A5016107655- Cancer and Skin Lesions
- Urinary and Genital Oncology Studies
- Bladder and Urothelial Cancer Treatments
- Tumors and Oncological Cases
- Lung Cancer Treatments and Mutations
- Nonmelanoma Skin Cancer Studies
- Breast Lesions and Carcinomas
- Cancer, Hypoxia, and Metabolism
- Medical Imaging and Pathology Studies
- Metabolism, Diabetes, and Cancer
- Occupational and environmental lung diseases
- Ovarian cancer diagnosis and treatment
- Soft tissue tumor case studies
- Autophagy in Disease and Therapy
- Law, Rights, and Freedoms
- Cancer Treatment and Pharmacology
- Genital Health and Disease
- Sarcoma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Spine and Intervertebral Disc Pathology
- Dermatological and COVID-19 studies
- MRI in cancer diagnosis
- Metastasis and carcinoma case studies
- Salivary Gland Tumors Diagnosis and Treatment
- Telomeres, Telomerase, and Senescence
The University of Texas MD Anderson Cancer Center
2019-2024
Penn State Milton S. Hershey Medical Center
2018-2020
Commonwealth Medical College
2020
Pennsylvania State University
2019
Reprogrammed metabolism and cell cycle dysregulation are two cancer hallmarks. p16 is a inhibitor tumor suppressor that upregulated during oncogene-induced senescence (OIS). Loss of allows for uninhibited progression, bypass OIS, tumorigenesis. Whether loss affects pro-tumorigenic unclear. We report suppression plays central role in reprogramming by increasing nucleotide synthesis. This occurs activation mTORC1 signaling, which directly mediates increased translation the mRNA encoding...
We investigate the clinical history, past medical and risk status in women with benign intraductal papillomas(IDP). observed an upgrade rate of 3.9% to ductal carcinoma situ (DCIS) 10.7% a high-risk lesion. Prior or concurrent atypia cancer had significant increase upgrade. Surgical excision papillomas is recommended especially patients history malignancy.
To investigate the gene mutational profile of urachal carcinoma in correlation with its clinicopathologic features.We analyzed genetic mutations 30 cases by next-generation sequencing (NGS) test. Histologic slides and clinical data were reviewed.The patients included 21 men 9 women, a mean age 53 years (range, 24-75 years). The carcinomas mucinous (11), enteric (10), signet ring cell (8), high-grade neuroendocrine (1) subtypes. Targeted NGS analysis demonstrated all tumors (mean, 2; range,...
A case-control genome-wide association study (GWAS) on spondylosis.Leveraging Geisinger's MyCode initiative's multimodal dataset, we aimed to identify genetic associations with degenerative spine disease.Degenerative conditions are a leading cause of global disability; however, the underpinnings these remain under-investigated. Previous studies using candidate-gene approach suggest risk for conditions, but large-scale GWASs lacking.We identified 4434 patients diagnosis spondylosis ICD codes...
Programmed death-ligand 1 (PD-L1) expression is a biomarker for cancer immunotherapy. Diabetes mellitus type-2 comorbid disease associated with adverse outcomes in Non-Small Cell Lung Cancer (NSCLC). We aimed to investigate the differences PD-L1 diabetics. A matched case-control cohort of surgically-resected NSCLC was assembled from an early multicenter study (PMID: 19152440). immunohistochemistry (Clone 22C3) graded by tumor positive score (TPS) system (TPS0: no staining; TPS1: <1%; TPS2:...
Sixty-four cases of sarcomatoid pleural mesothelioma represent the basis this study. The patients are 51 men and 13 women between ages 42 79 years, who presented with symptoms chest pain, cough, weight loss. Diagnostic imaging showed presence diffuse thickening encasement lung parenchyma in all cases. All had surgical resection via extrapleural pneumonectomy. By immunohistochemistry, were positive for cytokeratin AE1/AE3; however, reactivity other markers including keratin 5/6, calretinin,...
DPC4 immunohistochemistry (IHC) is usually part of the work-up mucinous neoplasms in ovary where distinction between an ovarian primary and metastatic pancreaticobiliary adenocarcinoma (PanACa) must be made. Although IHC lost about 55% (46%-61%) PanACas typically retained most neoplasms, no study has evaluated expression this marker a large cohort arising or involving gynecologic (GYN) organs. In study, we retrospectively analyzed total 251 tumors lesions related to GYN tract which stain was...
Underfilling of blood culture bottles decreases the sensitivity culture. We attempt to increase average fill volumes (ABCFVs) through an educational program.Partnerships were established with four hospital units (surgical intensive care unit [SICU], medical [MICU], intermediate [MIMCU], and hematology oncology [HEME/ONC]). ABCFVs continuously tracked communicated each monthly. Educational sessions provided unit.ABCFVs for SICU, MICU, MIMCU, HEME/ONC 4.8, 5.0, 6.3 mL/bottle, respectively....
Thymic typical and atypical carcinoids are rare appear to be more aggressive than similar tumors in other sites. We retrospectively analyzed a group of biomarkers that hold therapeutic prognostic utility, 27 these tumors. All cases were immunohistochemically stained with PAX5, MET, CRMP5, paxillin, p21, p27, EZH2, PDL-1, Ki-67, then H-scored. Clinicopathologic survival data statistically against staining (χ 2 test). Five- 10-year-survival rates 53% 18%, respectively. Mitotic counts ≥4 per mm...
Summary Reprogrammed metabolism and cell cycle dysregulation are two cancer hallmarks. p16 is a inhibitor tumor suppressor that upregulated during oncogene-induced senescence (OIS). Loss of allows for uninhibited progression, bypass OIS, tumorigenesis. Whether loss affects pro-tumorigenic unclear. We report suppression plays central role in reprogramming by increasing nucleotide synthesis. This occurred via activation mTORC1 signaling, which directly mediated increased translation the mRNA...