A5015773853- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
- Parkinson's Disease Mechanisms and Treatments
- Colorectal and Anal Carcinomas
- Cardiac, Anesthesia and Surgical Outcomes
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Trace Elements in Health
- Urological Disorders and Treatments
- Nuclear Receptors and Signaling
- Alzheimer's disease research and treatments
- Heavy Metal Exposure and Toxicity
- Enhanced Recovery After Surgery
- Bladder and Urothelial Cancer Treatments
- Cancer Genomics and Diagnostics
- Second Language Learning and Teaching
- Neuroscience and Neuropharmacology Research
- EFL/ESL Teaching and Learning
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Invertebrate Immune Response Mechanisms
- Cancer Immunotherapy and Biomarkers
- Anorectal Disease Treatments and Outcomes
- Ocular Surface and Contact Lens
- Malaria Research and Control
Cabrini Hospital
2014-2024
Monash University
2015-2024
Royal Devon & Exeter NHS Foundation Trust
2024
Australia and New Zealand Banking Group
2023
Florey Institute of Neuroscience and Mental Health
2017-2021
The University of Melbourne
2006-2021
Alfred Health
2016
Malvern Community Hospital
2015
Maimonides Medical Center
2015
Monash Institute of Medical Research
2010-2013
Parkinson’s disease (PD) is a progressive, chronic characterized by dyskinesia, rigidity, instability, and tremors. The defined the presence of Lewy bodies, which primarily consist aggregated α-synuclein protein, accompanied loss monoaminergic neurons. Current therapeutic strategies only give symptomatic relief motor impairment do not address underlying neurodegeneration. Hence, we have identified CuII(atsm) as potential for PD. Drug administration to four different animal models PD resulted...
Significance Clostridioides difficile is the most common cause of hospital-acquired diarrhea. It responsible for more than half all hospital enteric infections and >90% mortalities resulting from these infections. Gut damage sustained during C. infection devastating, inducing epithelial deep into gut tissue, to regions where stem cells tissue repair reside. Our work has shown that toxin-mediated severe murine alters colonic protective barrier, which promotes cell dysfunction, exacerbating...
This study demonstrates the application of quantitative elemental bio-imaging for determination distribution Cu, Mn, Fe and Zn in Parkinsonism mouse model brains. Elevated concentrations these metals within substantia nigra (SN) are suspected to play a role on development Parkinson's disease. Elemental employs laser ablation inductively coupled mass spectrometry (LA-ICP-MS) construct images trace element distribution. Quantitative data was produced by ablating standard tissue sections...
Bladder exstrophy epispadias complex (BEEC) is a severe congenital anomaly; however, the genetic and molecular mechanisms underlying formation of BEEC remain unclear. TP63, member TP53 tumor suppressor gene family, expressed in bladder urothelium skin over external genitalia during mammalian development. It plays role We have previously shown that p63(-/-) mouse embryos developed phenotype identical to human BEEC. hypothesised TP63 involved pathogenesis. RNA was extracted from foreskin...
Abstract Elevated iron in the SNpc may play a key role Parkinson’s disease (PD) neurodegeneration since drug candidates with high affinity rescue PD animal models, and one candidate, deferirpone, has shown efficacy recently phase two clinical trial. However, strong chelators perturb essential metabolism, it is not yet known whether damage associated mediated by tightly bound (eg ferritin) or lower-affinity, labile, pool. Here we report preclinical characterization of PBT434, novel...
Elemental bio-imaging using the technological advances of ICP-QQQ-MS.
By the time a patient first presents with symptoms of Parkinsons disease at clinic, significant proportion (50-70%) cells in substantia nigra (SN) has already been destroyed. This degeneration progresses until, within few years, most have died. Except for rare cases familial PD, initial trigger cell loss is unknown. However, we do some clues as to why damage, once initiated, unabated. It would represent major advance therapy arrest stage when clinic. Current therapies focus on relieving...
Three dimensional maps of iron (Fe), zinc (Zn), copper (Cu), manganese (Mn) and phosphorous (P) in a 6-hydroxydopamine (6-OHDA) lesioned mouse brain were constructed employing novel quantitative laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) imaging method known as elemental bio-imaging. The 3D produced by ablating serial consecutive sections taken from the same animal. Each section was quantified against tissue standards resulting three map that represents variation...
Abstract Aim Obesity is common in Western countries and its prevalence increasing. Colorectal cancer common, surgery for colorectal technically more challenging obese patients. Laparoscopic colon has been shown to be oncologically equivalent, with improved short‐ term outcomes. rectal proven challenging, recent results have raised concerns about oncological equivalence. Our aim was evaluate the effect of body mass index ( BMI ) on clinical outcomes cancer, including rate at which...
Abstract Right-sided colon cancer (RCC) and left-sided (LCC) differ in features outcomes because of variations embryology, epidemiology, pathology, prognosis. This study sought to identify significant factors impacting patient survival through Bayesian modelling. Data was retrospectively analysed from a colorectal neoplasia database. on demographics, perioperative risks, treatment, mortality, patients who underwent surgery January 2010 December 2021. involved 2475 patients, with 58.7% having...
Lymph node yield (LNY) of 12 or more in resection colorectal cancer is recommended current international guidelines. Although a low LNY (less than 12) associated with poorer outcome some studies, its prognostic value unclear patients early-stage rectal complete pathological response following neoadjuvant therapy. ratio (LNR), which reflects the proportion positive to total nodes obtained, may be accurate predicting stage III cancer. This study aimed identify factors correlating and evaluate...
Abstract Background Globally, colorectal cancer (CRC) is the third and second leading in men women respectively with 600,000 deaths per year. Traditionally, clinicians have relied solely on nodal disease involvement, measurements such as lymph node ratio (LNR; of metastatic/positive nodes to total number examined), when determining patient prognosis CRC. The log odds positive (LODDS) a logistic transformation formula that uses pathologic data stratify survival differences among patients...
Abstract Previously genome-wide association methods in patients with classic bladder exstrophy (CBE) found ISL1 , a master control gene expressed pericloacal mesenchyme. This study sought to further explore the genetics larger set of following-up on most promising genomic regions previously reported. Genotypes 12 markers obtained from 268 CBE Australian, British, German Italian, Spanish and Swedish origin 1,354 ethnically matched controls 92 case-parent trios North America were analysed....
Surgery in the very elderly is a topic that has not been well studied, despite steady rise this population. With population, there now discussion on safety of surgery cohort for colorectal cancer.The purpose study was to investigate elective and nonelective cancer outcomes patients aged ≥90 years at both private public hospitals Melbourne, Victoria, Australia.This retrospective analysis who were included prospectively maintained Cabrini Monash University Department neoplasia database entered...
There are approximately 1.3 million patients in Australia with diabetes. Conflicting reports exist the literature as to effect of diabetes on outcomes colorectal cancer patients. We hypothesized that would have poorer perioperative outcomes, and was an independent risk factor for both 30-day mortality morbidity. The aim this study assess impact surgery compared a diabetes-free reference population, examine factors affecting risk. conducted analysis prospectively collected, clinician-led...
Colorectal cancer (CRC) is the second leading cause of death worldwide. To improve outcomes for these patients, we need to develop new treatment strategies. Personalized medicine, where patients are treated based on characteristics their own tumor, has gained significant interest its promise and reduce unnecessary side effects. The purpose this study was examine potential utility patient-derived colorectal organoids (PDCOs) in a personalized medicine setting.
BACKGROUND: Many studies have shown significantly improved outcomes (reduced local recurrence and overall survival) for patients achieving a complete pathological response from neoadjuvant chemoradiotherapy. OBJECTIVE: This study aimed to document the rate in receiving preoperative long-course chemoradiotherapy stratified extent of T3 mesorectal invasion measured on imaging. DESIGN: is retrospective prospectively collected data, with rectal cancer Cabrini Monash University Department Surgery...
In 2019, in Australia, there were 500,000 people aged 85 and over. Traditionally, clinicians have adopted the view that surgery is not desirable this cohort due to increasing perioperative risk, perceived minimal clinical benefit, shortened life expectancy. This study aimed at investigating postoperative outcomes from elective non-elective colorectal cancer patients 80 over.A retrospective analysis was conducted on 2010 2020 a prospectively maintained database. Patients over who underwent...