A5011050771- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Hepatitis Viruses Studies and Epidemiology
- Viral gastroenteritis research and epidemiology
- HIV Research and Treatment
- Protein Degradation and Inhibitors
- Metabolism and Genetic Disorders
- Cancer, Lipids, and Metabolism
- vaccines and immunoinformatics approaches
- Viral Infections and Outbreaks Research
- Hepatocellular Carcinoma Treatment and Prognosis
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2025
Unité de Nutrition Humaine
2021-2025
Centre Hospitalier Universitaire de Clermont-Ferrand
2022
Centre de Recherche en Cancérologie de Lyon
2015-2020
Inserm
2016-2020
Centre National de la Recherche Scientifique
2016-2020
Université Claude Bernard Lyon 1
2016
ABSTRACT Background and Aims Metabolic dysfunction‐associated steatotic liver disease (MASLD) is the most common cause of hepatocellular carcinoma (HCC). In this study, we combine metabolomic gene expression analysis to compare HCC tissues with non‐tumoural (NTT). Methods A non‐targeted strategy LC–MS was applied 52 pairs human MASLD‐HCC NTT separated into 2 groups according fibrosis severity F0F1‐F2 versus F3F4. The genes related de Novo lipogenesis (DNL) fatty acid oxidation (FAO) has been...
Hepatitis delta virus (HDV) increases morbidity in B (HBV)-infected patients. In the mid-eighties, an outbreak of HDV fulminant hepatitis (FH) Central African Republic (CAR) killed 88% patients hospitalized Bangui. We evaluated infections with HBV and among students pregnant women, 25 years after to determine (i) prevalence infection this population, (ii) clinical risk factors for and/or infections, (iii) characterize compare strains from FH 1980s 2010 HBV–HDV strains. performed a cross...
Non-Alcoholic Fatty Liver Disease (NAFLD) is considered as the forthcoming predominant cause for hepatocellular carcinoma (HCC). NAFLD-HCC may rise in non-cirrhotic livers 40 to 50% of patients. The aim this study was identify different metabolic pathways HCC according fibrosis level (F0F1 vs. F3F4). A non-targeted metabolomics strategy applied. We analyzed 52 pairs human and adjacent non-tumoral tissues which included 26 developed severe or cirrhosis (F3F4) no mild (F0F1). Tissue extracts...
Hepatitis Delta virus (HDV) is a satellite of B with single-stranded circular RNA genome. HDV genome synthesis carried out in infected cells by cellular polymerases the assistance small hepatitis delta antigen (S-HDAg). Here we show that S-HDAg binds bromodomain (BRD) adjacent to zinc finger domain 2B (BAZ2B) protein, regulatory subunit BAZ2B-associated remodeling factor (BRF) ISWI chromatin complexes. shRNA-mediated silencing BAZ2B or its inactivation BRD inhibitor GSK2801 impairs...