A5043235716- Endometrial and Cervical Cancer Treatments
- Phagocytosis and Immune Regulation
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Uterine Myomas and Treatments
- Ovarian cancer diagnosis and treatment
- PARP inhibition in cancer therapy
- Sarcoma Diagnosis and Treatment
- Cancer Research and Treatments
- Genetic factors in colorectal cancer
- Neuroblastoma Research and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Metastasis and carcinoma case studies
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer Mechanisms and Therapy
- Menopause: Health Impacts and Treatments
- Cancer Cells and Metastasis
- Cervical Cancer and HPV Research
- Global Cancer Incidence and Screening
- Cancer Immunotherapy and Biomarkers
- HER2/EGFR in Cancer Research
- Molecular Biology Techniques and Applications
- Radiation Dose and Imaging
- RNA modifications and cancer
- Clinical practice guidelines implementation
University of Alabama at Birmingham
2017-2025
O'Neal Comprehensive Cancer Center
2024
Barnes-Jewish Hospital
2020-2022
Washington University in St. Louis
2020-2022
Alvin J. Siteman Cancer Center
2021
University of Southern California
2011-2016
Saitama Medical University
2016
Saitama International Medical Center
2016
Los Angeles Medical Center
2016
October 6 University
2016
Abstract Purpose: The response to immune checkpoint inhibitors (ICI) in deficient mismatch repair (dMMR) colorectal cancer and endometrial is variable. Here, we explored the differential ICIs according different alterations Experimental Design: Colorectal (N = 13,701) 3,315) specimens were tested at Caris Life Sciences. Median overall survival (mOS) was estimated using Kaplan–Meier. prediction of high-, intermediate-, low-affinity epitopes by tumor mutation burden (TMB) values conducted...
Over 80% of women with high-grade serous ovarian cancer (HGSOC) develop tumor resistance to chemotherapy and die their disease. There are currently no FDA-approved agents improve sensitivity first-line platinum- taxane-based or PARP inhibitors. Here, we tested the hypothesis that expression growth arrest-specific 6 (GAS6), ligand receptor tyrosine kinase AXL, is associated response sequestration GAS6 AVB-S6-500 (AVB-500) could We found levels in patient serum samples collected before...
The treatment of metastatic and recurrent uterine leoimyosarcoma (uLMS) has evolved rapidly in the past several years. Leoimyosarcoma is extremely aggressive responds poorly to traditional chemotherapeutics. Recent regulatory approval novel options significantly expanded therapeutic armamentarium, addition these therapies challenged clinicians select optimally sequence new compounds. Additionally, potential role immunotherapy being assessed current uLMS clinical trials. Given increasing...
The aim of the study was to examine contributing factors associated with developing menopausal symptoms after surgical staging in women endometrial cancer.This is a retrospective examining patients cancer who were premenopausal at time hysterectomy-based including bilateral oophorectomy between January 2000 and October 2013. Cox proportional hazard regression model used evaluate demographics, medical comorbidity, liver function tests, tumor factors, medication history for symptoms.There 269...
Objective To determine how sociodemographic factors impact cervical cancer survival in different geographic locations the USA. Methods A retrospective cohort of patients with from January 1, 2004 to December 31, 2015 National Cancer Database (NCDB) was identified. Tumor characteristics as well race, income, insurance type, and treating facility types were compared among nine regions. χ 2 tests Cox regression used compare differences between regions; p values <0.05 considered significant....
BACKGROUND: Vulvar cancer has become more prevalent, and its causes include chronic dermatoses human papillomavirus (HPV)–mediated disease. Younger immunocompromised women can also be affected. We describe a case of vulvar carcinoma as result GATA2 deficiency. CASE: A 19-year-old woman presented to our gynecologic oncology clinic for management large mass. She was diagnosed with stage IB after vulvectomy. deficiency the contributing factor causing carcinoma. CONCLUSION: immunodeficiency in...
Endometrial cancer remains the most prevalent gynecologic with continued rising incidence. A less common form of this is uterine serous cancer, which represents 10% endometrial cases. However, aggressive cancer. The objective was to assess whether inhibiting receptor tyrosine kinase AXL AVB-500 in combination bevacizumab would improve response To prove this, we conducted multiple angiogenesis assays including tube formation and invasion assays. In addition, utilized mouse models cells lines...
•The first woman with a Malignant Brenner tumor and
The aim of this study was to determine preoperative risk factors associated with unplanned reoperation within 30 days for patients undergoing major surgery primary ovarian cancer using the National Surgical Quality Improvement Program database.We conducted a retrospective cohort utilizing database identify from 2012 2014. Patients who had their were identified. Demographics and clinical covariates calculated. Adjusted odds ratios (ORs) 95% confidence intervals (CIs) calculated univariate...
Twin pregnancies consisting of a complete hydatidiform mole and coexistent fetus (CMCF) are rare associated with high rate maternal-fetal morbidity mortality. Management these remains controversial increasingly challenging following the