for this novel approach. The aim present study was harmonise data from 10 national severe asthma registries characterise patients receiving mepolizumab, assess...
Several clinical trials have demonstrated that anti-IL-5(R) biologics were able to improve lung function, asthma control and chronic oral corticosteroid exposure reduce exacerbations among eosinophilic asthmatic patients. However, a certain variability in responses was brought light. Our study aimed at evaluating the role of baseline sputum eosinophils identifying super-responders mepolizumab benralizumab. reinforces importance examine patients suffering from severe before starting biologic...
The technique of sputum induction and processing is a recognized non-invasive method allowing the collection analysis cells from airways, which interesting in various respiratory diseases like asthma, chronic obstructive pulmonary disease (COPD), cough, or idiopathic fibrosis. This well tolerated, safe non-invasive, but currently limited to research services specialized centers clinical practice because it technically demanding, time-consuming, requires trained staff. success rate about 80%....
Abstract Background Elderly asthmatics represent an important group that is often excluded from clinical studies. In this study we wanted to present characteristics of older than 70 years old as compared younger patients. Methods We conducted a retrospective analysis on series 758 subdivided in three groups: lower 40, between 40 and 70. All the patients who had successful sputum induction were included study. Results Older higher Body Mass Index, less active smokers more treated with Long...
Abstract Background Severe asthma (SA) may require frequent courses or chronic use of oral corticosteroids (OCS), inducing many known side effects and complications. Therefore, it is important to identify risk factors OCS in SA, considering the heterogeneity clinical inflammatory phenotypes. Another aim present analysis characterize a subpopulation severe asthmatics, whom blood eosinophil counts (BEC) remain elevated despite treatment. Methods In cross-sectional 982 SA patients enrolled...
<b>Background:</b> Biotherapies targeting IL-5 allow a tangible improvement of asthma but all patients do not respond the same way to these treatments. Even if high blood eosinophil counts (BEC) appear associated with reduction in exacerbations, we lack biomarkers for prediction remission after very expensive Goal: The purpose this study is find therapy sputum severe eosinophilic asthmatics. Methods: This observational included 52 asthmatics initiated an anti-IL-5. Remission was defined one...
<title>Extract</title> Induced sputum is an easy, non-invasive, reproducible and inexpensive tool to collect cells from airways. It has been used for monitoring the airway inflammation guide treatment in context of asthma with success since years now recognised as a gold standard management severe patients by world guidelines (<ext-link>https://ginasthma.org</ext-link>).
<b>Rationale:</b> Asthma is associated with accelerated rate of lung function (FEV<sub>1</sub>) decline. <b>Objectives:</b> To determine predictive factors % predicted FEV<sub>1</sub> decline in asthma. <b>Methods:</b> A retrospective study was conducted 229 asthmatics recruited from the University Clinic Liège. Subjects had at least two consecutive visits post-BD and minimum one year between them. multivariable linear regression analysis order to come up a model for <b>Results:</b> Decline...
<b>Introduction:</b> Refractory asthma still represents a certain percentage of asthmatic patients despite the use high medication. There is need for new therapeutics allowing better control. Probiotics are able to modulate intestinal microbiota homeostasis as well immune system, moderate inflammation and appeared be very tolerated safe. <b>Goal:</b> The goal this study was assess if probiotics have beneficial impact on refractory asthma. <b>Methods:</b> randomized double blind placebo...