A5061133861- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Drug Transport and Resistance Mechanisms
- Long-Term Effects of COVID-19
- Gut microbiota and health
- Vitamin C and Antioxidants Research
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Liver Disease and Transplantation
- Computational Drug Discovery Methods
- Health Systems, Economic Evaluations, Quality of Life
- Diet and metabolism studies
- Pesticide Residue Analysis and Safety
- SARS-CoV-2 detection and testing
- Nanoparticles: synthesis and applications
- Pediatric Hepatobiliary Diseases and Treatments
- MicroRNA in disease regulation
- Pancreatic function and diabetes
- Pharmacological Effects and Toxicity Studies
- RNA Research and Splicing
- Organ Transplantation Techniques and Outcomes
- Trace Elements in Health
- Insect and Pesticide Research
- Biological Research and Disease Studies
- Advancements in Transdermal Drug Delivery
Joint Research Centre
2018-2024
UCLouvain
2016-2024
Université Côte d'Azur
2024
Institut de Pharmacologie Moléculaire et Cellulaire
2024
Centre National de la Recherche Scientifique
2024
University Hospital of Zurich
2020-2023
University of Zurich
2020-2023
de Duve Institute
2010-2021
Vassar College
2021
Physiol (Belgium)
2010
The regulation of synthesis, degradation, and distribution lipids is crucial for homeostasis organisms cells. sterol regulatory element-binding protein (SREBP) transcription factor family post-translationally activated in situations reduced lipid abundance activates numerous genes involved cholesterol, fatty acid, phospholipid synthesis. In this study, we provide evidence that the primary transcript SREBP2 contains an intronic miRNA (miR-33) reduces cellular cholesterol export via inhibition...
Through FXR and TGR5 signaling, bile acids (BAs) modulate lipid glucose metabolism, inflammation fibrosis. Hence, BAs returning to the liver after enteric secretion, modification reabsorption may contribute pathogenesis of non-alcoholic steatohepatitis (NASH). Herein, we characterized enterohepatic profile signaling in preclinical models NASH, explored consequences experimental manipulation BA composition.We used high-fat diet (HFD)-fed foz/foz high-fructose western diet-fed C57BL/6J mice,...
Recent data suggest that gut microbiota contributes to the regulation of host lipid metabolism. We report how fermentable dietary fructo-oligosaccharides (FOS) control hepatic steatosis induced by n-3 PUFA depletion, which leads alterations similar those observed in non-alcoholic fatty liver disease patients.C57Bl/6J mice fed an PUFA-depleted diet for 3 months were supplemented with FOS during last 10 days treatment. FOS-treated exhibited higher caecal Bifidobacterium spp. and lower...
The 2018 LUCAS (Land Use and Coverage Area frame Survey) Soil Pesticides survey provides a European Union (EU)-scale assessment of 118 pesticide residues in more than 3473 soil sites. This study responds to the policy need develop risk-based indicators for pesticides environment. Two mixture risk are presented based, respectively, on lowest median available No Observed Effect Concentration (NOEC
Intestinal epithelial homeostasis depends on a tightly regulated balance between intestinal cell (IEC) death and proliferation. While the disruption of several IEC regulating factors result in inflammation, loss anti-apoptotic BCL2 family members BCL2L1 has no effect mice. We investigated functions antiapoptotic protein MCL1, another member family,
Adverse outcome pathways (AOPs) provide evidence for demonstrating and assessing causality between measurable toxicological mechanisms human or environmental adverse effects. AOPs have gained increasing attention over the past decade are believed to necessary steppingstone more effective risk assessment of chemicals materials moving beyond need animal testing. However, as with all types data knowledge today, be reusable by machines, i.e., machine-actionable, in order reach their full impact...
The adverse outcome pathways (AOPs) were developed to accelerate evidence-based chemical risk assessment by leveraging data from new approach methodologies. Thanks their stressor-agnostic approach, AOPs seen as instrumental in other fields. Here, we present that report non-chemical stressors along with the challenges encountered for development. Challenges regarding linked nanomaterials include non-specific molecular initiating events, limited understanding of nanomaterial biodistribution,...
Introduction The CIAO project was launched in Spring 2020 to address the need make sense of numerous and disparate data available on COVID-19 pathogenesis. Based a crowdsourcing model large-scale collaboration, has exploited Adverse Outcome Pathway (AOP) knowledge management framework built support chemical risk assessment driven by mechanistic understanding biological perturbations at different organizational levels. Hence AOPs might have real potential integrate produced through approaches...
Costs, scientific and ethical concerns related to animal tests for regulatory decision-making have stimulated the development of alternative methods. When applying approaches, kinetics been identified as a key element consider. Membrane transporters affect kinetic processes absorption, distribution, metabolism excretion (ADME) various compounds, such drugs or environmental chemicals. Therefore, pharmaceutical scientists intensively studied impacting drug efficacy safety. Besides...
An imbalance between primary and secondary bile acids contributes to the development of metabolic dysfunction-associated steatohepatitis (MASH). The precise mechanisms underlying changes in acid pool MASH remain be identified. As gut bacteria convert acids, we investigated contribution microbiota its metabolizing activities alterations MASH. To disentangle influence from environmental dietary factors, high fat diet fed foz/foz mice were compared their wildtype littermates. We developed...
Introduction The ingestion of nanomaterials (NMs) may impair the intestinal barrier, but underlying mechanisms remain evasive, and evidence has not been systematically gathered or produced. A mechanistic-based approach would be instrumental in assessing whether relevant NMs disrupt thereby supporting NM risk assessment food sector. Methods In this study, we developed an adverse outcome pathway (AOP) based on biological plausibility by leveraging information from existing NM-relevant AOP that...