A5044353287- Reconstructive Facial Surgery Techniques
- Lymphatic System and Diseases
- Cutaneous Melanoma Detection and Management
- Reconstructive Surgery and Microvascular Techniques
- Vascular Malformations and Hemangiomas
- Tumors and Oncological Cases
- Wound Healing and Treatments
- Nonmelanoma Skin Cancer Studies
- Dermatologic Treatments and Research
- Cleft Lip and Palate Research
- Craniofacial Disorders and Treatments
- Ear and Head Tumors
- Diagnosis and Treatment of Venous Diseases
- Facial Nerve Paralysis Treatment and Research
- Ear Surgery and Otitis Media
- Cancer and Skin Lesions
- Burn Injury Management and Outcomes
- Angiogenesis and VEGF in Cancer
- Surgical site infection prevention
- Sympathectomy and Hyperhidrosis Treatments
- Nasal Surgery and Airway Studies
- Tracheal and airway disorders
- Facial Rejuvenation and Surgery Techniques
- Body Contouring and Surgery
- Ocular Disorders and Treatments
Hokkaido University
2016-2025
Hokkaido University Hospital
2007-2023
Creative Commons
2023
Sapporo University
2011-2017
Tonan Hospital
2011-2015
Hokkaido Sapporo Kita High School
2011
Tokyo-Kita Medical Center
2011
Hakodate Central General Hospital
2003
University of Arizona
2001
University of the West
2001
Published reports indicate that corticosteroid injections can prevent recurrence after keloid excision, but the side effects of repetitive intralesional steroid may preclude treatment maintenance. Additionally, few these studies employed a standardized protocol.To analyze results new uniform protocol combining and ointment application designed to reduce rates excisional surgery in individuals with keloids or hypertrophic scars.As standard procedure, first injection took place removal sutures...
Objective: Drugs regulating hypoxia-inducible factor (HIF)-1α have not been investigated for wound healing in lymphedema. Therefore, we examined the effects of drug modulation HIF-1α activity our previously developed mouse model nonirradiated hind limb Approach: Mouse lymphedema models (n = 17) and a sham group 6) were created using 8- to 10-week-old male C57BL/6N mice. Mice with randomized into experimental groups receiving roxadustat, 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole (YC-1),...
Microsurgical lymphaticovenous implantation in lymphedema is done to create a shunt by an of collecting lymphatics into the small vein, as reported previously. The authors have recently introduced ultrasonograpy and indocyanine green fluorescence lymphography this procedure.Nine cases postmastectomy had received preoperative venous marking using ultrasonography lymphatic mapping lymphography. concept modification pick up most effective point for microsurgical that involves both subcutaneous...
Keloid is an inflammatory and fibrotic disease with unknown pathogenesis. Regulatory T cells (Tregs) of CD4+ lineage can suppress other effector modulate the immune response. A relative decrease in number Tregs may be involved pathogenesis diseases. We therefore investigated keloids using immunohistochemistry examined interaction between keloid fibroblasts (KFs) a coculture system. It was found that ratio Tregs/CD4+ lower compared common skin conditions. In addition, Treg-enriched reduced...
To compare dental arch relationship outcomes following one- and two-stage palatal repair.Nonrandomized, clinical trial with concurrent control.Hokkaido University Hospital.Sixty-eight consecutively treated Japanese patients complete unilateral cleft lip palate.Thirty-one of the 68 underwent palatoplasty delayed hard palate closure, 37 one-stage pushback palatoplasty.Dental casts were taken at 4.9 to 6.3 (mean: 5.2) years age in group 4.0 5.1) group, relationships assessed using 5-Year-Olds'...
Lymphedema is known to be caused by many pathologic conditions; however, its correct diagnosis and optimal therapeutic strategies remain established. In this report, we describe an experimental model for acquired lymphedema in the lower extremity of mouse that creates a lymphatic block groin induced both radiation treatment surgical division superficial deep lymphatics. To evaluate system model, indocyanine green fluorescence-sensitive camera was used. This has advantages relative technical...
The triple technique (lymphoscintigraphy, patent-blue staining, and a gamma probe) constitutes reliable method for the sentinel lymph node (SLN) biopsy. However, in head neck melanomas, shine-through phenomenon, which occurs because these SLNs are close to primary focus, is irreversibly problematic. To get around this study uses fluorescence navigation with indocyanine green (ICG) as well technique.ICG dye can be used marker infrared fluorescence. ICG solution intradermally injected tumor....
Background: Mesenchymal stem cells are a valuable cell source in regenerative medicine, and conditioned medium obtained from mesenchymal reportedly inhibits inflammation. Keloids characterized by abnormal fibrosis, caused fibroblasts response to In this study, the authors evaluated whether amnion-derived suppressed activation of keloid fibroblasts. Methods: Keloid ( n = 7), mature 5), normal 5) were harvested patients. Fibroblasts stimulated with transforming growth factor (TGF)-β, effects...
Background: The pathophysiology of secondary lymphedema remains poorly understood. This study aimed to establish a consistent mouse hindlimb model for further investigation the mechanism and treatment lymphedema. Methods: authors developed novel postsurgical in by modifying previously described methods. Lymphedema was created removing both inguinal popliteal lymph nodes together with surrounding fat pads, followed silicone splint placement region. Using this modified model, analyzed...
Abstract The timing of cleft lip nose surgery remains controversial. less invasive the procedure at time primary repair, growth and development is affected. Therefore, nasal-stenting component presurgical nasoalveolar molding has increasingly been used. However, not all centers use such treatment. Conventional postsurgical placement silicone nasal retainers popular. No report yet compared stenting (preNS) retainer (postNR). In this study, postoperative form outcomes after repair using preNS...
Mesenchymal stem cells or their conditioned medium improve chronic wound healing, and effect is enhanced by hypoxia. Diabetic foot ulcers are wounds characterized abnormal delayed which frequently require amputation. The authors evaluated the of topical application from hypoxically cultured amnion-derived mesenchymal on healing in diabetic mice.Amnion-derived were under 21% oxygen to prepare normoxic 1% hypoxic medium. Hydrogels containing standard medium, topically applied excisional mice...
Klippel-Trenaunay syndrome (KTS) is a rare slow-flow combined vascular malformation with limb hypertrophy. KTS thought to lie on the PIK3CA-related overgrowth spectrum, but reports are limited. PIK3CA encodes p110α, catalytic subunit of phosphatidylinositol 3-kinase (PI3K) that plays an essential role in PI3K/AKT/mammalian target rapamycin (mTOR) signaling pathway. We aimed demonstrate clinical utility targeted next-generation sequencing (NGS) identifying mosaicism archival formalin-fixed...
There is no consensus on the most appropriate treatment for patients with large to giant congenital melanocytic naevi (CMN) because of risk melanoma development. Surgical excision followed by skin grafting or expanded coverage may cause unfavourable scarring. a balance be achieved between minimizing disfiguring appearance and malignant change. The pulsed dye laser (PDL) commonly used vascular lesions highly absorbed melanin haemoglobin. Its pulse duration longer than that Q-switched ruby...
Background: Although Klippel-Trénaunay syndrome is a mixed vascular malformation characterized by abnormal growth in the extremities, no uniform diagnostic criteria have been established because of variety its manifestation. Consequently, anatomical analysis based on comparison study has reported. In this study, authors determine frequency various malformations and assess any statistical relationship between type/location terms length girth. Methods: Thirty-five patients with satisfying...
Lymph node transplantation is being increasingly recognized as a method of reconstruction the lymphatic system for treatment lymphedema. However, mechanisms regulating connections between vessels and lymph nodes remain poorly understood. The objective this study was to examine whether removal popliteal (PLN) could result in rerouting flow single transplanted nonvascularized reconnect with vessel restore flow.Thirty-six mice were allocated undergo resection PLN alone (group 1) or after 2)....
OBJECTIVE To investigate the incidence of unilateral hypodynamic palate (UHP) and velopharyngeal insufficiency (VPI) in hemifacial microsomia (HFM), to determine dysmorphic manifestations having significant associations with UHP/VPI HFM. STUDY DESIGN This was a nonrandomized study 48 patients HFM without cleft palate. The correlation between each anomaly analyzed statistically. In addition, we observed 4 examine influence on speech. RESULTS UHP 50.0% that VPI 14.6%. All had UHP. Severe...
Reconstruction of upper eyelid defects should aim for a moveable lid with perfect corneal protection and good aesthetic quality. Numerous procedures to reconstruct large have been reported, but these methods require 2-stage procedures. A new method reconstructing full-thickness after tumor excision in single stage was presented this study. The preferred technique uses excess skin as an advancement flap together ear cartilage graft the lining. performed using excision. rectangular outlined on...