A5029922762- Gut microbiota and health
- Cancer-related Molecular Pathways
- Probiotics and Fermented Foods
- Insect and Arachnid Ecology and Behavior
- Carbohydrate Chemistry and Synthesis
- Natural product bioactivities and synthesis
- Natural Compound Pharmacology Studies
- Microbial Metabolites in Food Biotechnology
- Synthesis of Organic Compounds
- Cancer, Hypoxia, and Metabolism
- Flavonoids in Medical Research
- Gene expression and cancer classification
- Genetic Mapping and Diversity in Plants and Animals
- Insect Utilization and Effects
- Genetic Associations and Epidemiology
- Glycosylation and Glycoproteins Research
- Genetic and phenotypic traits in livestock
- Cell death mechanisms and regulation
- PARP inhibition in cancer therapy
- Milk Quality and Mastitis in Dairy Cows
- Proteoglycans and glycosaminoglycans research
- Digital Image Processing Techniques
- Traditional Chinese Medicine Analysis
- Neurobiology and Insect Physiology Research
- Nanocomposite Films for Food Packaging
East China University of Science and Technology
2019-2024
Chinese Academy of Sciences
2018-2021
Institute of Zoology
2018-2021
Hunan Provincial People's Hospital
2020
Hangzhou Normal University
2018
Army Medical University
2015-2016
Affiliated Hospital of Hangzhou Normal University
2015
China Pharmaceutical University
2008-2010
Koumiss is a traditionally fermented mare's milk described with health-promoting potentials for decades. However, only few studies focused on the probiotic strains isolated from koumiss. In this study, we collected koumiss samples Inner Mongolian pasturing area of China and selected promising strain Lactobacillus helveticus, isolate NS8, based survival abilities in gastrointestinal tract (GIT) adhesion to intestinal endothelial cells vitro. As ability positively modulate host immune response...
Genotype imputation is now routinely applied in genome-wide association studies (GWAS) and meta-analyses. However, most of the imputations have been run using HapMap samples as reference, low frequency rare variants (minor allele (MAF) < 5%) are not systemically assessed. With emergence next-generation sequencing, large reference panels (such 1000 Genomes panel) available to facilitate these variants. Therefore, order estimate performance imputation, we imputed 153 individuals, each whom had...
Abstract Background and Aim Chronic inflammation is a major contributor to the initiation progression of cancers. Lactobacillus helveticus NS8, which was originally separated from fermented koumiss, exhibited anti‐inflammatory functions in our prior studies. In this study, NS8 investigated for its potential prevent colitis‐associated colorectal cancer (CAC). Methods The protective effects against CAC explored by employing azoxymethane plus dextran sodium sulfate‐induced carcinogenesis mouse...
Chitosan (CS) has limited capacity for Ca(II)-adsorption abilities. Here, glutaraldehyde cross-linked chitosan (GLA-CTS) and maltose (MAL-CTS) were obtained by physical chemical modifications to improve the adsorption of Ca2+. By comparing kinetics isotherm, capabilities GLA-CTS MAL-CTS reached 112.27 ± 2.63 240.38 31.88 mg/g in presence concentrations 3000 mg/L Ca2+, which about 2.1 4.6 times than CS. The structures resulting calcified complexes profiled SEM, XPS, FT-IR, 13C NMR. Unlike...
Abstract Oroxylin A, a naturally occurring monoflavonoid extracted from Scutellariae radix, exhibits anticancer activity and induces apoptosis in human hepatocellular carcinoma HepG2 cells according to our previous data. In this study, we investigate whether p53 is involved oroxylin A‐triggered viability inhibition induction cancer cells. panel of different cell lines, more potent inhibitory effects A were observed wtp53 than those mtp53 or p53‐null Moreover, p53‐siRNA‐transfected showed...
Synthesis of bacterial cell surface l-glycero-d-manno-heptose (l,d-Hep)- and d-glycero-d-manno-heptose (d,d-Hep)-containing higher carbon sugars is a challenging task. Here, we report convenient efficient approach for the synthesis l,d-Hep d,d-Hep building blocks. Using l-lyxose d-ribose as starting materials, this features diastereoselective Mukaiyama-type aldol reactions key steps. On basis synthetic blocks, achieved first stereoselective unique α-l,d-Hep-(1→3)-α-d,d-Hep-(1→5)-α-Kdo core...
Abstract Background The black soldier fly ( Hermetia illucens ) has significant economic potential. larvae can be used in financially viable waste management systems, as they are voracious feeders able to efficiently convert low-quality into valuable biomass. However, most studies on H. recent decades have focused optimizing their breeding and bioconversion conditions, while information biology is limited. Methods About 200 fifth instar well-fed were sacrificed this work. liquid...
A gold(<sc>i</sc>)-promoted α-selective glycosylation approach with sialyl<italic>ortho</italic>-hexynylbenzoates as donors is developed for the latent-active synthesis of α-(2 → 9)-linked oligosialic acids.
Abstract Chikusetsusaponin IVa butyl ester (CS-IVa-Be) is a triterpene saponin that acts as novel IL6R antagonist for inducing breast cancer cell apoptosis. However, the structure–activity relationship this class of saponins remains unclear. Here, we report gram-scale synthesis CS-IVa-Be and efficient preparation eight its analogues. was demonstrated to have significant antitumor activities against MDA-MB-231, HepG2, A549 cells. When one sugar residues at either 3-OH or 28-COOH position...
The up‑frameshift suppressor 1 homolog (UPF1) RNA surveillance gene is a core element in the nonsense‑mediated decay (NMD) pathway, which impacts broad spectrum of biological processes cell‑specific manner. In present study, contribution NMD pathway to psoriasis lesions and its moderating effects on keratinocytes was reported. Sanger sequencing for skin scales from two patients with identified mRNA mutations (c.2935_2936insA c.2030‑2081del) UPF1 gene. somatic mutants produced truncated...
ABSTRACT To investigate the construction of histological section datasets in basal ganglia digitized human brain to provide a reference for meso‐level data acquisition. A fresh adult from cadaver with no neurological disease was selected, and tissue blocks right hemisphere extracted using visualization method, followed by pretreatments including gradient dehydrating, gelatin‐embedding setting calibration points. And then cryosectioned into 60‐μm‐thick coronal sections sectional images were...
Figure S1. Autoaggregation percentage of L. helveticus NS8 in 5 hours. The sedimentation rate strains was measured over a period h under identical conditions. isolate exhibited the highest cell autoaggregation. autoaggregating phenotype so strong that half bacterium have formed precipitate 1 h, while other bacterial suspensions showed constant turbidity with little precipitate. (PDF 159 kb)
Table S1. Lewis acid-base characteristics of the bacterial cell surfaces. Adhesion to chloroform (electron acceptor) and ethyl acetate donor) was also tested assess All strains didnâ t show significant difference between affinity acetate. (PDF 46 kb)