A5011828321- Antibiotics Pharmacokinetics and Efficacy
- Pesticide Residue Analysis and Safety
- Environmental Chemistry and Analysis
- Pharmacological Effects and Assays
- Marine Toxins and Detection Methods
- Analytical Methods in Pharmaceuticals
- Analytical chemistry methods development
- Forensic Toxicology and Drug Analysis
- Analytical Chemistry and Chromatography
- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Synthesis and Biological Evaluation
- Mass Spectrometry Techniques and Applications
- Environmental Toxicology and Ecotoxicology
- Microfluidic and Capillary Electrophoresis Applications
Agri Food and Biosciences Institute
2011-2023
Department of Agriculture and Rural Development
2002
Tetrodotoxins (TTXs) are traditionally associated with the occurrence of tropical Pufferfish Poisoning. In recent years, however, TTXs have been identified in European bivalve mollusc shellfish, resulting need to assess prevalence and risk shellfish consumers. Following previous identification from southern England, this study was designed wider around coast UK. Samples were collected between 2014 2016 subjected analysis using HILIC-MS/MS. Results showed continued presence toxins harvested...
Abstract Background Given the recent detection of tetrodotoxin (TTX) in bivalve molluscs but absence a full collaborative validation study for TTX determination large number shellfish samples, interlaboratory assessment method performance was required to better understand current capabilities accurate and reproducible quantitation using chemical immunoassay methods. Objective The aim conduct an with multiple laboratories, results assess acceptability different testing Methods Homogenous...
A method is described for the quantitative determination of quinoxaline-2-carboxylic acid (QCA), marker residue veterinary drug carbadox, in swine liver. Tissue subjected to alkaline hydrolysis followed by liquid–liquid extraction. QCA residues are cleaned up using automated solid phase extraction (SPE), before a final step. Analysis based on LC coupled positive ion electrospray MS-MS, monitoring product ions at m/z 129, 102 and 75 106 internal standard (d4-QCA). The has been validated...
The parent compound florfenicol (FF) is a broad-spectrum antibacterial licensed in the UK for use cattle, pigs and aquaculture industry. analysis of porcine tissues this study demonstrates that significant amounts solvent non-extractable FF-related residues are present incurred (kidney muscle) from treated animals. results indicate methods based on extraction alone may carry risk reporting false-negative results. strong acid hydrolysis step prior to tissue samples necessary an accurate...
An immunobiosensor assay was developed for multi-residue screening in bovine milk of the parent amphenicols, thiamphenicol and florfenicol, along with metabolite florfenicol amine. A polyclonal antibody raised a rabbit after immunisation amine-protein conjugate employed assay. Milk samples were subjected to acetonitrile extraction, reconstituted buffer diluted prior biosensor analysis. Validation data obtained from analysis fortified has shown that method detection capability less than 0.25...