A5037601222- CAR-T cell therapy research
- CRISPR and Genetic Engineering
- Hematopoietic Stem Cell Transplantation
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Response and Inflammation
- Immune cells in cancer
- Virus-based gene therapy research
- Barrier Structure and Function Studies
- Neurogenesis and neuroplasticity mechanisms
- Neonatal and fetal brain pathology
- Viral Infectious Diseases and Gene Expression in Insects
- Acute Myeloid Leukemia Research
- Single-cell and spatial transcriptomics
University of California, San Francisco
2024
University of California System
2024
Yale University
2023
University of New Haven
2023
Cornell University
2016-2022
Weill Cornell Medicine
2018
Acute myeloid leukemia (AML) is a disease with high incidence of relapse that originated and maintained from stem cells (LSCs). Hematopoietic can be distinguished LSCs by an array cell surface antigens such as CD123, thus candidate to eliminate using variety approaches, including CAR T cells. Here, we evaluate the potential allogeneic gene-edited targeting CD123 (UCART123). UCART123 are TCRαβneg generated healthy donors TALEN® gene-editing technology, decreasing likelihood graft vs host...
ABSTRACT Traumatic brain injury (TBI) is a leading cause of mortality and disability worldwide can lead to secondary sequelae such as increased seizure susceptibility. Emerging work suggests that the thalamus, relay center undergoes damage after cortical TBI, involved with heightened risks TBI. TBI also induces recruitment peripheral immune cells, including T site(s) injury, but it unclear how these cells impact neurological post-TBI. Here, we characterize identities kinetics lymphocytic...
Fibroblasts coordinate the response to tissue injury, directing organ regeneration versus scarring. In central nervous system (CNS), fibroblasts are uncommon cells enriched at borders, and their molecular, cellular, functional interactions after brain injury poorly understood. Here we define fibroblast sterile damage across time space. Early pro-fibrotic myofibroblasts infiltrated CNS lesions were functionally spatially organized by TGF β signaling, macrophages microglia, perilesional glia...
Systemic inflammation halts lymphopoiesis and prioritizes myeloid cell production. How blood production switches from homeostasis to emergency myelopoiesis is incompletely understood. Here, we show that lymphotoxin-β receptor (LTβR) signaling in combination with TNF IL-1 bone marrow mesenchymal stem cells (MSCs) down-regulates Il7 expression shut down during systemic inflammation. LTβR MSCs also promoted CCL2 Pharmacological or genetic blocking of partially enabled reduced monocyte numbers...
Abstract Acute myeloid leukemia (AML) is a fatal disease. The promise of autologous T-cells expressing chimeric antigen receptors (CARs) in targeting B-cell malignancies has encouraged extension this approach to AML. However, clinical guidance regarding infusion and re-infusion regimens for CAR-T technology unclear any cancer including Given that studies demonstrate clear benefit minimal residual disease (MRD) assessment predicting relapse AML, we thus sought ascertain whether simultaneous...