A5082338881- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Regulation of Appetite and Obesity
- Retinal Development and Disorders
- Adipose Tissue and Metabolism
- Growth Hormone and Insulin-like Growth Factors
- Neurobiology and Insect Physiology Research
- Neuroendocrine regulation and behavior
- Alzheimer's disease research and treatments
- Urological Disorders and Treatments
- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
Boston VA Research Institute
2020-2024
Harvard University
2020-2024
Boston Children's Hospital
2020-2024
University of California, Los Angeles
2019
Chinese University of Hong Kong
2004-2012
Bladder exstrophy epispadias complex (BEEC) is a severe congenital anomaly; however, the genetic and molecular mechanisms underlying formation of BEEC remain unclear. TP63, member TP53 tumor suppressor gene family, expressed in bladder urothelium skin over external genitalia during mammalian development. It plays role We have previously shown that p63(-/-) mouse embryos developed phenotype identical to human BEEC. hypothesised TP63 involved pathogenesis. RNA was extracted from foreskin...
Significance Hunger regulates many animal behaviors. In particular, some chemosensory stimuli can be attractive or repulsive depending on the feeding state of an animal. The neural basis for hunger-dependent changes in valence is poorly understood. Here, we show that response Caenorhabditis elegans to CO 2 depends hunger. shifts from during starvation. This change results modulation circuit by opposing biogenic amine signals. Dopamine promotes repulsion well-fed animals, whereas octopamine...
Apical extracellular matrix (aECM) constitutes the interface between every tissue and outside world. It is patterned into diverse tissue-specific structures through unknown mechanisms. Here, we show that a male-specific genetic switch in single C. elegans glial cell patterns overlying aECM from solid sheet to an ∼200 nm pore, thus allowing male sensory neuron access environment. Using cell-specific sex reversal, find this reflects inherent difference independent of identity surrounding...
Glia shape the development and function of C. elegans nervous system, especially its sense organs central neuropil (nerve ring). Cell-type-specific promoters allow investigators to label or manipulate individual glial cell types, therefore provide a key tool for deciphering function. In this technical resource, we compare specificity, brightness, consistency cell-type-specific glia. We identify set study seven types (F16F9.3, amphid phasmid sheath glia; F11C7.2, glia only; grl-2, socket...
Apical extracellular matrix (aECM) constitutes the interface between every tissue and outside world. It is patterned into diverse tissue-specific structures through unknown mechanisms. Here, we show that a male-specific genetic switch in single C. elegans glial cell patterns aECM ∼200 nm pore, allowing male sensory neuron to access environment. We find this sex difference controlled by factors shared with neurons ( mab-3, lep-2, lep-5 ) as well previously unidentified regulators whose...
ABSTRACT Glia shape the development and function of C. elegans nervous system, especially its sense organs central neuropil (nerve ring). Cell-type-specific promoters allow investigators to label or manipulate individual glial cell types, therefore provide a key tool for deciphering function. In this technical resource, we compare specificity, brightness, consistency cell-type-specific glia. We identify set study seven types ( F16F9.3 , amphid phasmid sheath glia; F11C7.2 glia only; grl-2...