A5051931535- Extracellular vesicles in disease
- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Neonatal Respiratory Health Research
- Otolaryngology and Infectious Diseases
- Appendicitis Diagnosis and Management
- Streptococcal Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- MicroRNA in disease regulation
- Respiratory Support and Mechanisms
- Intraperitoneal and Appendiceal Malignancies
- Cardiac Arrest and Resuscitation
- Emergency and Acute Care Studies
- Trauma and Emergency Care Studies
- Hemodynamic Monitoring and Therapy
- Circular RNAs in diseases
- Hernia repair and management
- Healthcare cost, quality, practices
- Cardiac, Anesthesia and Surgical Outcomes
- Burn Injury Management and Outcomes
- Renal function and acid-base balance
- Pneumocystis jirovecii pneumonia detection and treatment
- Pulmonary Hypertension Research and Treatments
- Healthcare Decision-Making and Restraints
- Intestinal and Peritoneal Adhesions
The Ohio State University Wexner Medical Center
2012-2024
The Ohio State University
2013-2024
Collaborative Group (United States)
2023
Lung Institute
2013
University of Cincinnati Medical Center
2007
ABSTRACT Extracellular vesicles (EVs) are mRNA‐containing cell fragments shed into circulation during pathophysiological events. DNA methyltransferases (DNMT1, DNMT3A, and DNMT3B) regulate gene expression by modifying methylation altering transcription. Sepsis is a systemic insult resulting in vascular dysfunction, which can lead to shock death. We analysed plasma from ICU patients for circulating EV numbers, defined as particles isolated 1 mL at 21,000x g , DNMTs mRNA content prognostic...
Background: Patients with sepsis exhibit significant long-term immunosuppressive sequelae. Monocyte dysfunction is a hallmark of this damage. Circulating exosomes are an important mediator the systemic signaling events that occur during septic response; thus, we sought to characterize contribution circulating inflammatory process induced Methods: Monocyte-derived were isolated from cultured monocytes healthy adult donors via stimulation lipopolysaccharide (LPS) or phosphate-buffered saline...
A significant proportion of patients with burn injury have diabetes. Although hyperglycemia during critical illness has been associated poor outcomes, chronic based on elevated hemoglobin A1c (HbA1c) measurements at admission shown to tolerate higher glucose levels hospitalization. This relationship not evaluated in the population. The objective this study was examine impact control outcomes acute period after burn. is a retrospective analysis comparing (HbA1c ≥6.5%) and euglycemia <6.5%)....
Abstract Aims/Introduction Genetic and epigenetic mechanisms have been implicated in the pathogenesis of type 1 diabetes, histone acetylation is an modification pattern that activates gene transcription. However, genome‐wide H3 new‐onset diabetes patients has not well described. Accordingly, we aimed to unveil promoter profile CD 4 + T lymphocytes from patients, especially for those who are glutamate decarboxylase antibody‐positive. Materials Methods A total 12 with were antibody‐positive...
Emerging data support the pivotal role of extracellular vesicles (EVs) in normal cellular physiology and disease conditions. However, despite their abundance, there is much less information about lipid mediators carried EVs, especially context acute lung injury (ALI). Our demonstrate that C57BL/6 mice subjected to intranasal <i>Escherichia coli</i> lipopolysaccharide (LPS)-induced ALI release, a higher number EVs into alveolar space, compared saline-treated controls. released...
BACKGROUND While obesity is a risk factor for postoperative complications, its impact following sepsis unclear. The primary objective of this study was to evaluate the association between and mortality admission surgical intensive care unit (SICU) with sepsis. METHODS We conducted single center retrospective review SICU patients grouped into obese (n = 766, body mass index ≥30 kg/m 2 ) nonobese 574; index, 18–29.9 cohorts. Applying 1:1 propensity matching age, sex, comorbidities, sequential...
Recent review of older (≥45-years-old) patients admitted to our trauma center showed that more than one-third were using neuro-psychiatric medications (NPMs) prior their injury-related admission. Previously published data suggests use NPMs may increase patients' risk and severity injury. We sought examine the impact pre-injury NPM on morbidity mortality.Retrospective record included medication regimen characteristics (antidepressants-AD, antipsychotics-AP, anxiolytics-AA). Hospital...
Background: The impact of obesity on the pathogenesis and prognosis necrotizing soft tissue infections (NSTIs) is unclear. goal this study was to characterize differences in NSTI presentation outcomes by status. Patients Methods: A retrospective analysis institutional data for patients diagnosed with NSTIs were identified (n = 619; 2011-2020). divided based (body mass index [BMI] ≥ 30 kg/m2) non-obese (BMI <30 kg/m2). Primary included location, micro-organisms, hospitalization data. Multiple...
The authors report two cases of patients presenting with chemical frostbite-like injuries to the hands and wrists after contact exposure Freon liquid. Although history initial physical presentations were quite similar, severity these varied widely from superficial bullae deep tissue injuries, requiring skin grafting amputation several digits. is a used coolant in refrigerators, air conditioners, freezers, water coolers, boiling point −41°C. Freon-induced inhalational injury have been...
Background: The impact of socioeconomic status on outcomes after sepsis has been challenging to define, and no polysocial metric shown predict mortality in sepsis. primary objective this study was evaluate the association between Area Deprivation Index (ADI) patients admitted surgical intensive care unit (SICU) with Patients Methods: All SICU (Sequential Organ Failure Assessment [SOFA] score ≥2) were retrospectively reviewed. ADI scores obtained classified as “high ADI” (≥85th percentile, n...
Rapid shallow breathing index (RSBI, respiratory frequency [f] divided by tidal volume [Vt]) has been used to prognosticate liberation from mechanical ventilation (LMV). We hypothesize that dynamic changes in RSBI predict failed LMV better than isolated measurements. conducted a retrospective study of patients who were mechanically ventilated (MV) for longer 72 hours. Failed was defined as need reinstitution MV within 48 hours post-LMV. Ventilatory (f) and Vt (liters) serially recorded. The...
Background: Necrotizing soft tissue infections (NSTIs) are severe, rapidly spreading with high morbidity and mortality. Attempts to identify risk factors for mortality have produced variable results. We hope determine which across the NSTI population impact mortality, morbidities, discharge disposition. Patients Methods: Retrospective data from National Inpatient Sample 2012-2018 of patients primary diagnosis (gas gangrene, necrotizing faciitis, cutaneous or Fournier gangrene) were...
Abstract Background Initiation of parenteral nutrition (PN) after a period starvation can be complicated by refeeding syndrome (RFS). RFS is associated with electrolyte abnormalities including hypomagnesemia, hyponatremia, and hypophosphatemia. Risk factors include recent weight loss, low body mass index, deficiencies; however, these associations are not strong. We hypothesized that validated measure risk, computed tomography (CT)–measured psoas muscle density, used to predict the...
Background: Necrotizing soft tissue infections (NSTIs) are life-threatening requiring prompt intervention. The Distressed Communities Index (DCI) is a comprehensive ranking of socioeconomic well-being based on zip code. We sought to identify the role DCI in predicting mortality NSTI, because it remains unknown. Patients and Methods: A retrospective, single-institution analysis patients diagnosed with NSTI (2011-2020) surgical composite score community-level factors: unemployment, education...