A5100750438- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Mosquito-borne diseases and control
- Enzyme Catalysis and Immobilization
- Viral Infections and Vectors
- Cancer Risks and Factors
- Microbial Metabolic Engineering and Bioproduction
- Heme Oxygenase-1 and Carbon Monoxide
- Fungal Biology and Applications
- Breast Cancer Treatment Studies
- Epigenetics and DNA Methylation
- Vector-borne infectious diseases
- Animal Disease Management and Epidemiology
- Mesenchymal stem cell research
- Ginkgo biloba and Cashew Applications
- Pharmacogenetics and Drug Metabolism
- Lichen and fungal ecology
- Animal Virus Infections Studies
- Global Cancer Incidence and Screening
- Zoonotic diseases and public health
- Mycorrhizal Fungi and Plant Interactions
- Venous Thromboembolism Diagnosis and Management
- Insect and Pesticide Research
- Acute Lymphoblastic Leukemia research
- Food Quality and Safety Studies
Kangwon National University
2021-2024
Yeungnam University
2024
Ulsan College
2018-2020
Asan Medical Center
2018-2020
University of Ulsan
2018-2020
Pohang University of Science and Technology
2010-2017
Government of the Republic of Korea
2014
Korea Institute of Toxicology
2014
Dongguk University
2013
Celltrion (South Korea)
2013
Hydrogen sulfide has emerged as an exciting endogenous gasotransmitter in addition to nitric oxide and carbon dioxide. Noninvasive detection methods for hydrogen thus become indispensable tools studying its diverse roles biological systems. Accordingly, fluorescent probes have received great attention recent years. A practically useful probe bioimaging of should be selective, sensitive, fast-responsive, biocompatible, observable the optical window, capable deep-tissue imaging. These sensing...
The selective detection of cysteine and homocysteine over glutathione other amino acids was demonstrated with an 8-MeS-BODIPY probe by mimicking the native chemical ligation approach, which allowed ratiometric fluorescence sensing biothiols at physiologically relevant concentrations in different organs a zebrafish.
Metastasis and invasion are among the main causes of death in patients with malignant tumors. The aim this study was to determine anti-invasive activity frondoside A against human breast cancer cells. We investigated inhibitory effect on cell clonogenicity, migration TPA-stimulated cells at non-cytotoxic concentrations. Frondoside significantly attenuated TPA-induced colony formation, MBA-MB-231 Induction MMP-9 is especially important for metastasis many tumor types. Additionally, we found...
The Korean water deer (WD), a predominant wildlife species in South Korea, is listed as vulnerable by the IUCN Red List. Despite belonging to same family, Cervidae, WD show significantly fewer adult ixodid tick infestations compared roe (RD). Ticks, which cannot fly, engage questing behavior natural environments latch onto hosts. They detect signals like body temperature and host skin chemicals navigate through hair coat preferred epidermis. In light of this, we performed an extensive...
Modeling the relationship between age and mortality for breast cancer patients may have important prognostic therapeutic implications.
This study aimed to evaluate the usefulness of four microRNAs (miRNAs) in an acute pancreatic injury dog model. Acute pancreatitis was induced by infusion cerulein for 2 h (7.5 μg/kg/h). The levels well-known miRNAs, microRNA-216a (miR-216a) and microRNA-375 (miR-375), new candidates microRNA-551b (miR-551b), microRNA-7 (miR-7), were measured at 0, 0.5, 1, 2, 6, 12, 24 with serum amylase lipase, histopathological examination performed. Among miR-216a miR-375, enzymes significantly increased...
Drug-induced phospholipidosis (PL) is a storage disorder caused by the formation of phospholipid-drug complexes in lysosomes. Because diversity PL between species, human cell-based assays have been used to predict drug-induced humans. We established three-dimensional (3D) liver organoids as described previously and investigated their characteristics through multiple analyses. was initiated these monolayer HepG2 cultures, cellular changes were systemically examined. Organoids that underwent...
Mosquitoes secrete saliva that contains biological substances, including anticoagulants counteract a host's hemostatic response and prevent blood clotting during feeding. This study aimed to detect heparin, an anticoagulant in Aedes togoi using immunohistochemical detection method, the salivary canal, gland, midgut of male female mosquitoes. Comparisons showed mosquitoes contained higher concentrations heparin than On average, level was blood-fed non-blood-fed Heparin were gland. indicates...
Abstract Mosquitoes act as a vector for the transmission of disease. The World Health Organization has recommended strict control mosquito larvae because their “few, fixed, and findable” features. respiratory system pupae in water weak point. As aquatic organisms, inhale atmosphere oxygen. However, have non-feeding stage, unlike larvae. Therefore, detailed study on tracheal is helpful understanding survival strategy. In this study, three-dimensional (3D) structures systems Anopheles sinensis...
Periodontitis, a chronic inflammatory periodontal disease that develops from gingivitis, is caused by pathogenic bacteria such as Porphyromonas gingivalis. Recent studies have focused on the antioxidant, anti–human immunodeficiency virus, anticarcinogenic, and anti-inflammatory properties of gomisins. However, activities gomisin plants through heme oxygenase-1 (HO-1) signals remain poorly defined. We found gomisins' activity occurs via induction HO-1 expression. Gomisins G J inhibit...
Purpose: Pathologic tooth migration (PTM) is a displacement which derived from imbalance of retention force and dominantly found out in maxillary anterior area.PTM area was tried to corrected with periodontal treatment clear aligner this study the result evaluated clinically radiographically.Methods: For patient chronic disease accompanied by pathologic migration, applied move teeth after series case-related therapy.Clinically, probing depth, gingival recession, clinical attachment level...
Newborn piglets are susceptible to a highly contagious enteritis caused by the porcine epidemic diarrhea virus (PEDV), associated with high levels of mortality worldwide. There is pressing need for rapid, safe, and cost-effective vaccine safeguard pigs from getting infected PEDV. PEDV belongs coronavirus family characterized mutability. The primary goal provide immunity newborn through vaccination sows. Plant-based vaccines becoming more popular because they have low manufacturing costs,...
M1 RNA, the gene product of rnpB, is catalytic subunit RNase P in Escherichia coli. RNA transcribed from a proximal promoter as pM1 precursor and then processed at its 3' end by E. In addition to large rnpB-containing transcripts are produced unknown upstream promoters. However, it not known yet how these contribute biosynthesis. To examine their biological relevance biosynthesis, we constructed model transcript, upRNA, analyzed cellular metabolism. We found that upRNA was primarily degraded...
Background ARID2 belongs to the Switch/sucrose non-fermenting complex, in which genetic defects have been found patients with dysmorphism, short stature and intellectual disability (ID). As phenotypes of mutations partially overlap those RASopathy, this study evaluated biochemical association between RAS-MAPK pathway. Methods The 22 either an heterozygous mutation or haploinsufficiency were reviewed. Comprehensive molecular analyses performed using somatic induced pluripotent stem cells...
Species of Phellinus were known to harmful fungi causing white pocket rot and severe plant disease such as canker or heartrot in living trees the West, but some species have been used traditional medicines Orient for a long time. In this study partial D1-D2 nucleotide sequences 28S ribosomal DNA from 13 strains determined compared with 21 obtained GenBank database. According neighbor-joining (NJ) method comparing sequence data phylogenetic tree was constructed. The displayed presence four...
In connection with the studies for developing new enzymes that could be useful in organic synthesis, practical preparation of racemic and enantiopure forms <TEX>${\gamma}$</TEX>-hydroxy-<TEX>${\alpha}$</TEX>-keto acids has been successfully achieved. For form acids, indium-mediated allylation aldehydes 2-(bromomethyl)acrylic acid employed as a key step. Oxidative cleavage thus formed 2-methylenebutyrolactones provided desired <TEX>${\alpha}$</TEX>-ketobutyrolactones. Enzymatic resolution...