A5102860604- RNA modifications and cancer
- Hepatitis B Virus Studies
- Epigenetics and DNA Methylation
- Hepatitis C virus research
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immune responses and vaccinations
- RNA Interference and Gene Delivery
- Mycobacterium research and diagnosis
- MicroRNA in disease regulation
- Gut microbiota and health
- Melanoma and MAPK Pathways
- Connective tissue disorders research
- HIV/AIDS drug development and treatment
- Heme Oxygenase-1 and Carbon Monoxide
- Metabolomics and Mass Spectrometry Studies
- Cancer, Lipids, and Metabolism
- Chronic Lymphocytic Leukemia Research
- Pancreatic and Hepatic Oncology Research
- Ubiquitin and proteasome pathways
Centre de Recherche en Cancérologie de Lyon
2024-2025
Inserm
2009-2025
Centre National de la Recherche Scientifique
2024-2025
Sapienza University of Rome
2014-2015
Italian Institute of Technology
2015
Charité - Universitätsmedizin Berlin
2009
Fondazione Andrea Cesalpino
2009
Besides suppressing immune responses, regulatory T cells (Tregs) maintain tissue homeostasis and control systemic metabolism. Whether iron is involved in Treg-mediated tolerance completely unknown. Here, we showed that the transferrin receptor CD71 was upregulated on activated Tregs infiltrating human liver cancer. Mice with a Treg-restricted deficiency spontaneously developed scurfy-like disease, caused by impaired perinatal Treg expansion. CD71-null displayed decreased proliferation...
ABSTRACT Background and Aims Metabolic dysfunction‐associated steatotic liver disease (MASLD) is the most common cause of hepatocellular carcinoma (HCC). In this study, we combine metabolomic gene expression analysis to compare HCC tissues with non‐tumoural (NTT). Methods A non‐targeted strategy LC–MS was applied 52 pairs human MASLD‐HCC NTT separated into 2 groups according fibrosis severity F0F1‐F2 versus F3F4. The genes related de Novo lipogenesis (DNL) fatty acid oxidation (FAO) has been...