A5089239434- Immune Cell Function and Interaction
- Wnt/β-catenin signaling in development and cancer
- Congenital heart defects research
- Diabetes and associated disorders
- Epigenetics and DNA Methylation
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Pluripotent Stem Cells Research
- Hippo pathway signaling and YAP/TAZ
- Developmental Biology and Gene Regulation
- Pancreatic function and diabetes
- Cancer-related gene regulation
- Kruppel-like factors research
- Immunotherapy and Immune Responses
- Genetic Syndromes and Imprinting
- Nuclear Receptors and Signaling
Cincinnati Children's Hospital Medical Center
2004-2019
Diabetes Research Center
2010
Center of Molecular Immunology (Cuba)
2010
University of Cincinnati
2004-2007
The canonical Wnt pathway is necessary for gut epithelial cell proliferation, and aberrant activation of this causes intestinal neoplasia. We report a novel mechanism by which the Sox family transcription factors regulate signaling pathway. found that some proteins antagonize while others enhance β-catenin/T-cell factor (TCF) activity. Sox17, expressed in normal epithelium but exhibits reduced expression neoplasia, antagonistic to signaling. When overexpressed SW480 colon carcinoma cells,...
Little is known about how the endoderm germ layer patterned along anterior-posterior (A-P) axis before formation of a gut tube (embryonic day [e] 7.5-8.5 in mouse), largely due to paucity molecular markers endoderm. In particular, there are few genes that mark posterior domains give rise midgut and hindgut. We have identified 8 expressed discrete gastrula stage (e7.5), suggesting significant level pattern exists tube. Three Tmprss2, NM_029639, Dsp presumptive domain overlying node, for which...
Abstract In type 1 diabetes, the breach of central and peripheral tolerance results in autoreactive T cells that destroy insulin-producing, pancreatic β cells. this study, we identify a critical subpopulation dendritic responsible for mediating both cross-presentation islet Ags to CD8+ direct presentation cell CD4+ These cells, termed merocytic (mcDCs), are more numerous NOD mouse and, when Ag-loaded, rescue from anergy deletion while stimulating islet-reactive When purified lymph nodes...
Type 1 diabetes (T1D) is a chronic multi-factorial disorder characterized by the immune-mediated destruction of insulin-producing pancreatic beta cells. Variations at large number genes influence susceptibility to spontaneous autoimmune T1D in non-obese diabetic (NOD) mice, one most frequently studied animal models for human disease. The genetic analysis these mice allowed identification many insulin-dependent (Idd) loci and candidate genes, them being Cd101. CD101 heavily glycosylated...
TCR ligation is critical for the selection, activation, and integrin expression of T lymphocytes. Here, we explored role adaptor protein slp-76 on iNKT-cell biology. Compared to B6 controls, slp-76(ace/ace) mice carrying a missense mutation (Thr428Ile) within SH2-domain showed an increase in iNKT cells thymus lymph nodes, but decrease spleens livers, along with reduced ADAP cytokine response. A comparable reduction was observed livers ADAP-deficient mice. Like ADAP(-/-) cells, were...