A5083691357- Prostate Cancer Diagnosis and Treatment
- Urinary Bladder and Prostate Research
- Radiopharmaceutical Chemistry and Applications
- Renal cell carcinoma treatment
- Chromosomal and Genetic Variations
- CRISPR and Genetic Engineering
- Pediatric Urology and Nephrology Studies
- Medical Imaging Techniques and Applications
- Renal and Vascular Pathologies
- Urological Disorders and Treatments
- Pelvic floor disorders treatments
- Medical Imaging and Pathology Studies
- Nonmelanoma Skin Cancer Studies
- Prostate Cancer Treatment and Research
- Genetics and Neurodevelopmental Disorders
- Urologic and reproductive health conditions
- Bladder and Urothelial Cancer Treatments
- Genomics and Phylogenetic Studies
- Cancer and Skin Lesions
- Organ Donation and Transplantation
- Autism Spectrum Disorder Research
- Breast Cancer Treatment Studies
- Urinary Tract Infections Management
- Viral Infections and Immunology Research
- Kidney Stones and Urolithiasis Treatments
University of Rome Tor Vergata
2016-2025
Ospedale San Carlo
2020-2024
Sapienza University of Rome
2023
Policlinico Tor Vergata
2015
University of Florence
2010
St. Eugenio Hospital
1984-2008
Athens State University
1993
Anticancer Fund
1993
Confederazione Nazionale dell'Artigianato e Della Piccola e Media Impresa
1993
To evaluate the reliability of transperineal interstitial laser ablation prostate (TPLA) in preserving antegrade ejaculation compared to transurethral resection (TURP).In this single-centre, prospective, randomized, open-label study, consecutive patients with indication for surgical treatment benign prostatic obstruction (BPO) were enrolled between January 2020 and September 2021 (NCT04781049). Patients randomized one two arms: Group A: TPLA (experimental group) B: TURP (reference standard...
Human endogenous retroviruses (HERVs) have been implicated in human physiology and pathology. A better knowledge of the retroviral transcriptional activity general population during life span would greatly help debate on its pathologic potential. The four HERV families (H, K, W, E) was assessed, by qualitative quantitative PCR, PBMCs from 261 individuals aged 1 to 80 years. Our results show that HERV-H, HERV-K, HERV-W, but not HERV-E, are transcriptionally active test already early...
Melanoma is a heterogeneous tumor in which phenotype-switching and CD133 marker have been associated with metastasis promotion chemotherapy resistance. positive (CD133+) subpopulation has also suggested as putative cancer stem cell (CSC) of melanoma tumor. Human endogenous retrovirus type K (HERV-K) described to be aberrantly activated during progression implicated the etiopathogenesis disease. Earlier, we reported that stress-induced HERV-K activation promotes malignant transformation...
Our research group and others demonstrated the implication of human endogenous retroviruses (HERVs) in SARS-CoV-2 infection their association with disease progression, suggesting HERVs as contributing factors COVID-19 immunopathology. To identify early predictive biomarkers severity, we analyzed expression inflammatory mediators SARS-CoV-2-positive -negative nasopharyngeal/oropharyngeal swabs respect to biochemical parameters clinical outcome.Residuals swab samples (20 SARS-CoV-2-negative 43...
Aim: The aim of the study was to investigate relationship between prostatic apical shape and continence recovery after robot-assisted radical prostatectomy (RARP) in a large multicentric cohort. Materials Methods: Data patients who underwent transperitoneal RARP at 10 referral robotic centers January 2017 December 2022 were retrospectively analyzed. Patients stratified into four groups based on multiparametric magnetic resonance imaging (mpMRI) apex shape. Pre-, intra-, postoperative...
Endogenous retroviruses (ERVs) are genetic elements derived from a process of germline infection by exogenous retroviruses. Some ERVs have been co-opted for physiological functions, and their activation has associated with complex diseases, including Autism Spectrum Disorder (ASD). We already demonstrated an abnormal expression in the BTBR T + tf/J (BTBR) mouse model ASD during intrauterine life till adulthood. Thus, starting assumptions that may contribute to derailment neurodevelopment...
The Autism Spectrum Disorder (ASD) is a heterogeneous group of neurodevelopmental disorders, clinically diagnosed since the lack reliable biomarkers. aetiology probably attributable to combination genetic vulnerability and environmental factors, recently, maternal immune activation has been linked derailed neurodevelopment, resulting in ASD offspring. Human endogenous retroviruses (HERVs) are relics ancestral infections, integrated human DNA. Given HERV persistence genome, some HERVs have...
Basal cell carcinoma (BCC) and squamous (SCC) are among the most common cancers in humans. Various therapies currently being used to treat these tumours including surgery, topical treatments radiotherapy. We describe a new treatment for BCC SCC. This consists of superficial radiotherapy, using synthetic resin containing radioactive beta-emitting isotope. The is applied lesion perform selective beta-irradiation brachytherapy treatment.In total, 53 patients with histologically confirmed...
Abstract Retroelements, such as Human Endogenous Retroviruses (HERVs), have been implicated in many complex diseases, including neurological and neuropsychiatric disorders. Previously, we demonstrated a distinctive expression profile of specific HERV families peripheral blood mononuclear cells from Autistic Spectrum Disorders (ASD) patients, suggesting their involvement ASD. Here used two distinct ASD mouse models: inbred BTBR T+tf/J mice CD-1 outbred prenatally exposed to valproic acid....
To evaluate the oncological and functional outcomes of transperineal laser ablation (TPLA) as focal therapy for localized prostate cancer (PCa) after a 12-month follow-up. Patients with low- intermediate-risk PCa were prospectively treated TPLA between July 2021 December 2022. The inclusion criteria following: clinical stage < T2b; PSA 20 ng/mL; International Society Urological Pathology (ISUP) grade ≤ 2; MRI-fusion biopsy-confirmed lesion classified PI-RADS v2.1 ≥ 3. Intra-, peri-,...
Malignant mesothelioma (MM) is a primary tumor arising from mesothelial cells. The survival of MM patients following traditional chemotherapy poor, thus innovative treatments for are needed. (-)-gossypol (AT-101) BH3 mimetic compound which possesses anti-tumoral activity by targeting multiple signaling transduction pathways. Several clinical trials employing AT-101 have been performed and some them still ongoing. Accordingly, we investigated the in vitro effects on cell proliferation, cycle...
Abnormal activation of human endogenous retroviruses (HERVs) has been associated with several diseases such as cancer, autoimmunity, and neurological disorders. In particular, in cancer HERV activity expression have specifically tumor aggressiveness patient outcomes. Cancer cell is intimately linked to the acquisition peculiar plasticity heterogeneity based on stemness features, well crosstalk between cells microenvironment. The latter a driving factor aggressive phenotypes, metastasis...
Recent randomized trials (RCTs) in the field of robotic partial nephrectomy (PN) showed no significant differences perioperative outcomes between off- and on-clamp approaches.To compare on- versus off-clamp pure laparoscopic PN (LPN).A multi-institutional analysis approach during LPN setting an RCT (CLOCK II trial; ClinicalTrials.gov NCT02287987) was performed.Off- LPN.Baseline patient tumor variables, peri- postoperative data were collected. Randomized allocation with a 1:1 ratio assigned....
Robotic technology allows the beginner surgeon to approach minimally-invasive partial nephrectomy (PN) avoiding otherwise long learning curve of pure laparoscopy. The present video-article reported surgical technique and outcomes first 11 cases performed by a young starting with experience robotic PN. Transperitoneal PN, an off-clamp approach, simple enucleation technique, single-layer medullar renorrhaphy was uneventfully in all but one, comparable available literature. With experience, we...