A5110060117- Intracranial Aneurysms: Treatment and Complications
- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury and Neurovascular Disturbances
- Musculoskeletal pain and rehabilitation
- Spinal Dysraphism and Malformations
- Neurosurgical Procedures and Complications
- Spine and Intervertebral Disc Pathology
- Vascular Malformations Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Spinal Fractures and Fixation Techniques
- Glioma Diagnosis and Treatment
- Pelvic and Acetabular Injuries
- Neurological disorders and treatments
- Spinal Hematomas and Complications
- Spinal Cord Injury Research
- Global Health Workforce Issues
- Primary Care and Health Outcomes
- HER2/EGFR in Cancer Research
- Adenosine and Purinergic Signaling
- Trauma and Emergency Care Studies
- Fetal and Pediatric Neurological Disorders
- Patient-Provider Communication in Healthcare
- Testicular diseases and treatments
- Healthcare Systems and Technology
- Obsessive-Compulsive Spectrum Disorders
Geisinger Medical Center
2020
Geisinger Health System
2019
Yale University
2011-2018
Yale New Haven Hospital
2014-2016
Yale Cancer Center
2014
Temple University
2013
Gdańsk Medical University
2012
Hospital of the University of Pennsylvania
2012
Identification of the epidermal growth factor receptor variant III (EGFRvIII) mutation in glioblastoma has become increasingly relevant optimization therapy. Traditionally, determination tumor EGFRvIII-expression relied on tissue-based diagnostics. Here, we assess accuracy magnetic resonance perfusion-weighted imaging (MR-PWI) discriminating EGFRvIII-expressing subtype. We analyzed RNA from 132 primary human tissue samples by reverse-transcription polymerase chain reaction (RT-PCR) for...
Surgery for subdural hematoma (SDH) is a commonly performed neurosurgical procedure. This study identifies patient characteristics associated with adverse outcomes and prolonged length of stay (LOS) in patients who underwent surgical treatment SDH.All the American College Surgeons National Surgical Quality Improvement Program (ACS NSQIP) were treated via craniotomy or craniectomy SDH between 2005 2012 identified. Patient demographics, comorbidities, 30-day described. Multivariate regression...
In Brief Study Design. A retrospective study of surgically treated patients with acute traumatic central cord syndrome (ATCCS) from the National Trauma Data Bank Research Set. Objective. To determine association time to surgery, pre-existing comorbidities, and injury severity on mortality adverse events in ATCCS. Summary Background Data. Although earlier surgery has been shown be beneficial for other spinal injuries, literature is mixed regarding appropriate timing after Traditionally, this...
Patients undergoing evaluation for musculoskeletal concerns are often seen by a physician and physical therapist in the in-person setting sequential manner. This process typically delays onset of nonoperative care, inclusive therapy, creates risk inadequate clinical collaboration between therapist. To address these issues, we designed novel initial patient to group visit which both specialty-trained simultaneously evaluate together digital encounter. The aim study is gain insights from...
OBJECT Extradural decompression is a minimally invasive technique for treating Chiari malformation Type I (CM-I) that avoids the complications of dural opening. While there no agreement on which surgical method optimal, mounting evidence demonstrates extradural effectively treats clinical symptoms, with minimal reoperation rate. Neurological symptoms such as headache may be related to obstructed flow CSF, and one aspect successful improved CSF dynamics. In this series, authors report their...
Object Myelomeningocele (MMC) is characterized by a defect in caudal neurulation and appears at birth with constellation of neuroanatomical abnormalities, including Chiari malformation Type II. The authors investigated the effects antenatal versus postnatal repair MMC through quantitative analysis morphometric changes posterior fossa (PF). Methods retrospectively reviewed records 29 patients who underwent utero repair, 24 114 fetal pediatric controls. Tonsillar displacement, cerebellum...
The etiology of os odontoideum has been debated in the literature since condition was initially described. authors present case a 4-year-old girl who found to have an with atlantoaxial instability after motor vehicle collision. Imaging performed 3 years earlier demonstrated incompletely ossified, cartilaginous, orthotopic separated from body odontoid process at level secondary ossification center short process. This presents earliest imaging demonstration presence congenital center. review...
Introduction: Despite advancements in medical and surgical therapies, clinical outcomes of aneurysmal subarachnoid hemorrhage (aSAH) continue to be poor. Currently, aSAH pathophysiology remains poorly understood. No biomarkers are commonly used the setting. This exploratory study metabolomics profiling identify global metabolic changes metabolite predictors long-term outcome using cerebrospinal fluid (CSF) samples patients.Methods methods: Gas chromatography time-of-flight mass spectrometry...
A case-control genome-wide association study (GWAS) on spondylosis.Leveraging Geisinger's MyCode initiative's multimodal dataset, we aimed to identify genetic associations with degenerative spine disease.Degenerative conditions are a leading cause of global disability; however, the underpinnings these remain under-investigated. Previous studies using candidate-gene approach suggest risk for conditions, but large-scale GWASs lacking.We identified 4434 patients diagnosis spondylosis ICD codes...
Spinal teratomas comprise a rare subset of spinal cord tumors, and here, we describe an even rarer childhood thoracic extradural-intracanalicular teratoma. The clinical presentation, management, pathophysiology these tumors are reviewed to promote recognition guide treatment lesions.We report the case 21-month-old boy who presented with marked spasticity, as well failure ambulate meet motor milestones. Additionally, provide literature review teratomas, including their work-up,...
Background: Subependymomas are slow-growing, benign ependymal neoplasms histologically characterized as grade I tumors. On the other hand, ependymomas higher-grade tumors of neuroectodermal origin that share a predilection for fourth ventricle. Given these can occur simultaneously mixed lesions, features raise clinical suspicion combined pathology warrant surgical resection definitive diagnosis and potential cure. Case report: A 61-year-old ambidextrous male presented with headache an MRI...
To evaluate the effects of an interdisciplinary care team (ICT) model delivered by telemedicine on patients with low back pain (LBP).Retrospective analysis deidentified pre-existing data.Retrospective observational study presenting LBP to a nationwide practice using ICT model.Over 9-month period all diagnosis related and who had evaluation (medical doctor, advanced provider, health coach, physical therapist) were included in (n=36). A minimum 2 follow-up therapy visits required for...