A5033016821- Animal testing and alternatives
- Health Systems, Economic Evaluations, Quality of Life
- Computational Drug Discovery Methods
- Biomedical Text Mining and Ontologies
- Ethics in Clinical Research
- Research Data Management Practices
- Effects and risks of endocrine disrupting chemicals
- History and advancements in chemistry
- Chemical Safety and Risk Management
- Scientific Computing and Data Management
- Pesticide and Herbicide Environmental Studies
- Pharmacovigilance and Adverse Drug Reactions
- Agricultural safety and regulations
- Bioinformatics and Genomic Networks
- Pharmaceutical and Antibiotic Environmental Impacts
- Cancer, Stress, Anesthesia, and Immune Response
- Metabolomics and Mass Spectrometry Studies
- Peripheral Neuropathies and Disorders
- Resilience and Mental Health
- Nuclear and radioactivity studies
- Interdisciplinary Research and Collaboration
- Risk and Safety Analysis
- Quality and Safety in Healthcare
- Cancer-related cognitive impairment studies
- SARS-CoV-2 detection and testing
Joint Research Centre
2015-2023
Environmental Protection Agency
2022
Masaryk University
2022
Norwegian Institute for Water Research
2022
Maastricht University
2014
Harvard University
2014
Dana-Farber Cancer Institute
2014
European Bioinformatics Institute
2014
Wellcome Trust
2014
Imperial College London
2014
Efforts are underway to transform regulatory toxicology and chemical safety assessment from a largely empirical science based on direct observation of apical toxicity outcomes in whole organism tests predictive one which risk inferred accumulated mechanistic understanding.The adverse outcome pathway (AOP) framework provides systematic approach for organizing knowledge that may support such inference.Likewise, computational models biological systems at various scales provide another means...
The Adverse Outcome Pathway framework is increasingly used to integrate data generated based on traditional and emerging toxicity testing paradigms. As the number of AOP descriptions has increased, so need define in computable terms.Herein, we present a comprehensive annotation 172 AOPs housed AOP-Wiki as December 4, 2016 using terms from existing biological ontologies.AOP Key Events (KEs) were assigned ontology concept called Event Component, which consists Process, an Object, Action term,...
As the basis for managing risks of chemical exposure, Chemical Risk Assessment (CRA) process can impact a substantial part economy, health hundreds millions people, and condition environment. However, number properly assessed chemicals falls short societal needs due to lack experts evaluation, interference third party interests, sheer volume potentially relevant information on from disparate sources. In order explore ways in which computational methods may help overcome this discrepancy...
The adverse outcome pathway (AOP) is a conceptual construct that facilitates organisation and interpretation of mechanistic data representing multiple biological levels deriving from range methodological approaches including
Adverse Outcome Pathways (AOP) provide structured frameworks for the systematic organization of research data and knowledge. The AOP framework follows a set key principles that allow broad application across diverse disciplines related to human health, including toxicology, pharmacology, virology medical research. COVID-19 pandemic engages great number scientists world-wide is increasing with exponential speed. Diligent management strategies are employed but approaches systematically...
Adverse outcome pathways (AOPs) provide evidence for demonstrating and assessing causality between measurable toxicological mechanisms human or environmental adverse effects. AOPs have gained increasing attention over the past decade are believed to necessary steppingstone more effective risk assessment of chemicals materials moving beyond need animal testing. However, as with all types data knowledge today, be reusable by machines, i.e., machine-actionable, in order reach their full impact...
The adverse outcome pathways (AOPs) were developed to accelerate evidence-based chemical risk assessment by leveraging data from new approach methodologies. Thanks their stressor-agnostic approach, AOPs seen as instrumental in other fields. Here, we present that report non-chemical stressors along with the challenges encountered for development. Challenges regarding linked nanomaterials include non-specific molecular initiating events, limited understanding of nanomaterial biodistribution,...
Abstract Motivation: The field of toxicogenomics (the application ‘-omics’ technologies to risk assessment compound toxicities) has expanded in the last decade, partly driven by new legislation, aimed at reducing animal testing chemical but mainly as a result paradigm change toxicology towards use and integration genome wide data. Many research groups worldwide have generated large amounts such However, there is no centralized repository for archiving making these data associated tools their...
The CIAO project (Modelling the Pathogenesis of COVID-19 using Adverse Outcome Pathway framework) aims at a holistic assembly knowledge to deliver truly transdisciplinary description entire physiopathology starting with initial contact SARS-CoV-2 virus and ending one or several adverse outcomes, e.g., respiratory failure. On 27-28 January 2021, group 50+ scientists from numerous organizations around world met in 2nd AOP Design Workshop discuss depiction disease process as series key events...
Introduction The CIAO project was launched in Spring 2020 to address the need make sense of numerous and disparate data available on COVID-19 pathogenesis. Based a crowdsourcing model large-scale collaboration, has exploited Adverse Outcome Pathway (AOP) knowledge management framework built support chemical risk assessment driven by mechanistic understanding biological perturbations at different organizational levels. Hence AOPs might have real potential integrate produced through approaches...
Abstract eChemPortal erleichtert den Zugang zu Informationen über Chemikalien. Daten, die von Industrie und Wissenschaft in unterschiedlichste nationale internationale Datenbanken eingespeist wurden, stehen nun einem einheitlichen Abfrageformat zur Verfügung: physikalisch‐chemische Eigenschaften sowie Gefahren für Umwelt Gesundheit, Chemikalien ausgehen, werden übersichtlich dargestellt, Links teilnehmenden helfen bei der eingehenderen Erörterung relevanter Daten.
ChemAgora, a web application designed and developed in the context of "Data Infrastructure for Chemical Safety Assessment" (diXa) project, provides search capabilities to chemical data from resources available online, enabling users cross-reference their results with both regulatory information public databases. through an on-the-fly search, informs whether is known or not each external sources clikable links leading third-party site pages containing information. The original purpose...
This report documents the first workshop of ELIXIR Toxicology Community (Martenset al., 2023), held in Utrecht on May 28-29, 2024 (FAIRification Toxicological ResearchOutput: Leveraging Resources, 2024), as part INTOXICOM ImplementationStudy series (Integrating into ELIXIR, 2024). The maintopic meeting was FAIRification toxicological research outputs and exploring thepotential role resources this process. A team ten people from ELIXIRToxicology Community, including Marvin Martens, Penny...
Adverse Outcome Pathways (AOP) provide structured frameworks for systematic organization of research data and knowledge. The AOP framework follows a set key principles that allow broad application across diverse disciplines related to human health, including toxicology, pharmacology, virology medical research. COVID-19 pandemic engages great number scientists world-wide is increasing with exponential speed. Diligent management strategies are employed but approaches systematically organizing...