A5033633035- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Pneumonia and Respiratory Infections
- Pneumocystis jirovecii pneumonia detection and treatment
- Orthopedic Infections and Treatments
- Antifungal resistance and susceptibility
- Bacterial Identification and Susceptibility Testing
- Antibiotic Resistance in Bacteria
- Streptococcal Infections and Treatments
- Fungal Infections and Studies
- Hematological disorders and diagnostics
- Advancements in Photolithography Techniques
- Biosensors and Analytical Detection
- Sphingolipid Metabolism and Signaling
- Infectious Diseases and Tuberculosis
- Antibiotic Use and Resistance
- Glioma Diagnosis and Treatment
- Infectious Diseases and Mycology
- Total Knee Arthroplasty Outcomes
- Sepsis Diagnosis and Treatment
- Amoebic Infections and Treatments
- Advancements in Semiconductor Devices and Circuit Design
- Bacillus and Francisella bacterial research
- Respiratory and Cough-Related Research
- Bone fractures and treatments
LRS Institute of Tuberculosis and Respiratory Diseases
2014-2024
Institute of Child Health
2024
Laboratoire National de Référence
2024
Employees State Insurance Post Graduate Institute of Medical Sciences and Research
2024
Jawaharlal Nehru Cancer Hospital and Research Centre
2013-2022
IQVIA (India)
2020
University of Liverpool
2011-2018
Eaton (United Kingdom)
2014-2018
Alder Hey Children's Hospital
2011-2018
National Jewish Health
2016
Clinical prediction algorithms are used to differentiate transient synovitis from septic arthritis. These typically include the erythrocyte sedimentation rate (ESR), although in clinical practice measurement of C-reactive protein (CRP) has largely replaced ESR. We evaluated use CRP a predictive algorithm. The records 311 children with an effusion hip, which was confirmed on ultrasound, were reviewed (mean age 5.3 years (0.2 15.1)). Of these, 269 resolved without intervention and long-term...
The lipopolysaccharide (LPS) receptor complex consists of two interacting receptors (CD14 and TLR4) an associated protein (MD-2). When engaged by LPS, as in gram-negative infection, this transduces a signal detected MyD88 passed onward cascade the IRAKs, TRAF6, NIK, resulting activation NF-κB. A similar cascade, mediated TLR2, occurs with ligands derived from gram-positive bacteria. In vitro studies human monocytes have shown that TLR4 mRNA is paradoxically upregulated response to...
ABSTRACT Fluoroquinolones (FQs) are broad-spectrum antibiotics recommended for the treatment of multidrug-resistant tuberculosis (MDR-TB) patients. FQ resistance, caused by mutations in gyrA and gyrB genes Mycobacterium , is increasingly reported worldwide; however, information on occurring strains from Indian subcontinent scarce. Hence, this study, we aimed to characterize acid-fast bacillus (AFB) smear-positive sediments or M. isolates AFB smear-negative samples patients India suspected...
Purpose: There is scarcity of prevalence data multi-drug–resistant tuberculosis (MDR-TB) and common mutations responsible in North India. This study aimed to detect MDR-TB among suspects from Delhi mutation patterns using GenoType MTBDRplus assay. Materials Methods: All MDR five districts New were referred the laboratory 1st October 2011 31st December 2012 as per criterion defined by Programmatic Management Drug Resistant Tuberculosis (PMDT). assay was performed on 2182 samples or cultures...
Fluorescence microscopy (FM) over the years has shown potential for increasing performance of microscopy. The present study was aimed to access LED microscope detection acid fast bacilli in a tuberculosis (TB) endemic country.The conducted at National Reference Laboratory (NRL) New Delhi, India. Sputum samples were collected from suspected TB patients. Each sample processed with Auramine O and ZN methods. stained smears evaluated using two different excitatory light sources (MVP LED);...
The epidemiology of transient synovitis is poorly understood, and the aetiology unknown, although a suggestion viral association predominates.This population-based study investigated in order to formulate aetiological theories pathogenesis.Cases Merseyside were identified between 2004 2009. Incidence rates determined analysed by age, sex, season region residence. Socioeconomic deprivation scores generated using Index Multiple Deprivation, allocated postcode. Poisson confidence intervals...
Long-term mechanical ventilation in an Intensive Care Unit (ICU) exposes the patient to fungal colonization and invasive disease due presence of indwelling catheters, administration broad-spectrum antibiotics, intravenous corticosteroids. A study is hence required risk factors incidence infection these patients.A prospective observational was carried out respiratory ICU a tertiary care hospital for period approximately 1 year which patients on (>7 days) were enrolled. Blood, urine,...
There is limited information of level drug resistance to first-line and second line anti-tuberculosis agents in treatment naı ¨ve pulmonary tuberculosis (PTB) patients from the Indian region.Therefore, present prospective study was conducted determine antimicrobial susceptibility anti-TB such patients.Sputum samples consecutive PTB cases registered Lala Ram Sarup (LRS) district, under RNTCP containing 12 Directly Observed Treatment CentreÕs (DOTS), were enrolled
Data regarding prevalence of multi-drug resistant tuberculosis (MDR-TB) and associated common mutations is scarce from Punjab region. The study was designed to determine rate MDR-TB among presumptive mutation patterns using GenoType MTBDRplus assay. Total 812 consecutive sputum samples were received January 2012 July 2013, 14 districts at the National Reference Laboratory New Delhi for diagnosis as hand holding activity. Presumptive patients identified on basis criterion B defined by...
Background: Recently, moxifloxacin (MFX)-resistant results of Mycobacterium tuberculosis (Mtb) obtained by GenoType MTBDRsl (second-line line probe assay [SL-LPA]) have been stratified to determine their resistance level; however, its accuracy has not well studied. Therefore, the study aimed evaluate diagnostic SL-LPA, with phenotypic drug susceptibility testing (pDST) and whole-genome sequencing (WGS) for detection MFX-resistant Mtb level. Methods: A total 111 sputum samples were subjected...
The effect of non-rectilinear gate (NRG) due to sub-wavelength lithograph dramatically increases the leakage current by more than 15X. To mitigate this penalty, we have developed a systematic procedure optimize key layout parameters in regular with minimum area and speed overhead. As demonstrated 65 nm technology, optimization achieves 70% reduction under NRG, penalty ~10% marginal impact on circuit active power.
Cancellations on the day of surgery represent a major wastage resources and can impose significant distress patients. Minimising same cancellations improve cost effectiveness operating theatre running. The aim study was to determine impact administering questionnaire, by phone elective orthopaedic patients, week prior surgery. This questionnaire aimed at identifying factors that could lead cancellation for patient related reasons. administered patients over nine month period. rate due...