A5082510891- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Bipolar Disorder and Treatment
- Olfactory and Sensory Function Studies
- Gut microbiota and health
- Tryptophan and brain disorders
- Neural dynamics and brain function
- Circadian rhythm and melatonin
- Receptor Mechanisms and Signaling
- Photoreceptor and optogenetics research
- Neuroinflammation and Neurodegeneration Mechanisms
- Mental Health Research Topics
- Allergic Rhinitis and Sensitization
- Vagus Nerve Stimulation Research
- Medical research and treatments
- Protein Kinase Regulation and GTPase Signaling
- Diet and metabolism studies
- Stress Responses and Cortisol
- Neurotransmitter Receptor Influence on Behavior
- Stress and Burnout Research
- Treatment of Major Depression
- Biochemical Analysis and Sensing Techniques
Institut Pasteur
2018-2024
Sorbonne Université
2020-2024
Université Sorbonne Nouvelle
2020-2024
Université Paris Cité
2022-2024
Centre National de la Recherche Scientifique
2018-2023
Laboratoire de Neurosciences Cognitives
2019-2020
Université Paris Sciences et Lettres
2019-2020
Inserm
2019-2020
École Normale Supérieure - PSL
2019-2020
Laboratoire Psychologie de la Perception
2020
Chronic stress constitutes a major risk factor for depression that can disrupt various aspects of homeostasis, including the gut microbiome (GM). We have recently shown GM imbalance affects adult hippocampal (HPC) neurogenesis and induces depression-like behaviors, with exact mechanisms being under active investigation. Here we hypothesized vagus nerve (VN), key bidirectional route communication between brain, could relay effects stress-induced changes on HPC plasticity behavior. used fecal...
Major depressive disorders (MDDs) constitute a leading cause of disability worldwide and current pharmacological treatments are partially effective. The gut microbiota (GM) has recently emerged as target therapeutic interest for MDDs. In this study, we transfer GM from mice that sustained unpredictable chronic mild stress (UCMS) to healthy recipient mice. fecal induces despair-like behavior, decreases neurogenesis in the hippocampus (HpC), impairs antidepressant neurogenic effects standard...
In the neocortex, synaptic inhibition shapes all forms of spontaneous and sensory evoked activity. Importantly, inhibitory transmission is highly plastic, but functional role plasticity unknown. mouse barrel cortex, activation layer (L) 2/3 pyramidal neurons (PNs) elicits strong feedforward (FFI) onto L5 PNs. We find that FFI involving parvalbumin (PV)-expressing cells strongly potentiated by postsynaptic PN burst firing. modifies excitation-to-inhibition (E/I) ratio, modulates gain, alters...
Abstract Bipolar disorders are defined by recurrences of depressive and manic episodes. The pathophysiology is still unknown, translating clinical symptoms into behaviors explorable in animal models challenging. Animal bipolar disorder do not exist because cyclicity the disease impossible to mimic, it therefore necessary study mania depression separately. Beyond mood, emotional biases differentiate states humans. Mania associated with positive biases, e.g. stimuli become more rewarding less...
Negative bias is an essential characteristic of depressive episodes leading patients to attribute more negative valence environmental cues. This affects all levels information processing including emotional response, attention and memory, the development maintenance symptoms. In this context, pleasant stimuli become less attractive unpleasant ones aversive, yet related neural circuits underlying remain largely unknown. By studying a mice model for depression chronically receiving...
Chronic stress constitutes one of the strongest risk factors for depression and can disrupt various aspects homeostasis, including gut microbiota composition. We found that stress-induced changes in promote decrease adult hippocampal neurogenesis upon transfer to antibiotic-treated recipient mice. Subdiaphragmatic vagotomy abrogated microbiota-induced effects on behavior neurogenesis, suggesting influence brain plasticity through vagal afferents.
Abstract In the neocortex, synaptic inhibition shapes all forms of spontaneous and sensory-evoked activity. Importantly, inhibitory transmission is highly plastic, but functional role plasticity unknown. mouse barrel cortex, activation layer 2/3 PNs elicited strong feed-forward perisomatic (FFI) onto 5 PNs. We found that FFI involving PV cells was strongly potentiated by postsynaptic PN burst firing. modified excitation-to-inhibition (E/I) ratio, modulated gain altered information transfer...
Major depressive disorders (MDD) constitute a leading cause of disability worldwide and current pharmacological treatments are partially effective with high relapse rates. The gut microbiota has recently emerged as potential target therapeutic interest for MDD, yet the precise mechanisms remain unknown. In present study, we transferred fecal from chronically stressed mice to non-stressed recipient mice. We found that chronic stress resulted in dysbiosis was transferable transmitted induced...
Abstract Negative emotional bias is an essential hallmark of depression reflected by negative shift in hedonic valence assignment to stimuli. Pleasant cues become less attractive and unpleasant ones more aversive. Given the crucial role amygdala coding, we hypothesize that specific basolateral (BLA) circuits alterations might support associated with depressive states. Using a translational assay, evaluate odor animal model for chronically administered corticosterone (CORT). We show...