A5088235649- Dendrimers and Hyperbranched Polymers
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Advanced Polymer Synthesis and Characterization
- Nanoparticle-Based Drug Delivery
- Collagen: Extraction and Characterization
- Polymer Surface Interaction Studies
- Gold and Silver Nanoparticles Synthesis and Applications
- Immunotherapy and Immune Responses
- Nanoplatforms for cancer theranostics
- Virus-based gene therapy research
- Synthesis and properties of polymers
- Chemical Synthesis and Analysis
- Silk-based biomaterials and applications
- Hydrogels: synthesis, properties, applications
- Bone Tissue Engineering Materials
- 3D Printing in Biomedical Research
- Supramolecular Self-Assembly in Materials
- Ear Surgery and Otitis Media
- Advanced Fluorescence Microscopy Techniques
- Lanthanide and Transition Metal Complexes
- DNA and Nucleic Acid Chemistry
- Optical Coherence Tomography Applications
- Advanced Drug Delivery Systems
- Marine and Coastal Research
Osaka Metropolitan University
2023-2025
Osaka Prefecture University
2015-2024
Tokyo Institute of Technology
2024
Chuo University
2022-2023
Graduate School USA
2015-2020
Setsunan University
2016
Weatherford College
2010
Osaka University
2004-2009
Kyoto University
2004-2009
Daicel (Japan)
2009
Polyamidoamine dendrimers having poly(ethylene glycol) grafts were designed as a novel drug carrier which possesses an interior for the encapsulation of drugs and biocompatible surface. Poly(ethylene monomethyl ether with average molecular weight 550 or 2000 was combined to essentially every chain end dendrimer third fourth generation via urethane bond. The glycol)-attached encapsulating anticancer drugs, adriamycin methotrexate, prepared by extraction chloroform from mixtures varying...
Gold nanoparticles (Au NPs) are a potential x-ray computed tomography (CT) contrast agent. A biocompatible and bioinactive surface is necessary for application of gold nanoparticle to CT imaging. Polyethylene glycol (PEG)-attached dendrimers have been used as drug carrier with long blood circulation. In this study, the Au NPs were grown in PEGylated dendrimer produce The by adding ions ascorbic acid at various equivalents NP-encapsulated solution. Both size plasmon absorption increased large...
Photodynamic therapy (PDT) is a noninvasive treatment of some diseases including cancer. We have developed poly(ethylene glycol) (PEG)-attached dendrimers as drug-carrier candidate. In this study, we prepared nanocapsules photosensitizers using PEG-attached for application to PDT. Two derived from poly(amido amine) (PAMAM) and poly(propylene imine) (PPI) (PEG−PAMAM PEG−PPI) were synthesized, rose bengal (RB) protoporphyrin IX (PpIX) used photosensitizers. Results showed that fewer PpIX...
Loading of HAuCl4 in poly(amido amine) G4 dendrimers having poly(ethylene glycol) (PEG) grafts at all chain ends and subsequent reduction with NaBH4 yielded PEG-modified encapsulating gold nanoparticles (Au NPs) ca. 2 nm diameter. The Au NPs held the were stable aqueous solutions dissolved readily, even after freeze-drying. Despite their small particle size, heat-generating ability dendrimer was comparable to that widely used 11 diameter under visible light irradiation. observed excellent...
A collagen model peptide-attached dendrimer was synthesized as a potential functional material. The peptides that clustered at the surface of formed thermally reversible collagen-like triple helix. This worked drug carrier with thermosensitive release capabilities, although it did not exhibit lower critical solution temperature. From this dendrimer, hydrogel could be made low
We have previously shown that modification with succinylated poly(glycidol) (SucPG) provides stable egg yolk phosphatidylcholine (EYPC) liposomes pH-sensitive fusogenic property. Toward production of efficient liposomes, in this study, we newly prepared three carboxylated derivatives varying hydrophobicities by reacting glutaric anhydride, 3-methylglutaric and 1,2-cyclohexanedicarboxylic respectively, designated as GluPG, MGluPG, CHexPG. Correlation between side-chain structures these...
The sensitive type: A lower critical solution temperature (LCST) is observed for dendrimers with N-isopropylamide (NIPAM) groups at all chain terminals and poly(N-isopropylacrylamide) (PNIPAAm; see picture). much smaller endothermic peak occurs around the LCST NIPAM-terminated dendrimers. globular structure of may cause inefficient hydration dehydration NIPAM below above LCST, respectively. Supporting information this article available on WWW under...
Hyperbranched poly(glycidol)s with varying degrees of polymerization were modified by reaction succinic anhydride and isopropylamine to obtain novel pH- thermosensitive polymers. These polymers exhibited phase transitions in response decreasing pH and/or increasing temperature, depending on the degree ratio succinyl group N-isopropylamide. It was possible harvest a bioactive molecule, rose bengal, from solution using transition hyperbranched poly(glycidol).
Dendrimers are potent nanocarriers in drug delivery systems because their structure can be precisely controlled. We previously reported that polyamidoamine (PAMAM) dendrimers were modified with 1,2-cyclohexanedicarboxylic acid (CHex) and phenylalanine (Phe), PAMAM-CHex-Phe, exhibited an effective association various immune cells, including T-cells. In this study, we synthesized carboxy-terminal Phe-modified different linkers using phthalic linear dicarboxylic acids to determine the of these...
Zwitterionic polymers exhibit strong hydration, high biocompatibility, and antifouling properties. Dendrimers are regularly branched polymers, which used in the drug delivery system (DDS). In this study, we synthesized zwitterionic monomer- polymer-conjugated dendrimers as a biocompatible nanoparticle to investigate relation between hydration property biodistribution. A sulfobetaine monomer (SBM) was conjugated at termini of polyamidoamine (PAMAM) dendrimer. Polysulfobetaines (PSBs) were...
Dendrimers are unique polymers with globular shapes and well-defined structures. We previously prepared poly(amidoamine) (PAMAM) dendrimers having phenylalanine (Phe) residues at every chain end of the dendrimer as efficient gene carriers. In this study, we found that Phe-derivatized PAMAM change their water solubility depending on temperature. The were soluble in aqueous solutions low temperatures, but they became water-insoluble temperatures above a specific threshold, which is termed...
ADVERTISEMENT RETURN TO ISSUEPREVNoteControl of Temperature-Sensitive Properties Poly(amidoamine) Dendrimers Using Peripheral Modification with Various Alkylamide GroupsYasuhiro Haba, Chie Kojima, Atsushi Harada, and Kenji KonoView Author Information Department Applied Chemistry, Graduate School Engineering, Osaka Prefecture University, 1-1 Gakuen-cho, Nakaku, Sakai, 599-8531, Japan Cite this: Macromolecules 2006, 39, 21, 7451–7453Publication Date (Web):September 7, 2006Publication History...
ADP-ribosylation factor (Arf) 6 activity is crucially involved in the regulation of E-cadherin-based cell-cell adhesions. Erythropoietin-producing hepatocellular carcinoma (Eph)-family receptors recognize ligands, namely, ephrins, anchored to membrane apposing cells, and they mediate contact-dependent events. Here, we found that Arf6 down-regulated Madin-Darby canine kidney which dependent on cell density calcium ion concentration, provide evidence a novel signaling pathway by...