A5033944308- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Cancer Cells and Metastasis
- Barrier Structure and Function Studies
- Glycosylation and Glycoproteins Research
- Wnt/β-catenin signaling in development and cancer
- Genetic factors in colorectal cancer
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related molecular mechanisms research
- Insect Pest Control Strategies
- Galectins and Cancer Biology
- Cancer Research and Treatments
- Cancer-related Molecular Pathways
- Phytochemistry Medicinal Plant Applications
- Cell Adhesion Molecules Research
- S100 Proteins and Annexins
- Neurological Disease Mechanisms and Treatments
- Hippo pathway signaling and YAP/TAZ
- Cellular Mechanics and Interactions
- Sesquiterpenes and Asteraceae Studies
- Colorectal Cancer Treatments and Studies
- Cancer, Hypoxia, and Metabolism
- Cytokine Signaling Pathways and Interactions
- MicroRNA in disease regulation
- TGF-β signaling in diseases
Instituto Nacional do Câncer
2015-2024
Universidade Estadual de Campinas (UNICAMP)
2023
Universidade Federal do Maranhão
2023
Military Institute of Engineering
2023
University of Hradec Králové
2023
Fundação CECIERJ
2023
Centro Universitário da Cidade
2023
Instituto Nacional de Metrologia, Qualidade e Tecnologia
2019
Universidade Federal do Rio de Janeiro
2014-2017
National Cancer Institute
2008-2015
Lipid bodies (lipid droplets) are emerging as dynamic organelles involved in lipid metabolism and inflammation. Increased body numbers have been described tumor cells; however, its functional significance cancer has never addressed. Here, we showed increased number of tissues from patients with adenocarcinoma colon submitted to surgical resection when compared an adjacent normal tissue. Accordingly, were observed human cell lines a H-rasV12-transformed intestinal epithelial line (IEC-6...
The metastatic process in breast cancer is related to the expression of epithelial-to-mesenchymal transition transcription factors (EMT-TFs) SNAIL, SLUG, SIP1 and TWIST1. EMT-TFs nuclear factor-κB (NF-κB) activation have been associated with aggressiveness potential carcinomas. Here, we sought examine role NF-κB aggressive properties regulation human cells. Blocking NF-κB/p65 activity by reducing its transcript protein levels (through siRNA-strategy dehydroxymethylepoxyquinomicin [DHMEQ]...
The in vitro activity of parthenolide against Leishmania amazonensis was investigated. Parthenolide is a sesquiterpene lactone purified from the hydroalcoholic extract aerial parts Tanacetum parthenium. This isolated compound identified through spectral analyses by UV, infrared, (1)H and (13)C nuclear magnetic resonance imaging, DEPT (distortionless enhancement polarization transfer), COSY (correlated spectroscopy), HMQC (heteronuclear multiple-quantum coherence), electron spray...
Abstract Hyperglycemia is a common feature of diabetes mellitus, considered as risk factor for cancer. However, its direct effects in cancer cell behavior are relatively unexplored. Herein we show that high glucose concentration induces aberrant glycosylation, increased proliferation, invasion and tumor progression colon By modulating the activity rate-limiting enzyme, glutamine-fructose-6-phosphate amidotransferase (GFAT), demonstrate hexosamine biosynthetic pathway (HBP) involved those...
The PI3K/Akt and Wnt/β-catenin pathways play an important role in the acquisition of malignant phenotype cancer. However, there are few data regarding interplay between both colorectal cancer (CRC) progression. mutational status clinicopathological characteristics were accessed by bioinformatic analysis whereas that impact activity to explain tumorigenic potential was performed vitro using IGF-1 Wnt3a treatments CRC cell models. these did not influence survival patients, but association...
In colorectal cancer tight junction molecular and morphological alterations are poorly understood. this study, adenocarcinoma tissues their paired normal mucosa ( n = 12) were analyzed for molecular. The expression of claudin‐1, ‐3 ‐4 was upregulated 5.7‐, 1.5‐ 2.4‐fold, respectively, in tumor comparison to the ones. Although remains cancerous epithelium, its barrier function altered. Despite claudins overexpression, paracellular permeability ruthenium red increased a significant...
Annexin A2 (ANXA2) is upregulated in several malignancies, including colorectal cancer (CRC). However, there little knowledge on the molecular mechanisms involved to its upregulation. The aim of this study was identify mechanism through which ANXA2 overexpression leads CRC progression and evaluate potential prognostic value. We used human samples analyse correlation between levels tumour staging. expression increased tissues compared normal colon tissues. In addition, we observe stage IV...
Investigation of the mode action naphthoimidazole N1, obtained from reaction beta-lapachone with benzaldehyde, which among 45 semi-synthetic derivatives naphthoquinones isolated Tabebuia sp. was one most active compounds against Trypanosoma cruzi trypomastigotes.Quantification effect N1 proliferative forms T. cruzi, and investigation potential targets in parasite using electron microscopy flow cytometry techniques.N1 presented following order activity: amastigotes > trypomastigotes...
Euterpe oleracea Mart., a plant from the Amazon region, is commonly known as açaí or juçara; it has high nutritional value and elevated levels of lipids, proteins, minerals. Açaí an abundant much consumed fruit by local population, studies have demonstrated that rich in phytochemicals with antioxidant, anti-inflammatory, anticancer activities. Therefore, aim this study was to test for activity different human malignant cell lines. Cell lines derived breast colorectal adenocarcinomas were...
ABSTRACT Radiotherapy remains a major approach to adjuvant therapy for patients with advanced colorectal cancer, however, the fractionation schedules frequently allow repopulation of surviving tumors cells, neoplastic progression, and subsequent metastasis. The aim present study was analyze transgenerational effects induced by radiation evaluate whether it could increase malignant features on progeny derived from irradiated parental cancer Caco‐2, HT‐29, HCT‐116. these cells displayed...
The altered expressions of claudin proteins have been reported during the tumorigenesis colorectal cancer. However, molecular mechanisms that regulate these events in this cancer type are poorly understood. Here, we report epidermal growth factor (EGF) increases expression claudin-3 human adenocarcinoma HT-29 cells. This increase was related to increased cell migration and formation anchorage-dependent anchorage-independent colonies. We further showed ERK1/2 PI3K-Akt pathways were involved...
The participation of oxidative stress in the mechanism metformin action breast cancer remains unclear. We investigated effects clinical (6 and 30 μM) experimental concentrations (1000 5000 MCF-7 MDA-MB-231 cells, verifying cytotoxicity, stress, DNA damage, intracellular pathways related to cell growth survival after 24 h drug exposure. Clinical decreased metabolic activity cells MTT assay, which showed increased although death impairment proliferative capacity were observed only at higher...
Citral is a natural compound that has shown cytotoxic and antiproliferative effects on breast hematopoietic cancer cells; however, there are few studies melanoma cells. Oxidative stress known to be involved in all stages of development able modulate intracellular pathways related cellular proliferation death. In this study, we hypothesize citral exerts its effect cells by the modulation oxidative status and/or signaling. To test hypothesis, investigated B16F10 murine evaluating stress, DNA...
Lithium is a well-established non-competitive inhibitor of glycogen synthase kinase-3β (GSK-3β), kinase that involved in several cellular processes related to cancer progression. GSK-3β regulated upstream by PI3K/Akt, which negatively modulated PTEN. The role lithium plays controversial because can activate or inhibit survival signaling pathways depending on the cell type. In this study, we analyzed mechanisms modulate events colorectal (CRC) progression and evaluated such as PI3K/Akt PTEN...