A5089313548- Breast Lesions and Carcinomas
- Global Cancer Incidence and Screening
- MRI in cancer diagnosis
- AI in cancer detection
- Breast Cancer Treatment Studies
- Digital Radiography and Breast Imaging
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Radiation Dose and Imaging
- Radiology practices and education
- Cancer and Skin Lesions
- Artificial Intelligence in Healthcare and Education
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- COVID-19 diagnosis using AI
- Advanced X-ray and CT Imaging
- Advanced Neural Network Applications
- Climate Change and Health Impacts
- Brain Tumor Detection and Classification
- Breast Implant and Reconstruction
- Photoacoustic and Ultrasonic Imaging
- Lymphatic System and Diseases
- Takotsubo Cardiomyopathy and Associated Phenomena
- Dupuytren's Contracture and Treatments
Massachusetts General Hospital
2017-2024
Harvard University
2019-2024
University of California, San Francisco
2011-2024
Indiana University School of Medicine
2021
Indiana University – Purdue University Indianapolis
2021
University of Washington
2006-2017
Theodore Roosevelt High School
2015-2017
Brigham and Women's Hospital
2017
Seattle Cancer Care Alliance
2016
Performance of DWI as a Rapid Unenhanced Technique for Detecting Mammographically Occult Breast Cancer in Elevated-Risk Women With Dense BreastsElizabeth S. McDonald1,2, Jill A. Hammersley1, Shinn-Huey Chou1, Habib Rahbar1, John R. Scheel1, Christoph I. Lee1, Cheng-Liang Liu1, Constance D. Lehman1 and Savannah C. Partridge1Audio Available | Share
Nanoparticles of ~10 nm in diameter made with chitosan or lactic acid-grafted were developed for high drug loading and prolonged release.A encapsulation efficiency 92% a release rate 28% from nanoparticles over 4-week period demonstrated bovine serum protein.To further increase encapsulation, prolong release, solubility solution neutral pH, was modified acid by grafting D,L-lactic onto amino groups without using catalyst.The 96% protein 15% 4 weeks.With increased concentration, the decreased...
Abstract Background The development of minimally invasive, non‐viral gene delivery vehicles for the central nervous system (CNS) is an important technology goal in advancement molecular therapies neurological diseases. One approach to deliver materials peripherally that are recognized and retrogradely transported by motor neurons toward CNS. Tet1 a peptide identified Boulis coworkers possess binding characteristics tetanus toxin, which interacts specifically with undergoes fast, retrograde...
Digital tomosynthesis (DTS) of the chest is a technique whose basic components are similar to those digital radiography, but that also provides some benefits computed tomography (CT). The major advantages DTS over conventional radiography improved visibility pulmonary parenchyma and depiction abnormalities such as nodules. Calcifications, vessels, airways, wall much more readily visualized at than radiography. could potentially be combined with follow up known nodules, confirm or rule out...
The human immunodeficiency virus (HIV) and acquired syndrome (AIDS) pandemic has entered its 4th decade. Since the introduction of combination antiretroviral therapy (ART) in 1996, number AIDS-related deaths plateaued worldwide. Today, owing to effectiveness ART, HIV-infected population is aging HIV infection become a chronic illness. Non-AIDS comorbidities are increasing, spectrum HIV-related thoracic diseases evolving. In developed countries, bacterial pneumonia more common than...
Radiography, currently the standard for postoperative fracture imaging, is limited by overlapping bone and hardware. Tomosynthesis has benefit of level-by-level imaging without disadvantages metal artifacts, increased radiation, higher costs CT, current problem-solving tool. The purpose this study was to compare tomosynthesis with radiography evaluating healing.In a prospective study, patients within 1 year wrist hardware fixation underwent radiography, tomosynthesis, images were interpreted...
Background There are limited data from clinical trials describing preoperative MRI features and performance in the evaluation of mammographically detected ductal carcinoma situ (DCIS). Purpose To report qualitative DCIS, identification additional disease, associations imaging with pathologic, genomic, surgical outcomes Eastern Cooperative Oncology Group–American College Radiology Imaging Network (ECOG-ACRIN) E4112 trial. Materials Methods Secondary analyses a multicenter prospective trial...
Purpose To identify breast MR imaging biomarkers to predict histologic grade and receptor status of ductal carcinoma in situ (DCIS). Materials Methods Informed consent was waived this Health Insurance Portability Accountability Act‐compliant Institutional Review Board‐approved study. Case inclusion conducted from 7332 consecutive studies January 1, 2009, December 31, 2012. Excluding with benign diagnoses, without visible abnormal enhancement, pathology containing invasive disease yielded 55...
This paper proposes a novel U-Net variant using stacked dilated convolutions for medical image segmentation (SDU-Net). SDU-Net adopts the architecture of vanilla with modifications in encoder and decoder operations (an operation indicates all processing feature maps same resolution). Unlike which incorporates two standard each encoder/decoder operation, uses one convolution followed by multiple concatenates outputs as input to next operation. Experiments showed that outperformed U-Net,...
Shear-Wave Elastography of the Breast: Impact Technical Image Quality Parameters on Diagnostic AccuracyShinn-Huey S. Chou, MD1, Masoud Baikpour, MD1,2, Wei Zhang, MD1,2,3, Sarah F. Mercaldo, PhD1,4, Constance D. Lehman, MD, PhD1 and Anthony E. Samir, MPH1,2Audio Available | Share
Abstract US is a widely available, commonly used, and indispensable imaging modality for breast evaluation. It often the primary detection diagnosis of cancer in low-resource settings. In addition, it frequently employed as supplemental screening tool via either whole handheld or automated among women with dense breasts. recent years, variety artificial intelligence systems have been developed to assist radiologists lesions on US. This article reviews background evidence supporting use tools...
Abstract Breast density continues to be a prevailing topic in the field of breast imaging, with continued complexities contributing overall confusion and controversy among patients medical community. In this article, we explore current status cancer screening women dense breasts including legislation. Risk-based approaches supplemental may more financially cost-effective. While all advanced imaging modalities detect additional primarily invasive, node-negative cancers, degree which occurs...
Abstract Objective To determine patient sociodemographic characteristics associated with breast imaging utilization on Saturdays to inform potential initiatives designed improve access and reduce disparities in cancer care. Methods This was an IRB-approved retrospective cross-sectional study. All adult women (aged ≥18 years) who received a screening or diagnostic examination at our facility from January 1, 2016 December 31, 2017 were included. Patient including age, race, primary language,...
Data Engineering for Machine Learning in Women's Imaging and BeyondChen Cui1, Shinn-Huey S. Chou2, Laura Brattain1,3, Constance D. Lehman2 Anthony E. Samir1Audio Available | Share Claim CREDIT
The purpose of this study was to determine the performance and added value bilateral mammography in identifying cancers distant from sites presenting breast symptoms women 30-39 years old.A search identified consecutively registered old who underwent ultrasound evaluate focal between June 2006 August 2016. Outcomes were determined by imaging pathologic analysis through linkage with a tumor registry. Medical records reviewed presence cancer risk factors. Lifetime calculated International...