A5045114609- Phytochemistry Medicinal Plant Applications
- Osteoarthritis Treatment and Mechanisms
- Bee Products Chemical Analysis
- Inflammatory mediators and NSAID effects
- Essential Oils and Antimicrobial Activity
- Pain Mechanisms and Treatments
- Pomegranate: compositions and health benefits
- Agricultural and Food Sciences
- Natural product bioactivities and synthesis
- Insect and Pesticide Research
- Healthcare Regulation
- Iron Metabolism and Disorders
- Computational Drug Discovery Methods
- Natural Antidiabetic Agents Studies
- Hemoglobinopathies and Related Disorders
- Medicinal Plants and Neuroprotection
- Dermatologic Treatments and Research
- Rheumatoid Arthritis Research and Therapies
- Phytochemistry and Biological Activities
- Bioactive Compounds and Antitumor Agents
- Veterinary Pharmacology and Anesthesia
- Bone Metabolism and Diseases
- Health, Education, and Aging
- Workaholism, burnout, and well-being
- Phytochemistry and Bioactivity Studies
Universidade Federal do Maranhão
2011-2025
Mundipharma (Germany)
2023
Wista (Czechia)
2023
Candida albicans is a human pathogen that part of the healthy microbiome. However, it often associated with opportunistic fungal infections. The treatment these infections challenging because prolonged exposure to antifungal drugs can culminate in resistance during therapy, and there limited number available drugs. Therefore, this study investigated activity ononin by silico vitro assays, Tenebrio molitor as an alternative vivo model infection caused C. albicans. Ononin isoflavone glycoside...
The aim of this study was to analyze the analgesic potential Arrabidaea chica extract (EHA) as an alternative osteoarthritis (OA) treatment. Thus, initially evaluated by cyclooxygenase inhibition test. effect extract, in vivo, also verified a model OA induced sodium monoiodoacetate (2 mg). EHA administered rats at doses 50, 150, and 450 mg/kg between 3 25 days after induction. animals were clinically every 7 days, euthanized 29 liver, spleen, kidney knee collected for histopathological...
Bees are of great importance for plant diversity being an important pollinating agents. Stingless bees such as Scaptotrigona affinis postica, is cultivated largely due to the products offered by it. Pollen one these products, which has been highlighted exhibit various therapeutic properties. Considering bioactivity this natural product, study investigated antioxidant, anti-inflammatory, antinociceptive activities, and elucidated chemical composition pollen collected extract postica. Using in...
Introdução: A tendinite do calcâneo é cada vez mais encontrada em diversas populações, destaque nos atletas e pessoas sedentárias. Sendo recorrente a busca por tratamento para essa condição, tem sido alvo de várias prospeções cientificas. fotobiomodulação laser (PBM), utilizada nestes casos seu potencial anti-inflamatório ter premissa auxiliar no reparo tecidual. Objetivo: Analisar literatura acadêmica considerando as publicações indexadas sobre os efeitos da PBM ratos. Métodos: Trata-se uma...
A cistite intersticial/síndrome da bexiga dolorosa (CI/SBD) é uma condição crônica de etiologia desconhecida, caracterizada por dor pélvica e sintomas urinários irritativos. O diagnóstico desafiador, geralmente realizado exclusão outras condições utilização exames invasivos. Nesse contexto, os microRNAs (miRNAs) surgem como potenciais biomarcadores diagnósticos alvos terapêuticos promissores. revisão utilizou bases dados científicas (PubMed, Web of Science, Scopus SciELO) para identificar...
The stingless bee, Melipona fasciculata Smith (Apidae, Meliponini), is a native species from Brazil. Their products have high biotechnological potential, however there are no studies about the biological activities of pollen collected by M. fasciculata. In this context, present study investigated chemical composition, anti-oxidant, anti-inflammatory, and analgesic hydroethanolic extracts in three cities Maranhão State, We verified antioxidant activity inhibitory against cyclooxygenase enzyme...
This study evaluated the in vivo potential antihypertensive effect of hydroalcoholic extract Syzygium cumini leaves (HESC) normotensive Wistar rats and spontaneously hypertensive (SHR), as well its vitro on vascular reactivity resistance arteries. The hypotensive caused by intravenous infusion HESC (0.01-4.0 mg/kg) anesthetized was dose-dependent partially inhibited pretreatment with atropine sulfate. SHR received (0.5 g/kg/day), orally, for 8 weeks mean arterial pressure, heart rate, were...
Introduction: Strontium ranelate (SrRan) has the potential to interfere in progression of osteoarthritis (OA), multifactorial disease associated with mechanical problems and articular inflammatory changes. Objectives: This study aimed test effects prophylactic therapeutic use SrRan on clinical parameters pain, process, degradation cartilage. Methods: was an experimental study, using a model knee OA induced by intra-articular injection monoiodoacetate. Thirty Wistar rats were divided into...
Geopropolis is produced by some stingless bee species, such as Melipona fasciculata Smith, a native species from Brazil. This study aims to investigate the antioxidant and anti-inflammatory activities cytotoxicity effects of geopropolis hydroethanolic extracts against lung (H460 A549) ovarian (A2780 ES2) cancer cell lines non-tumor (HUVEC) using chemical identification LC/MS/MS analysis in silico assays determine which compounds are associated with bioactivity. The activity inhibitory COX...
Pharmacological treatment of osteoarthritis is still inadequate due to the low efficacy drugs used. Dexmedetomidine via intra-articular (i.a.) route might be an option for osteoarthritis-associated pain. The present study assessed analgesic and anti-inflammatory effects dexmedetomidine administered i.a. in different doses experimental model rat knee induced with monosodium iodoacetate. Rats were allocated four groups 24 animals each group. OA (osteoarthritis), DEX-1 (dexmedetomidine dose...
Osteoarthritis (OA) is a chronic degenerative disease that has significant global impact. It associated with aging and characterized by widespread joint destruction. Cuminaldehyde biologically active component of essential oils shown promise in the treatment nociceptive inflammatory diseases. This study investigated effects cuminaldehyde on an experimental model osteoarthritis induced rat knees. was found to be as effective indomethacin reducing pain all evaluated tests, including forced...
Pain is recognized as one of the main symptoms in knee osteoarthritis and reason why patients seek medical attention. Scoparia dulcis has been popularly used to relieve discomfort caused by various painful conditions. The objective study evaluate analgesic anti-inflammatory effect crude extract S. dulcis, an experimental model osteoarthritis. experiment was performed with Wistar rats divided into 4 groups 5 animals each: healthy, saline, extract, meloxicam groups. Knee induced...
Mycobacterium abscessus subsp. massiliense (Mabs) causes chronic infections, which has led to the need for new antimycobacterial agents. In this study, we investigated and anti-inflammatory activities of ethyl acetate fraction Bixa orellana leaves (BoEA) ellagic acid (ElAc). silico analysis predicted that ElAc had low toxicity, was not mutagenic or carcinogenic, antimicrobial activities. Apparently, can interact with COX2 Dihydrofolate reductase (DHFR) enzymes, could explain both vitro...
The perception of prejudice against, and stigmatization of, sickle cell disease (SCD) leads the patient to perceive a different treatment, due stigma may be related worse quality life (QoL).Describe evaluate against its impact on patients with disease.This is cross-sectional study conducted between March 2019 February 2020, diagnosed SCD. Patients were questioned about in any kind situation, choosing "Yes" or "No", not differentiating situations prejudice. To assess QoL disease, volunteers...
Este estudo buscou investigar a aplicabilidade da talidomida no manejo dor na endometriose induzida em animais. Foi realizada uma revisão de escopo confeccionada e organizada seguindo o método Joanna Briggs Institute, além seguir os padrões do PRISMA – ScR. Foram feitas pesquisas seis bases dados eletrônicas associando descritores as palavras chaves, por meio busca booleana correspondente aos blocos conceituais voltados para recuperação estudos sobre endometriose, dor, talidomida. Os países...
This study aimed to investigate the analgesic impact of S(+)-ketamine on pain behavior and synovial inflammation in an osteoarthritis (OA) model.
Osteoarthritis (OA) remains a chronic incurable condition, presenting substantial challenges in treatment. This study explores novel strategy by investigating the concurrent use of cuminaldehyde, natural compound, with indomethacin animal models MIA-induced OA. Our results demonstrate that co-administration cuminaldehyde and does indeed produce superior effect when compared to these compounds individually, significantly enhancing therapeutic outcomes. is evidenced marked reduction...
A dor neuropatica (DN) e causada por uma lesao ou doenca do sistema nervoso somatossensorial, que acomete cerca de 8% da populacao mundial, sendo seu manejo considerado um grande desafio, devido a sua complexidade ausencia de medicacao especifica. Na busca novas terapias para DN, surge neste cenario a especie vegetal Arrabidaea chica Verlot, conhecida popularmente carajiru e pariri, cujas propriedades anti-inflamatorias sao cientificamente comprovadas. O objetivo deste estudo foi...