A5067117267- Nutrition and Health in Aging
- Inflammatory Biomarkers in Disease Prognosis
- Childhood Cancer Survivors' Quality of Life
- Frailty in Older Adults
- Antioxidant Activity and Oxidative Stress
- Biochemical effects in animals
- Fatty Acid Research and Health
- Enhanced Recovery After Surgery
- Head and Neck Cancer Studies
- Diet and metabolism studies
- Glioma Diagnosis and Treatment
- Science and Education Research
- Cancer, Lipids, and Metabolism
- COVID-19 and healthcare impacts
- Free Radicals and Antioxidants
- Cholesterol and Lipid Metabolism
- Body Composition Measurement Techniques
- Adipose Tissue and Metabolism
- Cancer survivorship and care
- Dysphagia Assessment and Management
- Medical Imaging Techniques and Applications
- Coenzyme Q10 studies and effects
- Vitamin K Research Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer, Stress, Anesthesia, and Immune Response
Instituto Nacional do Câncer
2017-2024
Hospital do Câncer III
2019-2024
Instituto Nacional del Cáncer
2022
Universidade Federal do Rio de Janeiro
2007-2016
Universidade Federal do Estado do Rio de Janeiro
2011-2015
Consorzio Interuniversitario Nazionale La Chimica Per L'Ambiente
2012
In-Q-Tel
2011
Background: Neutrophil-lymphocyte ratio (NLR) and nutritional status may provide a prognostic value in colorectal cancer (CRC). Thus, aim of this study was to evaluate the NLR CRC patients.Methods: A retrospective analysis conducted patients. The independent variables were body mass index (BMI), weight loss (WL) NLR. Logistic regression used estimate odds chance low Kaplan-Meier curves Cox overall survival at 5 years old.Results: In 148 patients evaluated, most prevalent overweight/obesity...
Abstract The objective of the present study was to evaluate effect probiotic VSL#3 isolated or associated with a yacon‐based product (synbiotic) on oxidative stress modulation and intestinal permeability in an experimental model colorectal carcinogenesis. Forty‐five C57BL/6J mice were divided into three groups: control (standard diet AIN‐93 M); M multispecies VSL#3, 2.25 × 10 9 CFU), synbiotic product, 6% fructooligosaccharides inulin, CFU). diets provided for 13 weeks. showed antioxidant...
BackgroundColorectal cancer (CRC) is responsible for the second leading cause of death worldwide. Thus, aim this study was to investigate application a new nutritional status and inflammatory tool predict overall survival (OS) in patients with CRC preoperative period.MethodsRetrospective cohort both sexes treated at hospital unit, aged ≥20 years. Data were extracted between 2007 2015. Multivariate Cox's models employed OS utilizing grade classification system (body mass index vs. percentage...
Body composition abnormalities are prognostic markers in several types of cancer, including colorectal cancer (CRC). Using our data distribution on body assessments and classifications could improve clinical evaluations support population-specific opportune interventions. This study aimed to evaluate the from computed tomography assess associations with overall survival among patients CRC. In this multicenter cohort study, (N = 635) aged 18 years older CRC were observed for 12 36 months...
Abstract The effects of radiation are known to be potentiated by N‐3 polyunsaturated fatty acids, which modulate several signaling pathways, but the molecular mechanisms through these acids enhance anticancer irradiation in colorectal cancer (CRC) treatment remain poorly elucidated. Here, we aimed ascertain whether acid docosahexaenoic (DHA) exerts a modulating effect on response elicited (RT). Two CRC cell lines, Caco‐2 and HT‐29, were exposed RT, DHA, or both (DHA + RT) for various times,...
Strokes are preceded by oxidative stress and inflammation, two processes linked to atherosclerosis hypertension. Statins have been widely employed control atherosclerosis; however, there could be neurological implications its use—including cognitive impairment. Thus, we aimed determine whether alpha-tocopherol is capable of reversing the side effects statins enhancing anti-inflammatory properties. To assess these effects, 15-week-old stroke-prone spontaneously hypertensive rats (SHRSPs) were...
Background Surgery has become the treatment of choice for head and neck cancer (HNC) in most cases. Preoperative fasting abbreviation nutrition screening have been suggested to reduce occurrence postoperative complications. This study aimed evaluate addition whey protein preoperative analyze association status on complications patients with HNC. Methods A randomized, single‐blind clinical trial was performed. Patients recruited from March November 2018 at a national reference center Brazil...
Abstract Decylubiquinone treatment in vitro has demonstrated a potent inhibitor effect on reactive oxidative species production. However, the vivo not been yet. Thus, rats SHRSP male were divided two groups: treated and controls ( n = 6, each). The group received 10 mg/Kg − /body weight of decylubiquinone diluted coconut oil by oral gavage during four weeks. Control just vehicle. Body weight, diuresis, food water intake, systolic blood pressure, total cholesterol, LDL‐cholesterol,...
Laryngeal squamous cell carcinoma (LSCC) is a frequent cancer subtype among head and neck cancers. Exacerbated inflammation nutritional deficit are common features in this type of can be used as prognostic marker. This study aimed to investigate the relationship between body mass index (BMI), neutrophil-to-lymphocyte ratio (NLR), systemic response (SIRI) on overall survival (OS) LSCC patients. In retrospective cohort study, 168 patients were followed for 5 years. Data clinical factors,...
To identify factors associated with referral to an exclusive palliative care unit (PCU) in patients colorectal cancer (CRC).Retrospective cohort study having CRC of both sexes treated at a hospital unit, aged ≥20 years. Data were extracted from the medical records pretreatment between January 2008 and August 2014. The outcome was PCU within 5 Logistic regression analyses performed assess whether sociodemographic, clinical, nutritional, biochemistry data referral, generating odds ratios (OR),...
Cerebrovascular disease studies have shown similarity between humans and spontaneously hypertensive rats stroke-prone in the development of spontaneous stroke transitory ischemic attacks (TIA). In addition, nitric oxide (NO) suppression by L-arginine methyl ester (L-NAME) can precipitate several vascular diseases including TIA strokes. On other hand, alpha-tocopherol (AT) has been associated with beneficial effects on disorders. Four groups were tested to evaluate AT NO inhibition: AT,...
This study aimed to evaluate the prognostic value of thigh muscle assessed by CT images predict overall mortality in patients with colorectal cancer (CRC). was a multicenter cohort including adults (≥ 18 years old) newly diagnosed CRC, who performed diagnostic computed tomography (CT) exam regions. were analyzed skeletal (SM cm2), index (SMI cm2/m2), and density (SMD HU). Muscle abnormalities (low SM, SMI, SMD) defined as values below median sex. Kaplan–Meyer curves hazard ratios (HRs) for...
Introdução: A leucemia linfoblástica aguda (LLA ) constitui a neoplasia mais comum em pediatria e avaliação nutricional é um instrumento essencial para conhecer as condições de saúde dos pacientes. O presente estudo teve como objetivo avaliar descrever o estado pacientes pediátricos recém-diagnosticados com LLA verificar relação do índice massa corporal idade (IMC/I) demais medidas antropométricas. Método: Estudo observacional, transversal, realizado 1 18 anos, , no período janeiro/2004...
A number of risk factors have been associated to the stroke and many strategies proposed in order control them as well. Vitamin K has largely found brain, which suggests a possible function at that tissue. This study aimed evaluate potential this vitamin on prevention cognitive SHRSP rats. Twelve males, 15 weeks old, were divided into two groups (n= 6 each), receiving vehicle-coconut oil (control group) or 40 μg phylloquinone (treated during 28 days. Biological parameters, systolic blood...
Introdução: A leucemia linfoblástica aguda é a neoplasia mais comum na população pediátrica, e estudos apontam o estado nutricional como um fator prognóstico importante. Objetivo: Avaliar de uma coorte crianças adolescentes durante tratamento para aguda, determinar sua associação com risco recaída sobrevida em cinco anos seguimento. Método: Estudo observacional, retrospectivo, 54 pacientes 1 18 tratados hospital referência oncologia, entre janeiro 2004 dezembro 2009. Os dados antropométricos...
Background: Central nervous system tumors (CNS) are the second most common malignancies in childhood. Inflammation and changes nutritional status play an important role can be used as prognostic markers. Thus, this study aimed to evaluate predictive ability of inflammatory markers on overall survival (OS) pediatric patients with CNS. Methods: In retrospective cohort study, 103 were followed for 1, 3, 5 years. Clinical, anthropometric, hematological data collected. Body mass index age...