A5003011523- Chromosomal and Genetic Variations
- CRISPR and Genetic Engineering
- Genomics and Phylogenetic Studies
- RNA and protein synthesis mechanisms
- HIV Research and Treatment
- Animal Disease Management and Epidemiology
- RNA Interference and Gene Delivery
- Gut microbiota and health
- T-cell and Retrovirus Studies
- Respiratory and Cough-Related Research
- Signaling Pathways in Disease
- Ear Surgery and Otitis Media
- T-cell and B-cell Immunology
- Genetics and Neurodevelopmental Disorders
- Pluripotent Stem Cells Research
- Toxin Mechanisms and Immunotoxins
- Birth, Development, and Health
- Animal Genetics and Reproduction
- Immune cells in cancer
- Antimicrobial Resistance in Staphylococcus
- Advanced biosensing and bioanalysis techniques
- Neuroendocrine regulation and behavior
- Tryptophan and brain disorders
- Viral Infections and Immunology Research
- Monoclonal and Polyclonal Antibodies Research
European Molecular Biology Laboratory
2018-2024
University of Rome Tor Vergata
2015-2023
Abstract The gut microbiota operates at the interface of host–environment interactions to influence human homoeostasis and metabolic networks 1–4 . Environmental factors that unbalance microbial ecosystems can therefore shape physiological disease-associated responses across somatic tissues 5–9 However, systemic impact microbiome on germline—and consequently F 1 offspring it gives rise to—is unexplored 10 Here we show act as a key between paternal preconception environment intergenerational...
Human endogenous retroviruses (HERVs) have been implicated in human physiology and pathology. A better knowledge of the retroviral transcriptional activity general population during life span would greatly help debate on its pathologic potential. The four HERV families (H, K, W, E) was assessed, by qualitative quantitative PCR, PBMCs from 261 individuals aged 1 to 80 years. Our results show that HERV-H, HERV-K, HERV-W, but not HERV-E, are transcriptionally active test already early...
Melanoma is a heterogeneous tumor in which phenotype-switching and CD133 marker have been associated with metastasis promotion chemotherapy resistance. positive (CD133+) subpopulation has also suggested as putative cancer stem cell (CSC) of melanoma tumor. Human endogenous retrovirus type K (HERV-K) described to be aberrantly activated during progression implicated the etiopathogenesis disease. Earlier, we reported that stress-induced HERV-K activation promotes malignant transformation...
Antibiotic resistance is an increasingly serious threat to human health that needs urgent action. The aim of this study was determine the prevalence and antibiotic susceptibility profiles bacteria isolated from patient ear discharges suspected otitis media. A retrospective analysis performed using culture test results 1225 patients who visited Dessie Regional Health Research Laboratory 2001 2011. Results showed a strong association (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
The Autism Spectrum Disorder (ASD) is a heterogeneous group of neurodevelopmental disorders, clinically diagnosed since the lack reliable biomarkers. aetiology probably attributable to combination genetic vulnerability and environmental factors, recently, maternal immune activation has been linked derailed neurodevelopment, resulting in ASD offspring. Human endogenous retroviruses (HERVs) are relics ancestral infections, integrated human DNA. Given HERV persistence genome, some HERVs have...
Abstract Retroelements, such as Human Endogenous Retroviruses (HERVs), have been implicated in many complex diseases, including neurological and neuropsychiatric disorders. Previously, we demonstrated a distinctive expression profile of specific HERV families peripheral blood mononuclear cells from Autistic Spectrum Disorders (ASD) patients, suggesting their involvement ASD. Here used two distinct ASD mouse models: inbred BTBR T+tf/J mice CD-1 outbred prenatally exposed to valproic acid....
Abnormal activation of human endogenous retroviruses (HERVs) has been associated with several diseases such as cancer, autoimmunity, and neurological disorders. In particular, in cancer HERV activity expression have specifically tumor aggressiveness patient outcomes. Cancer cell is intimately linked to the acquisition peculiar plasticity heterogeneity based on stemness features, well crosstalk between cells microenvironment. The latter a driving factor aggressive phenotypes, metastasis...
Background: Thymosin alpha 1 (Tα1) is a well-recognized immune response modulator in wide range of disorders, particularly infections and cancer. The bioinformatic analysis public databases allows drug repositioning, predicting new potential area clinical intervention. We aimed to decipher the cellular network induced by Tα1 treatment confirm present use identify applications.Research design methods: used transcriptional profile human peripheral blood mononuclear cells treated vitro with...
Abstract Background: Malignant melanoma is one of the most aggressive types skin cancers and its etiology not yet clear. Phenotypic-switching has been associated with tumor aggressiveness metastasis. Microenvironmental factors such as estrogen, cytokines other stress conditions determine epigenetic events, hypo-methylation, which are involved in cell transformation. Interestingly, endogenous retroviruses contribute to progression transcriptionally regulated by events. Previously, we...