A5064593721- Chromosomal and Genetic Variations
- Plant Reproductive Biology
- Plant Molecular Biology Research
- Genetic Mapping and Diversity in Plants and Animals
- Genomics and Phylogenetic Studies
- Photosynthetic Processes and Mechanisms
- Evolution and Genetic Dynamics
- Plant nutrient uptake and metabolism
- Genetic diversity and population structure
- Plant Disease Resistance and Genetics
- Plant Virus Research Studies
- Plant tissue culture and regeneration
- DNA Repair Mechanisms
- Plant-Microbe Interactions and Immunity
- Plant Parasitism and Resistance
- Plant and animal studies
- Plant pathogens and resistance mechanisms
- Plant Gene Expression Analysis
- Plant Genetic and Mutation Studies
- Plant Physiology and Cultivation Studies
- Protein Structure and Dynamics
- Plant Stress Responses and Tolerance
- Legume Nitrogen Fixing Symbiosis
- Microtubule and mitosis dynamics
- Genetic and phenotypic traits in livestock
ETH Zurich
2019-2025
Institute of Plant Molecular Biology
2024
École Polytechnique Fédérale de Lausanne
2020-2022
Child Trends
2016-2022
John Innes Centre
2015-2021
University of Nottingham
2020
Evolutionary Genomics (United States)
2014-2019
Norwich Research Park
2016-2019
Harvard University
2009-2018
Institut Jean-Pierre Bourgin
2018
Epistatic interactions between genes are a major factor in evolution. Hybrid necrosis is an example of deleterious phenotype caused by epistatic that observed many intra- and interspecific plant hybrids. A large number hybrid cases share phenotypic similarities, suggesting common underlying mechanism across wide range species. Here, we report approximately 2% intraspecific crosses Arabidopsis thaliana yield F1 progeny express when grown under conditions typical their natural habitats. We...
Abstract Reduced representation genome‐sequencing approaches based on restriction digestion are enabling large‐scale marker generation and facilitating genomic studies in a wide range of model nonmodel systems. However, sampling chromosomes may introduce bias allele frequency estimation due to polymorphisms sites. To explore the effects this nonrandom its sensitivity different evolutionary parameters, we developed coalescent‐simulation framework mimic biased recovery restriction‐based...
Significance Serpentine barrens are enormously hostile to plant life. Understanding how plants survive such a perfect storm of low mineral nutrient, drought prone, and toxic metal rich conditions offers powerful model adaptation may help design resilient crops. Advances in genomics enable population-wide views selection deep insight into demographic histories. These approaches agnostic phenotype can indicate which traits were most important complex adaptations and, at the same time, provide...
The rediscovery of Mendel's work showing that the heredity phenotypes is controlled by discrete genes was followed reconciliation Mendelian genetics with evolution natural selection in middle last century Modern Synthesis. In past two decades, dramatic advances genomic methods have facilitated identification loci, genes, and even individual mutations underlie phenotypic variants are putative targets selection. Moreover, these also changed how we can study adaptation flipping problem around,...
The patterned expression of floral homeotic genes in Arabidopsis depends on the earlier action meristem-identity such as LEAFY , which encodes a transcription factor that determines whether meristem will generate flowers instead leaves and shoots. protein, is expressed throughout flower, participates activation genes, are specific regions flower. Analysis LEAFY-responsive enhancer gene AGAMOUS indicates direct interaction with this required for its activity plants. Thus, upstream regulator genes.
The homologous transcription factors FLORICAULA of Antirrhinum and LEAFY Arabidopsis share conserved roles in flower meristem identity floral patterning. While for FLORICAULA/LEAFY homologs development have been demonstrated numerous dicots, little is known about the function these genes more distantly related flowering plants, monocots. We used reverse genetics to investigate role two duplicate maize (Zea mays L. ssp. mays) - a monocot species with dramatically different inflorescence...
As Arabidopsis thaliana is increasingly employed in evolutionary and ecological studies, it essential to understand patterns of natural genetic variation the forces that shape them. Previous work focusing mostly on global regional scales has demonstrated importance historical events such as long-distance migration colonization. Far less known about role contemporary factors or environmental heterogeneity generating diversity at local scales. We sampled 1,005 individuals from 77 closely...
Abstract The onset of flowering is an important adaptive trait in plants. small ephemeral species Arabidopsis thaliana grows under a wide range temperature and day-length conditions across much the Northern hemisphere, number flowering-time loci that vary between different accessions have been identified before. However, only few studies addressed species-wide genetic architecture control. We taken advantage set 18 distinct present common diversity A. mapped quantitative (QTL) for time 17 F2...
Genome duplication, which results in polyploidy, is disruptive to fundamental biological processes. duplications occur spontaneously a range of taxa and problems such as sterility, aneuploidy, gene expression aberrations are common newly formed polyploids. In mammals, genome duplication associated with cancer spontaneous abortion embryos. Nevertheless, stable polyploid species both plants animals. Understanding how natural selection enabled these overcome early challenges can provide...
Whole-genome duplication, which leads to polyploidy, has been implicated in speciation and biological novelty. In plants, many species exhibit ploidy variation, is likely representative of an early stage the evolution polyploid lineages. To understand such multiploidy systems, we must address questions as whether lineage(s) had a single or multiple origins, admixture occurs between ploidies, timescale over variation affects populations. Here analyze three genomic data sets using...
Abstract Meiosis, the specialized cell division that generates gametes, shuffles parental genomes through homologous recombination. It was reported in Drosophila a century ago, recombination rate is sensitive to temperature, but how... Meiotic genetic information from sexual species into gametes create novel combinations offspring. Thus, an important factor inheritance, adaptation, and responses selection. However, not static parameter; meiotic variation environment, especially temperature....
Whole-genome duplication (WGD), which leads to polyploidy, is implicated in adaptation and speciation. But what are the immediate effects of WGD how do newly polyploid lineages adapt them? With many studies new evolved polyploids now available, along with genes under selection polyploids, we an increasingly good position understand polyploidy generates novelty. Here, I will review consistent on biology plants, such as increase cell size, increased stress tolerance more. discuss a change...
Abstract In most organisms, the number and distribution of crossovers that occur during meiosis are tightly controlled. All chromosomes must receive at least one ‘obligatory crossover’ prevented from occurring near another by ‘crossover interference’. However, mechanistic basis this phenomenon crossover interference has remained mostly mysterious. Using quantitative super-resolution cytogenetics mathematical modelling, we investigate positioning in Arabidopsis thaliana wild-type, an...
Abstract Polyploidization is frequently associated with increased transposable element (TE) content. However, what drives TE dynamics following whole genome duplication (WGD) and the evolutionary implications remain unclear. Here, we leverage whole-genome resequencing data available for ~300 individuals of Arabidopsis arenosa , a well characterized natural diploid-autotetraploid plant species, to address these questions. Based on 43,176 insertions detect in genomes, demonstrate that relaxed...
Polyploidy, which results from whole genome duplication (WGD), has shaped the long-term evolution of eukaryotic genomes in all kingdoms. Polyploidy is also implicated adaptation, domestication, and speciation. Yet when WGD newly occurs, resulting neopolyploids face numerous challenges. A particularly pernicious problem segregation multiple chromosome copies meiosis. Evolution can overcome this challenge, likely through modification pairing recombination to prevent deleterious multivalent...