A5017435449- Venous Thromboembolism Diagnosis and Management
- Complement system in diseases
- Blood properties and coagulation
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Renal Diseases and Glomerulopathies
Hospital Israelita Albert Einstein
2016-2019
Rivaroxaban is an oral direct factor Xa inhibitor, therapeutically indicated in the treatment of thromboembolic diseases. As other new anticoagulants, routine monitoring rivaroxaban not necessary, but important some clinical circumstances. In our study a high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was validated to measure plasmatic concentration. Our used simple sample preparation, protein precipitation, and fast chromatographic run. It developed...
To discuss the implementation of technical advances in laboratory diagnosis and monitoring paroxysmal nocturnal hemoglobinuria for validation high-sensitivity flow cytometry protocols.A retrospective study based on analysis data from 745 patient samples submitted to and/or hemoglobinuria.Implementation reduced test costs improved resolution clone detection.High-sensitivity allowed more sensitive determination type size, particularly with small clones.Discutir as melhorias técnicas no...
The aim of the study was to evaluate diagnostic accuracy thromboelastometry for assessing rivaroxaban concentrations. compared with high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) method, which is gold standard drug plasma monitoring (the reference standard). Forty-six clinically stable patients were treated 10, 15, or 20 mg once daily (OD group) 15 twice a day (BID (no particular indication treatment). Patient samples collected 2 h after use medication (peak)...