A5058558667- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Virology and Viral Diseases
- Antibiotic Resistance in Bacteria
- Vaccine Coverage and Hesitancy
- Poxvirus research and outbreaks
- Diagnosis and treatment of tuberculosis
- Herpesvirus Infections and Treatments
- Eosinophilic Esophagitis
- Ginseng Biological Effects and Applications
- Food Security and Health in Diverse Populations
- Telemedicine and Telehealth Implementation
- Gut microbiota and health
- COVID-19 and Mental Health
- IL-33, ST2, and ILC Pathways
- Mobile Health and mHealth Applications
- Electronic Health Records Systems
- Metabolomics and Mass Spectrometry Studies
- Phenothiazines and Benzothiazines Synthesis and Activities
- Mosquito-borne diseases and control
- Genomics and Phylogenetic Studies
- Autism Spectrum Disorder Research
- Zoonotic diseases and public health
- Immune Cell Function and Interaction
- Microbial Natural Products and Biosynthesis
University of Oxford
2023-2025
Tulane University
2024
Imperial College London
2020-2022
Transnational Press London
2021
Centre for Inflammation Research
2018
Medical Research Council
2018
University of Edinburgh
2018
cAMP and antimicrobial susceptibility in mycobacteriaAntimicrobial tolerance, the ability to survive exposure antimicrobials via transient nonspecific means, promotes development of resistance (AMR). The study molecular mechanisms that result tolerance is therefore essential for understanding AMR. In gram-negative bacteria, second messenger molecule 3'',5''-cAMP has been previously shown be involved mycobacteria, however, role difficult probe due its particular complexity. order address this...
<title>Abstract</title> Background Stigma has emerged as a prominent public health challenge in the 2022–2024 global mpox outbreak, impeding outbreak control efforts and well-being of affected individuals. Addressing stigma is priority for improving infection prevention control. Despite its frequent mention policy discourse, robust assessment lacking. This study investigated causes, manifestations, impacts mpox-related United Kingdom (UK). Methods We conducted an online, mixed-methods...
Abstract Inflammatory bowel disease ( IBD ) is a condition of chronic inflammatory intestinal disorder with increasing prevalence but limited effective therapies. The purine metabolic pathway involved in various processes including . However, the mechanisms through which metabolism modulates remain to be established. Here, we found that mucosal expression genes altered patients active ulcerative colitis UC ), associated elevated gene signatures group 3 innate lymphoid cell ILC 3)–interleukin...
Background The integration of digital health (eHealth) interventions into primary healthcare systems has gained recognition lately in Low- and Middle-Income Countries (LMICs) to enhance quality, accessibility, efficiency. These may offer effective strategies mitigating the burden chronic diseases by facilitating access remote optimising its processes. This scoping review aims identify assess eHealth implemented care settings LMICs for further development adaptation. Methods analysis We will...
Abstract Antimicrobial tolerance (AMT) is the gateway to development of antimicrobial resistance (AMR) and therefore a major issue that needs be addressed. The second messenger cyclic-AMP (cAMP), which conserved across all taxa, involved in propagating signals from environmental stimuli converting these into response. In bacteria, such as M. tuberculosis , P. aeruginosa V. cholerae B. pertussis cAMP has been implicated virulence, metabolic regulation gene expression. However, signalling...
Abstract In vitro whole blood infection models are used for elucidating the immune response to Mycobacterium tuberculosis ( Mtb ). They exhibit commonalities but also differences, in vivo transcriptional during natural human disease. Here, we present a description of concordant and discordant components blood, quantified through profiling an model compared from patients with We identified concordantly discordantly expressed gene modules performed silico cell deconvolution. A high degree...
Despite being the number one cause of death from an infectious disease, little is known 7 phylogenetic lineages Mycobacterium tuberculosis (Mtb). These are thought to have adapted differently their human hosts, as they geographically localised. As a result, show variation at phenotype level, such virulence and ability develop antibiotic resistance, genomic in single nucleotide polymorphisms (SNPs). We linked differences SNPs between metabolites (i.e. what ultimately produced by cell)....
Abstract In vitro whole blood infection models are used for elucidating the immune response to Mycobacterium tuberculosis ( Mtb ). They exhibit commonalities but also differences, in vivo transcriptional during natural human disease. Here, we present a description of concordant and discordant components blood, quantified through profiling an model compared from patients with We identified concordantly discordantly expressed gene modules performed silico cell deconvolution. A high degree...