A5053148829- Reproductive biology and impacts on aquatic species
- Biomedical Text Mining and Ontologies
- Plant and animal studies
- Computational Drug Discovery Methods
- Species Distribution and Climate Change
- Aquaculture disease management and microbiota
- Environmental DNA in Biodiversity Studies
- Plant Molecular Biology Research
- Identification and Quantification in Food
- Semantic Web and Ontologies
- Bioinformatics and Genomic Networks
- Aquaculture Nutrition and Growth
- Weed Control and Herbicide Applications
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Gene expression and cancer classification
- Animal Genetics and Reproduction
- Genetic Mapping and Diversity in Plants and Animals
- Physiological and biochemical adaptations
- Environmental Toxicology and Ecotoxicology
- Molecular Biology Techniques and Applications
- Zebrafish Biomedical Research Applications
- Trauma Management and Diagnosis
- Ethics in Clinical Research
- Evolutionary Psychology and Human Behavior
- Per- and polyfluoroalkyl substances research
Environmental Protection Agency
2007-2020
Jinan Stomatological Hospital
2013
Stomatology Hospital
2013
VA Office of Research and Development
2010
Syngenta (United States)
2003
University of Minnesota
1999-2001
Washington University in St. Louis
2001
Rutgers, The State University of New Jersey
1996
Iowa State University
1994
The homologous transcription factors FLORICAULA of Antirrhinum and LEAFY Arabidopsis share conserved roles in flower meristem identity floral patterning. While for FLORICAULA/LEAFY homologs development have been demonstrated numerous dicots, little is known about the function these genes more distantly related flowering plants, monocots. We used reverse genetics to investigate role two duplicate maize (Zea mays L. ssp. mays) - a monocot species with dramatically different inflorescence...
Abstract Background A large quantity of nitrogen (N) fertilizer is used for crop production to achieve high yields at a significant economic and environmental cost. Efforts have been directed understanding the molecular basis plant responses N identifying N-responsive genes in order manipulate their expression, thus enabling plants use more efficiently. No studies yet delineated these transcriptional level when are grown under chronic stress regulatory elements involved response very...
The Adverse Outcome Pathway framework is increasingly used to integrate data generated based on traditional and emerging toxicity testing paradigms. As the number of AOP descriptions has increased, so need define in computable terms.Herein, we present a comprehensive annotation 172 AOPs housed AOP-Wiki as December 4, 2016 using terms from existing biological ontologies.AOP Key Events (KEs) were assigned ontology concept called Event Component, which consists Process, an Object, Action term,...
Abstract Thirty-five period locus sequences from Drosophila pseudoobscura and its siblings species, D. p. bogotana, persirnilis, miranda, were studied. A large amount of variation was found within persimilis, consistent with histories effective population sizes. however, has a severe reduction in diversity. Combined analysis per two other loci, both bogotana pseudoobscura, strongly suggest this is due to recent directional selection at or near bogotana. Since highly variable shares the low...
Fathead minnow and zebrafish are among the most intensively studied fish species in environmental toxicogenomics. To aid assessment interpretation of subtle transcriptomic effects from treatment conditions interest, better characterization understanding needed for natural variation gene expression individuals lab cultures. Leveraging transcriptomics data a number our toxicogenomics studies conducted over years, we meta-analysis nearly 600 microarrays generated ovary tissue untreated,...
Environmental health risk assessors are challenged to understand and incorporate new data streams as the field of toxicology continues adopt molecular systems biology technologies. Systematic screening reviews can help assessment teams determine which studies consider for inclusion in a human assessment. A tool systematic should be standardized transparent order consistently meet minimum quality criteria prior performing in-depth analyses data. The Omics Analysis Review (SOAR) is focused on...
A very large and rapidly growing collection of transcriptomic profiles in public repositories is potentially great value to developing data-driven bioinformatics applications for toxicology/ecotoxicology. Modeled on human connectivity mapping (Cmap) biomedical research, this study was undertaken investigate the utility an analogous Cmap approach ecotoxicology. Over 3500 zebrafish (Danio rerio) fathead minnow (Pimephales promelas) profiles, each associated with one several dozen chemical...
Development and application of transcriptomics-based gene classifiers for ecotoxicological applications lag far behind those biomedical sciences. Many such discovered thus lack vigorous statistical experimental validations. A combination genetic algorithm/support vector machines algorithm/K nearest neighbors was used in this study to search endocrine-disrupting chemicals (EDCs) zebrafish. Searches were conducted on both tissue-specific tissue-combined datasets, either across the entire...
Many organisms, including the fathead minnow (Pimephales promelas), a toxicological model organism, establish social hierarchies. The rank of each male in population is under control hypothalamic-pituitary-gonadal (HPG) axis mainly through regulation circulating androgen concentrations, which turn drive expression secondary sex characteristics (SSCs). As dominant and subordinate males an exposure study are initially different physiological conditions (i.e., differing plasma concentrations),...