A5036867631- Immune Cell Function and Interaction
- Immune cells in cancer
- Gut microbiota and health
- Immune Response and Inflammation
- Gastrointestinal motility and disorders
- T-cell and B-cell Immunology
- Escherichia coli research studies
- Pneumonia and Respiratory Infections
- Cancer Cells and Metastasis
- Diabetes and associated disorders
- Bacterial Infections and Vaccines
- Pancreatic and Hepatic Oncology Research
- Microscopic Colitis
University of Münster
2025
Universitätsklinikum Erlangen
2019-2024
Friedrich-Alexander-Universität Erlangen-Nürnberg
2019
Excessive macrophage (Mφ) activation results in chronic inflammatory responses or autoimmune diseases. Therefore, identification of novel immune checkpoints on Mφ, which contribute to resolution inflammation, is crucial for the development new therapeutic agents. Herein, we identify CD83 as a marker IL-4 stimulated pro-resolving alternatively activated Mφ (AAM). Using conditional KO mouse (cKO), show that important phenotype and function Mφ. CD83-deletion decreased levels inhibitory...
Type 1 diabetes (T1D) is a chronic multi-factorial disorder characterized by the immune-mediated destruction of insulin-producing pancreatic beta cells. Variations at large number genes influence susceptibility to spontaneous autoimmune T1D in non-obese diabetic (NOD) mice, one most frequently studied animal models for human disease. The genetic analysis these mice allowed identification many insulin-dependent (Idd) loci and candidate genes, them being Cd101. CD101 heavily glycosylated...
Intestinal microbiota signal to local and distant tissues in the body. Thus, they also regulate biochemical, metabolic immunological processes gut pancreas. Vice versa, eating habits or immune system of host shape intraluminal microbiota. Disruptions these versatile host-microbiota interactions underlie pathogenesis complex immune-mediated disorders such as inflammatory bowel disease (IBD) type 1 diabetes (T1D). Consequently, dysbiosis increased intestinal permeability associated with both...