A5019017635- Bariatric Surgery and Outcomes
- Diet and metabolism studies
- Gastric Cancer Management and Outcomes
- Nutritional Studies and Diet
- Nutrition and Health in Aging
- Folate and B Vitamins Research
- Clinical Nutrition and Gastroenterology
- Diabetes Treatment and Management
- Gastroesophageal reflux and treatments
- Hormonal Regulation and Hypertension
- Esophageal and GI Pathology
- Cardiac and Coronary Surgery Techniques
- Burn Injury Management and Outcomes
- Liver Disease Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Fatty Acid Research and Health
- Enhanced Recovery After Surgery
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Intestinal Malrotation and Obstruction Disorders
- Cardiac Structural Anomalies and Repair
- Esophageal Cancer Research and Treatment
- Biochemical Analysis and Sensing Techniques
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Bone and Dental Protein Studies
- Diet, Metabolism, and Disease
Instituto Nacional de Cardiologia
2024
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2015-2023
Centro Universitário das Faculdades Metropolitanas Unidas
2021-2023
Universidade de São Paulo
2016-2022
Fundação de Apoio à Universidade Federal de São Paulo
2015
Universidade Federal de São Paulo
2011-2014
Directorate-General for Interpretation
2014
Hôpital de la Conception
2014
Roux-en-Y Gastric bypass (RYGB) promotes improvement in type 2 diabetes (T2D) shortly after surgery, with metabolic mechanisms yet to be elucidated. This study aimed investigate the relationship between food intake, tryptophan metabolism, and gut microbiota on glycemic control of obese T2D women RYGB surgery. Twenty who underwent were evaluated before three months Food intake data obtained by a seven-day record frequency questionnaire. Tryptophan metabolites determined untargeted metabolomic...
Objective To describe the protocol of SURgically induced Metabolic effects on Human GastroIntestinal Tract (SURMetaGIT) study, a clinical pan-omics study exploring gastrointestinal tract as central organ driving remission type 2 diabetes mellitus (T2DM) after Roux-en-Y gastric bypass (RYGB). The main points considered in study's design and challenges faced its application are detailed. Methods This observational, longitudinal, prospective involved collection biopsy specimens, faeces, urine,...
OBJECTIVES: Vitamin B12 (B12) deficiency after Roux-en-Y gastric bypass (RYGB) is highly prevalent and may contribute to postoperative complications. Decreased production of intrinsic factor owing fundus removal thought have a major role, but other components metabolism also be affected. We evaluated changes in the expression levels multiple pathway-encoding genes gastrointestinal (GI) tissues evaluate potential roles contributing post-RYGB deficiency. METHODS: During double-balloon...
More than half of patients who undergo Roux-en-Y gastric bypass (RYGB) can experience type 2 diabetes (T2D) remission, but the systemic and gastrointestinal (GI) metabolic mechanisms this improvement are still elusive.Paired samples collected before 3 months after RYGB from 28 women with obesity T2D were analyzed by metabolomics gas chromatography coupled to mass spectrometry. Samples include plasma (n = 56) biopsies pouch 18), remnant 10), duodenum 16), jejunum ileum double-balloon...
Abstract We evaluated whether the excluded stomach (ES) after Roux-en-Y gastric bypass (RYGB) can represent a premalignant environment. Twenty obese women were prospectively submitted to double-balloon enteroscopy (DBE) with juice and biopsy collection, before 3 months RYGB. then morphological molecular changes by combining endoscopic histopathological analyses an integrated untargeted metabolomics transcriptomics multiplatform. Preoperatively, 16 already presented alterations increased pH...
PURPOSE: To evaluate microscopic behavior and viability of dental pulp stem cells under glucose glutamine deprivation. METHODS: Human tooth tissues were minced in isolated pieces cultured until the desired cellular proliferation for experimental phases. Cells variations both serum presence absence, then those evaluated according to number by MTT assay. The confocal microscopy analyzed cytoskeleton, nucleus, mitochondria integrity. RESULTS: A low concentration favored behavior; culture medium...
Abstract Bile acids (BAs) are key mediators of the glycemic control after bariatric surgeries. Cholecystectomy modifies kinetics BAs, and whether this procedure influences BAs pool its metabolic response to surgeries is not known. We used targeted untargeted metabolomics assess cholecystectomy influenced plasma fecal fluctuations systemic metabolomic profile Roux-en-Y gastric bypass (RYGB). Women with obesity type 2 diabetes were included. Sample collections clinical evaluations performed...
Objectives: To review the nutritional evaluation in burned patient, considering literature descriptions of and energy requirements these patients. Introduction: Thermal injury is traumatic event with highest metabolic response critically ill Various mathematical formulas have been developed to estimate patient. Indirect Calorimetry only method considered gold standard for measuring caloric expenditure. Methods: A survey data was collected based on official bases, LILACS, EMBASE PubMed....
Roux-en-Y gastric bypass (RYGB) is one of the most performed bariatric surgical techniques. However, RYGB commonly results, as side effects, in nutritional deficiencies. This study aimed to examine changes expression vitamin A pathway encoding genes gastrointestinal tract (GI) and evaluate potential mechanisms associated with hypovitaminosis after RYGB. Intestinal biopsies were obtained through double-balloon endoscopy 20 women obesity (age 46.9±6.2 years; body mass index [BMI] 46.5±5.3 kg/m
The objective of this study was to examine potential mechanisms leading the often‐observed Vitamin B 12 deficiency following Roux‐en‐Y gastric bypass (RYGB). absorption begins with release from food in upper GI tract followed by transcobalamin I binding; duodenal enzyme degradation is then intrinsic factor (IF) capture; IF next degraded within ileal enterocyte, releasing that enters plasma. Although levels are reduced RYGB due removal fundus, other causes modified transport may be involved....