We have systematically explored how plasmonic effects influence the characteristics of polymer photovoltaic devices (OPVs) incorporating a blend poly(3-hexylthiophene) (P3HT) and [6,6]-phenyl-C61-butyric acid methyl ester (PCBM). blended gold nanoparticles (Au NPs) into anodic buffer layer to trigger localized surface plasmon resonance (LSPR), which enhanced performance OPVs without dramatically sacrificing their electrical properties. Steady state photoluminescence (PL) measurements...

In this study, we have explored how light trapping efficiency can be enhanced by using gold nanoparticles (Au NPs) of various sizes and shapes on the front polymer solar cells (PSCs) with active layer—blends poly(3-hexyl thiophene) [6,6]-phenyl-C61-butyric acid methyl ester. The light-concentrating behavior was after had incorporated nanospheres or nanorods into anodic buffer layer [based poly(3,4-ethylenedioxythiophene):polystyrenesulfonate] to trigger localized surface plasmon resonance...

An energy upconversion system based on triplet-triplet annihilation exploiting an organic triplet sensitizer is devised and has achieved a white-light emission with low power laser excitation.

Reactive oxygen species (ROS) are important factors in many clinical diseases. However, direct delivery of antioxidant enzymes into cells is difficult due to poor cell uptake. A proper design by nanoparticles very desirable for therapeutic purposes. To overcome the barrier problem, a designed mesoporous silica nanoparticle (MSN) system with attached TAT-fusion denatured enzyme enhancing membrane penetration has been developed. Simultaneous two up-downstream enzymes, superoxide dismutase...

Reactive oxygen species (ROS)-induced oxidative stress leads to neuron damage and is involved in the pathogenesis of chronic inflammation neurodegenerative diseases (NDs), such as Alzheimer's, Parkinson's, amyotrophic lateral sclerosis. Researchers, therefore, are looking for antiinflammatory drugs gene therapy approaches slow down or even prevent neurological disorders. Combining therapeutics has shown a synergistic effect treatment human diseases. Many nanocarriers could be designed...

In the present study, we demonstrate synthesis and applications of multifunctional gold nanorod-based probes for specific targeting noninvasive imaging based on localized heating generated by nanorods after NIR irradiation. The structural design probe consists MUA (11-mercaptoundecanoic acid)-capped covalently linked with low-molecular-weight chitosan oligosaccharide (Mw ∼5000) via carbodiimide (EDC) coupling agent. This surface modification is performed complete replacement toxic CTAB...

Mesoporous silica nanoparticles (MSNs) have received intensive recent interest as multi-functional nanocarriers for biological cells and tissues. Their cell uptake intracellular distribution depends on the surface charge they carry. We develop a new approach monitoring their localization by measuring local pH value of MSNs. synthesized ratiometric pH-sensor loaded with mesoporous that can map location MSN through site in HeLa cells. Positively charged MSN-TA was found to locate higher...

Galectin-3 has been reported to regulate the functions of a number immune cell types. We previously that galectin-3 is translocated immunological synapses in T cells upon T-cell receptor engagement, where it associates with ALG-2-interacting protein X (Alix). Alix known coordinate endosomal sorting complex required for transport (ESCRT) promote human immunodeficiency virus (HIV)-1 virion release. hypothesized plays role HIV-1 viral budding. Cotransfection Jurkat line and plasmids resulted...

Here, we report the facile preparation of tunable magnetic Ni-doped near-infrared (NIR) quantum dots (MNIR-QDs) as an efficient probe for targeting, imaging, and cellular sorting applications. We synthesized MNIR-QDs via a hot colloidal synthesis approach to yield monodisperse QDs. These hydrophobic QDs were structurally compositionally characterized further functionalized with amino-PEG carboxyl-PEG improve their biocompatibility. Since are known be toxic due presence cadmium, have...

Core/shell quantum dots (CdSe/Zns) conjugated with various nuclear localization signaling (NLS) peptides, which could facilitate the transportation of across plasma membrane into nucleus, have been utilized to investigate uptake mechanism targeted delivery. Because their brightness and photostability, it was possible trace trajectories individual in living cells using both confocal total internal reflection microscopes. We found that, when were added a cell culture, peptide-coated entered...

In this study, the light diffraction of temporal focusing multiphoton excitation microscopy (TFMPEM) and patterning nonlinear structured-illumination (NSIM) can be simultaneously accurately implemented via a single high-resolution digital micromirror device. The lateral axial spatial resolutions TFMPEM are remarkably improved through second-order NSIM projected structured light, respectively. experimental results demonstrate that enhanced from 397 nm to 168 (2.4-fold) 2.33 μm 1.22...

The blinking phenomena of the quantum dots have been utilized in super-resolution localization microscopy to map out locations individual on a total internal reflection microscope. Our result indicated that reconstructed image agreed with topographic measured by atomic force microscopy. Because superior optical properties dots, high resolution can be achieved shorter acquisition time larger detected photon numbers. When cells were labeled sub-cellular structures could clearly seen images...

A new resolution-enhanced surface plasmon resonance (SPR) biosensor offers a tenfold improvement in resolution compared with conventional SPR biosensors the detection of coverage biomaterials. The proposed optical biosensor, based on attenuated total-reflection method, excites both plasmons and particle to enhance local electromagnetic field by control size volume fraction embedded Au nanoparticles increase device. design is Maxwell-Garnett model Fresnel equations, device fabricated...

In this study, the exciton lifetime images within photoactive layers of poly(3-hexylthiophene) (P3HT) and [6,6]-phenyl-C61-butyric acid methyl ester (PCBM) are revealed by confocal optical microscopy combined with fluorescence module. The reveal that active during slow solvent evaporation provide 3D pathways for charge transport concentration gradient through film which reflects better cell performance. This technique offers a great help to investigate optical-physical property without...

This paper reports the development of a novel force measurement device based on polymeric nanopillar arrays. The was fabricated by process combining nanosphere lithography, oxygen plasma treatment, deep etching and nano-molding. Well-ordered arrays with various diameters aspect ratios were used as cell culture substrates. Cell traction forces measured deflection nanopillars. Since location nanopillars can be monitored at all times, this allows for evolution adhesion over time.

Abstract The formation of focal adhesions on various sizes fibronectin patterns, ranging from 200 μm to 250 nm, was systematically investigated by total internal reflection fluorescence microscopy and super‐resolution imaging. It found that cells adhered spread these micro/nanopatterns, forming adhesions. On a micrometer scale the shape elongated. However, nanometer scale, became dotlike. To further explore distribution adhesion proteins formed surfaces, localization‐based imaging technique...

Abstract A simple, sensitive, and highly specific lipid targeting Raman probe (Nile red coated silver nanoparticles) has been developed to image living nematode Caenorhabditis elegans ( C. ). Our idea of imaging lipids in is combine the specificity fluorescent dye, Nile red, enhanced scattering on nanoparticles. strategy involves fabrication a probe, which incorporated into intracellular intestinal granules by incubating these worms solution containing probes, resulting an uptake subsequent...

Replication forks are vulnerable to wayward nuclease activities. We report here our discovery of a new member in guarding genome stability at replication forks. previously isolated Drosophila mutation, wuho (wh, no progeny), characterized by severe fertility defect and affecting expression protein (WH) family conserved proteins with multiple WD40 repeats. Knockdown WH siRNA Drosophila, mouse, human cultured cells results DNA damage strand breaks apoptosis through ATM/Chk2/p53 signaling...

A coupled waveguide-surface plasmon resonance (CWSPR) biosensor based on the Kretschmann configuration is developed. The CWSPR couples surface (SPR) mode and waveguide generates two sharp dips in reflectivity spectrum. proposed not only retains same sensing sensitivity as that of a conventional SPR device but also yields sharper spectrum therefore provides an improved measurement precision. enable refractive indices thicknesses both self-assembled monolayer layer human serum albumin absorbed...

The reflection resonance spectrum of a subwavelength diffraction-grating-coupled waveguide is used to analyze biomolecular interactions in real time. By detecting this wavelength shift, the optical biosensor provides ability identify kinetics interaction on an on-line basis without need for extrinsic labeling biomolecules. A theoretical analysis performed. with narrow spectrum, and hence enhanced detection resolution, then designed fabricated. Currently, limit sensor approximately 10−5...

We have synthesized a low-bandgap polymer, bithiazole-based polymer (PCPDTTBT) containing cyclopentadithiophene and thiophene units, studied its opticophysical properties morphologies in bulk heterojunction films after annealing. used confocal optical microscopy conjunction with fluorescence module to record exciton lifetime images within photoactive layers of PCPDTTBT [6,6]-phenyl-C61-butyric acid methyl ester (PCBM). These images, which were consistent those recorded using atomic force...