A5057765098- Nutrition and Health in Aging
- Colorectal Cancer Surgical Treatments
- Radiomics and Machine Learning in Medical Imaging
- Cancer Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Cancer, Lipids, and Metabolism
- Frailty in Older Adults
- COVID-19 Clinical Research Studies
- Fatty Acid Research and Health
- Colorectal Cancer Screening and Detection
- Cardiovascular Disease and Adiposity
- Nutritional Studies and Diet
- Estrogen and related hormone effects
- Multiple Myeloma Research and Treatments
- Digestive system and related health
- Gastric Cancer Management and Outcomes
- Gut microbiota and health
- Cancer Risks and Factors
- Metabolomics and Mass Spectrometry Studies
- Head and Neck Cancer Studies
- Vitamin D Research Studies
- Long-Term Effects of COVID-19
- Body Composition Measurement Techniques
- Immune cells in cancer
- IL-33, ST2, and ILC Pathways
Universidade Estadual de Campinas (UNICAMP)
2014-2025
Hospital de Clínicas da Unicamp
2010-2020
Brazilian Center for Research in Energy and Materials
2018
Universidade Federal de Minas Gerais
2015
Universidade Federal de Viçosa
2011-2013
To investigate the effect of probiotic supplementation during development an experimental model colitis associated colon cancer (CAC).C57BL/6 mice received intraperitoneal injection azoxymethane (10 mg/kg), followed by three cycles sodium dextran sulphate diluted in water (5% w/v). Probiotic group daily a mixture Lactobacillus acidophilus, rhamnosus and Bifidobacterium bifidum. Microbiota composition was assessed 16S rRNA Illumina HiSeq sequencing. Colon samples were collected for...
Abstract Patients with colorectal cancer (CRC) often exhibit changes in body composition (BC) which are associated poorer clinical outcomes. Many studies group colon and rectal cancers together, irrespective of staging, potentially affecting assessment treatment strategies. Our study aimed to compare BC patients CRC focusing on tumor location metastasis presence. A total 635 individuals were evaluated, a mean age 61.8 ± 12.4 years 50.2% female. The majority had as the primary site (51.0%),...
Patients with head and neck cancer (HNC) are at increased risk of malnutrition due to the presence tumor treatments. Body composition is a prognostic factor in these patients. However, relationship between adipose tissue characteristics survival HNC still unclear. To evaluate associations adiposity, radiodensity muscularity prognosis patients locally advanced undergoing chemoradiotherapy. This retrospective study included 132 diagnosed HNC. assessment was performed using computed tomography...
COVID-19 survivors often experience late symptoms, possibly secondary to an exacerbated inflammatory response. This study aimed investigate whether levels, assessed by the neutrophil-to-lymphocyte ratio (NLR) during hospitalization in acute phase of SARS-CoV-2 infection, affect skeletal muscle phenotype and adipose tissue outpatient follow-up after discharge. retrospective, single-center included hospitalized from March 2020 April 2021, who attended follow-ups 3 9 months Patients were...
Intestinal helminths are prevalent in individuals who live rural areas of developing countries, where obesity, type 2 diabetes, and metabolic syndrome rare. In the present study, we analyzed modulation gut microbiota mice infected with helminth Strongyloides venezuelensis, fed either a standard rodent chow diet or high-fat (HFD). To investigate effects on metabolism, expression tight-junction proteins epithelium, inflammatory markers serum tissue quantified glucose tolerance insulin...
Abstract Increased adiposity and its attendant metabolic features as well systemic inflammation have been associated with prognosis in locally advanced esophageal cancer (LAEC). However, whether myosteatosis combination inflammatory markers are of is unknown. Our study aimed to investigate the influence association on progression‐free survival (PFS) overall (OS) LAEC patients treated definitive chemoradiotherapy (dCRT). We retrospectively gathered information 123 submitted dCRT at University...
Body composition performed by computed tomography (CT) impacts on cancer patients' prognoses and responses to treatment. Myosteatosis has been related overall survival (OS) disease-specific in colorectal (CRC); however, the independent impact of association myosteatosis with prognosis colon (CC) rectal (RC) is still unclear. CT was at L3 level assess body features 227 patients CRC. Clinical parameters were collected. Overall primary outcome, secondary outcome disease-free (DFS). Skeletal...
A case-control study was conducted to assess the levels of α-tocopherol, retinol, and β-carotene in different tissues genetic expression inflammatory mediators women with breast cancer. The included 51 divided into two groups: case (n = 25) benign disease 26). We evaluated dietary intake measured plasma tissue concentrations these compounds IL-8, IL-10, IFNγ. group showed greater ingestion α-tocopherol (P 0.04) 0.011). concentration reduced 0.005). IFNγ increased by 231.0, 49.1, 57.5%,...
Breast cancer is the second most common in world, and frequent among women. Moreover, there are factors that influence risk for breast including age, genetic endocrine factors, lifestyle.To evaluate consumption of fatty acids; compare acids composition adipose tissue women with benign disease as well potential factors; describe genotypic frequency Pro12Ala PPARγ polymorphism.A hospital-based case-control study was conducted incident cases (n= 38 cancer; n= 75 disease; 166 control). Lifestyle...
Body composition abnormalities are prognostic markers in several types of cancer, including colorectal cancer (CRC). Using our data distribution on body assessments and classifications could improve clinical evaluations support population-specific opportune interventions. This study aimed to evaluate the from computed tomography assess associations with overall survival among patients CRC. In this multicenter cohort study, (N = 635) aged 18 years older CRC were observed for 12 36 months...
To determine the effects of low-dose transdermal hormone therapy (HT) on systolic (SBP) and diastolic (DBP) blood pressure (BP) evaluated by 24-h ambulatory monitoring (ABPM) in hypertensive postmenopausal women.The study was conducted 24 women aged, average, 54 years under treatment with enalapril maleate (10-20 mg/day) combined or not hydrochlorothiazide (25 mg/day). Thirteen used a adhesive containing estradiol norethisterone 125 mug active substance/day, respectively) 11 did receive HT....
We compared the relationships among percentage of body fat (%BF) and physical activity with breast cancer (BC) benign diseases (BBD) in low-income Brazilian women. A case-control study including 106 incident BC cases, 178 BBD 181 control women recruited from a public hospital-based screening center was conducted. Logistic regression models showed that sedentary have higher odds developing age adjusted model [odds ratio (OR) = 2.39, 95% confidence interval (CI) 1.43–3.99]. After adjusting for...
Abstract Inflammatory states and body composition changes are associated with a poor prognosis in many diseases, but their role coronavirus disease 2019 (COVID-19) is not fully understood. To assess the impact of low skeletal muscle radiodensity (SMD), high neutrophil-to-lymphocyte ratio (NLR) composite score based on both variables, complications, use ventilatory support, survival patients COVID-19. Medical records hospitalized between May 1, 2020, July 31, laboratory diagnosis COVID-19 who...
We aim to verify the use of ML algorithms predict patient outcome using a relatively small dataset and create nomogram assess in-hospital mortality patients with COVID-19.A database 200 COVID-19 admitted Clinical Hospital State University Campinas (UNICAMP) was used in this analysis. Patient features were divided into three categories: clinical, chest abnormalities, body composition characteristics acquired by computerized tomography. These evaluated independently combined outcomes. To...
Hyaluronic Acid-binding protein 4 (HABP4) is a regulatory of 57 kDa that functionally involved in transcription regulation and RNA metabolism shows several characteristics common to oncoproteins or tumor suppressors, including altered expression cancer tissues, nucleus/cytoplasm shuttling, intrinsic lack structure, complex interactomes post translational modifications. Its gene has been found region on chromosome 9q22.3-31, which contains SNP haplotypes occurring individuals with high risk...
In epidemiological studies, higher calcium intake has been associated with decreased colorectal cancer (CRC) incidence. However, whether circulating concentrations are CRC prognosis is largely unknown. this retrospective cohort analysis, we identified 498 patients diagnosed stage I-IV between the years of 2000 and 2018 in whom albumin level measurements within 3 months diagnosis had taken. We used Kaplan-Meier method for survival analysis. multivariate Cox proportional hazards regression to...