A5066523414- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Electrospun Nanofibers in Biomedical Applications
- Cardiac and Coronary Surgery Techniques
- Peripheral Artery Disease Management
- Cell Adhesion Molecules Research
- Venous Thromboembolism Diagnosis and Management
- Protease and Inhibitor Mechanisms
- Diagnosis and Treatment of Venous Diseases
- Angiogenesis and VEGF in Cancer
- Connective tissue disorders research
- Pressure Ulcer Prevention and Management
- Cardiac Valve Diseases and Treatments
- Wound Healing and Treatments
- Tissue Engineering and Regenerative Medicine
- 3D Printing in Biomedical Research
- Intracranial Aneurysms: Treatment and Complications
- Microbial metabolism and enzyme function
- Bone Tissue Engineering Materials
- Health and Medical Research Impacts
- Cellular Mechanics and Interactions
- Diabetic Foot Ulcer Assessment and Management
- Acute Ischemic Stroke Management
- Cardiac, Anesthesia and Surgical Outcomes
- Lymphatic System and Diseases
University of Maryland, Baltimore
2017-2024
Baltimore VA Medical Center
2020-2024
VA Maryland Health Care System
2023-2024
Center for Vascular Biology Research
2022
Veterans Health Administration
2019-2022
University of Maryland Medical Center
2019
Loyola University Chicago
2011-2017
University of Chicago
2011-2017
Loyola University Medical Center
2007-2013
Tufts University
2007
In the BEST-CLI trial (Best Endovascular Versus Best Surgical Therapy for Patients With Chronic Limb-Threatening Ischemia), a prespecified secondary objective was to assess effects of revascularization strategy on health-related quality life (HRQoL).
ObjectiveChronic venous leg ulcers (VLUs) affect up to 2% of the general population, resulting in a significant socioeconomic burden. Placental tissue that contains mesenchymal stem cells and active growth factors has been shown be beneficial healing chronic wounds. We compared efficacy human viable wound matrix (hVWM) cryopreserved placental for treatment refractory VLUs with standard therapy.MethodsThis prospective single-center open-label single-arm study enrolled patients Clinical,...
Moderate aerobic exercise was shown to significantly reduce mortality, extracellular matrix degradation, and thoracic aortic aneurysm dissection formation associated with lysyl oxidase inhibition in a mouse model. Gene expression suggested reversal of TGF-β, inflammation, remodeling pathway dysregulation, along augmented elastogenesis exercise.
The delivery of growth factors to cellularize biocompatible scaffolds like fibrin is a commonly used strategy in tissue engineering. We characterized smooth muscle cells (SMC) proliferation and chemotaxis response PDGF-BB FGF-2, alone combination, 2D culture 3D hydrogels. While both induced an equipotent mitogenic culture, only FGF-2 was significantly for SMCs culture. Only chemotactic modified Boyden chamber assay. In assay matrix invasion, invasive into the hydrogel proliferating...
Obtaining an NIH career development award ("K award") is often important step in establishing a as vascular surgeon scientist. The application and review process competitive, involves many steps, may be confusing to the prospective applicant. Further, there are requirements involving mentors applicant's institution. This article, authored completely by surgeons with active K awards, intended for potential applicants personnel at their institution reviews relevant information including...
While much about the fundamental mechanisms behind initiation and progression of Type B aortic dissection (TBAD) is still unknown, predictive models based on patient-specific fluid-structure interaction (FSI) simulations can help in risk stratification optimal clinical decision-making. Aiming at development personalized treatment, FSI be leveraged to investigate interplay between complex flow patterns anatomical features, while considering deformation arterial wall flap. In this study,...
The development of a functional microvasculature is critical to the long-term survival implanted tissue-engineered constructs. Dynamic culture conditions have been shown significantly modulate phenotypic characteristics and stimulate proliferation cells within hydrogel-based tissue engineered blood vessels. Although prior work has described effects uniaxial or equibiaxial mechanical stimulation on endothelial cells, no outlined three-dimensional tubular vessel analogues. We demonstrate here...
Pathological vascular smooth muscle cell (VSMC) behavior after interventions such as angioplasty or bypass is initiated within the 3D environment of vessel media. Here VSMCs proliferate, invade surrounding matrix, migrate adluminally, and deposit substantial amounts leading to myointimal hyperplasia decreased blood flow critical organs tissue. Since focal adhesion kinase (FAK) mediates many VSMC responses these pathologic events, it provides a reasonable pharmacologic target limit this...
Large vessel arterial thrombosis has been reported to complicate a subset of cases coronavirus disease 2019 (COVID-19). Thrombosis the extracranial carotid system can lead devastating stroke in some patients with COVID-19. We have presented case patient previously hospitalized COVID-19 for oxygen supplementation who had after discharge delayed from right common artery and internal thrombosis. The thrombotic occlusion resolved antithrombotic medications no invasive intervention. present...
Vascular smooth muscle cells (vSMCs) exert a critical role in sensing and maintaining vascular integrity. These abundantly express the low-density lipoprotein receptor-related protein 1 (LRP1), large endocytic signaling receptor that recognizes numerous ligands, including apolipoprotein E-rich lipoproteins, proteases, protease-inhibitor complexes. We observed spontaneous formation of aneurysms superior mesenteric artery (SMA) both male female mice which LRP1 was genetically deleted vSMCs...
Aortic aneurysm and dissection is associated with significant morbidity mortality in the population can be highly lethal. While animal models of aortic disease exist, vivo imaging vasculature has been limited. In recent years, micro-computerized tomography (micro-CT) emerged as a preferred modality for both large small vessels ex vivo. conjunction method vascular casting, we have successfully used micro-CT to characterize frequency distribution pathology β-aminopropionitrile-treated C57/Bl6...
IntroductionVarious adjunct therapies are available for wound healing in addition to standard care. Topical oxygen therapy (TCOT) is one such novel therapy. We conducted a systematic review and meta-analysis evaluate the role of TCOT cutaneous wounds any etiology.MethodsThe was on articles related treated with identified through PubMed, MEDLINE/OVID, Cochrane, Google Scholar. included randomized controlled trials, double-arm prospective studies, single-arm case-control series, case reports...
Objective: Acute limb ischemia (ALI) due to thromboembolism is a limb- and life-threatening condition regularly encountered by vascular surgeons. Iatrogenic distal embolization occasionally seen as complication of various endovascular procedures. We present series four patients who developed ALI arterial during cardiovascular procedures that were successfully treated via catheter directed aspiration embolectomy. Methods: Retrospective review demographics, risk factors, procedural outcomes...
Obtaining an NIH career development award ("K award") is often important step in establishing a as vascular surgeon scientist. The application and review process competitive, involves many steps, may be confusing to the prospective applicant. Further, there are requirements involving mentors applicant's institution. This article, authored completely by surgeons with active K awards, intended for potential applicants personnel at their institution reviews relevant information including...
While much about the fundamental mechanisms behind initiation and progression of Type B aortic dissection (TBAD) is still unknown, predictive models based on patient-specific computational fluid dynamics (CFD) can help in risk stratification optimal clinical decision-making. Aiming at development personalized treatment, CFD simulations be leveraged to investigate interplay between complex flow patterns anatomical features. In this study, hemodynamics false lumen thrombosis, a large...